Fine Needle Aspiration Cytology of Malacoplakia of the Thyroid

Jeffrey, P. B.; Chandrasoma, Parakrama; Greaves, Timothy S.

doi:10.1159/000334011

Cited by 16 publications

(24 citation statements)

References 5 publications

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“…FNAB is a method used worldwide to diagnose thyroid nodules but it has limitations, such as false-positive ( 1,2 ), FN ( 1-3 ), and inadequate results ( 1,2,4,5 ). The causes of false-positive and FN results are the nature of the lesions, intrinsic limitations of the procedure, and the manner, skill, and experience of the operator ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…The W hen diagnosing focal thyroid nodules, fi ne-needle aspiration biopsy (FNAB) is an essential tool to help decide whether a nodule requires surgery. However, FNAB has inevitable limitations in helping diagnose a thyroid nodule, such as falsepositive ( 1,2 ), false-negative ( 1-3 ), and inadequate ( 1,2,4,5 ) results. Although the Papanicolaou Society of Cytopathology Task Force on Standards of Practice recommends that the false-negative (FN) rate not exceed 2% and the falsepositive rate not exceed 3% for FNAB cytologic evaluation of the thyroid ( 6 ), the reported FN rate of FNAB ranges from 2.3% to 6.2% ( 7-9 ) and the falsepositive rate of FNAB ranges from 0.2% to 11.6% (7)(8)(9)(10)(11).…”

Section: Study Populationmentioning

confidence: 99%

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Value of US Correlation of a Thyroid Nodule with Initially Benign Cytologic Results

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Value of US Correlation of a Thyroid Nodule with Initially Benign Cytologic Results

et al. 2010

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“…2,3 Thus, the commonly used needles would have internal diameters better than 20-50 times that of a follicular cell nucleus. Since three dimensional follicles average around 200 lm, but vary considerably, these commonly used needle sizes often allow passage of intact individual follicles or even small stromal-epithelial fragments (''mini-cores'') on many FNA smears.…”

Section: Aspiration Devices Needles and Methods Needlesmentioning

confidence: 99%

Techniques for thyroid FNA: A synopsis of the National Cancer Institute Thyroid Fine‐Needle Aspiration State of the Science Conference

Pitman

Abele

Ali

et al. 2008

Diagnostic Cytopathology

202

152

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The National Cancer Institute (NCI) sponsored the NCI Thyroid fine-needle aspiration (FNA) State of the Science Conference on October 22-23, 2007 in Bethesda, MD. The 2-day meeting was accompanied by a permanent informational website and several on-line discussion periods between May 1 and December 15, 2007 (http://thyroidfna.cancer.gov). This document summarizes matters addressing manual and ultrasound guided FNA technique and related issues. Specific topics covered include details regarding aspiration needles, devices, and methods, including the use of core needle biopsy; the pros and cons of anesthesia; the influence of thyroid lesion location, size, and characteristics on technique; the role of ultrasound in the FNA of a palpable thyroid nodule; the advantages and disadvantages of various specialists performing a biopsy; the optimal number of passes and tissue preparation methods; sample adequacy criteria for solid and cystic nodules, and management of adverse reactions from the procedure. (http://thyroidfna.cancer.gov/pages/info/agenda/)

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“…Moreover, a substantial proportion of samples represent "follicular proliferation", neither clearly benign nor malignant and fall into the category of suspicious results. As already noted, about 70% of FNA specimens are classified as benign; in addition, 5% are malignant, 10% are suspicious, and 10% to 20% are non-diagnostic [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Fine Needle Aspiration and Fine Needle Non-Aspiration Biopsy on Suspected Thyroid Nodules

et al. 2009

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Ultrasonography-guided fine needle aspiration (FNA) and fine needle non-aspiration (FNNA) biopsy were performed consecutively on 104 patients (mean age 50 +/- 15 years) affected by multinodular and uninodular goiter. Both techniques were executed on the same patients in the same clinical session beginning with the first (FNA) on half of the patients (randomly selected) and vice versa. The cytological findings on cell samples were divided into four groups: colloidal (benign), follicular (suspicious), malignant, and inadequate. The overall cytologic findings obtained with the two techniques were as follows (FNA % vs FNNA %): inadequate, 16.3% vs 5.8%; colloidal, 69.2% vs 76.9%; follicular, 9.6% vs 10.5%; and malignant, 4.8% vs 6.7%. A statistically significant difference between FNA and FNNA cytology was found only on the number of inadequate results (p = 0.015). Interestingly, the frequency of inadequate specimens for FNNA showed a significantly different distribution depending on the sequence (first or second) in which the technique was executed. In conclusion, FNA and FNNA are useful and cost-effective techniques for the pre-operative assessment of patients with thyroid nodules. However, due probably to its minimally invasive procedure, FNNA produces specimens of better quality and reduces inadequate results. For these reasons FNNA should be preferable to FNA for the cytological evaluation of thyroid nodules.

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Fine Needle Aspiration Cytology of Malacoplakia of the Thyroid

Cited by 16 publications

References 5 publications

Value of US Correlation of a Thyroid Nodule with Initially Benign Cytologic Results

Value of US Correlation of a Thyroid Nodule with Initially Benign Cytologic Results

Techniques for thyroid FNA: A synopsis of the National Cancer Institute Thyroid Fine‐Needle Aspiration State of the Science Conference

A Comparative Study of Fine Needle Aspiration and Fine Needle Non-Aspiration Biopsy on Suspected Thyroid Nodules

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