Finite element analysis of polymer microneedle for transdermal drug delivery

Radhika, C.; Gnanavel, B. K.

doi:10.1016/j.matpr.2020.05.549

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…These experiments have shown that polymer MNs can be translated clinically. However, we know that to date, no clinical trials on the continuous release of MNs are published [ 361 , 362 , 363 , 364 , 365 , 366 ]. Immune modeling and the treatment of diseases in mice models have been effectively developed and implemented by MNs with continued release properties of drugs or vaccines.…”

Section: Regulatory Issues With Polymeric Microneedlesmentioning

confidence: 99%

“…The combined efforts of engineering, pharmaceuticals, and immunology researchers can promote the future success of this technology and clinical translation [ 365 ]. A micro-based lithographic approach to the manufacturing of tapered-cone MNs was developed to create MNs using biodegradable sharp tips, micro-e-machining, and etching [ 26 ].…”

Section: Current Trends and Future Perspectivementioning

confidence: 99%

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Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Section: Regulatory Issues With Polymeric Microneedlesmentioning

confidence: 99%

Section: Current Trends and Future Perspectivementioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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“…(2) C. Linear Buckling analysis The linear buckling analysis is performed using the linear perturbation method using ABAQUS 6.14 software. The microneedle model is meshed using the C3D10 mesh element [27]. A unit load (1N) is applied on the top of the microneedle and the base is arrested.…”

Section: B Theoretical Studymentioning

confidence: 99%

Post buckling analysis of silicon microneedle

Kumar

Karnal

2021

Preprint

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The microneedle is used to deliver the drug inside the skin structure. During the insertion procedure, the microneedle travel up to the dermis layer through the stratum corneum and epidermis layer. The microneedle have a tendency to critically buckle when the applied load achieves the maximum buckling load. To avoid structural failure of the microneedle, the critical load is identified and safely applied. In this paper, the critical buckling load is identified using the linear and non-linear buckling analysis. The critical load using linear buckling analysis is found to be 263.7µN. The non-linear or post -buckling analysis is performed for the load of 263.7µN and the critical load is found to be 149µN. Thus for silicon microneedle, the critical load is identified as 149µN. Henceforth for silicon microneedle, the applied load should always be smaller than the critical buckling load for safe insertion.

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“…The finite element analysis is accomplished to evaluate and inspect the capacity of solid porous silicon microneedles array while the penetration of skin across the human [9] skin. In this analysis, the impact of different loads on a solid microneedle array was inspected to forecast the mechanical characteristics of an array of microneedles [10] .…”

Section: Introductionmentioning

confidence: 99%

Structural analysis and simulation of solid microneedle array for vaccine delivery applications

Mannayee

2022

Materials Today: Proceedings

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Finite element analysis of polymer microneedle for transdermal drug delivery

Cited by 8 publications

References 25 publications

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Post buckling analysis of silicon microneedle

Structural analysis and simulation of solid microneedle array for vaccine delivery applications

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