Fine‐needle aspiration cytology of Rosai‐Dorfman disease

Fine needle aspiration cytology of an enlarged inguinal lymph node

“…14 Large histiocytes showed small vacuoles on MGG stain, a feature believed due to the presence of lipids. 4,10 CD1a S-100 protein Immunocytochemically, the large histiocytes revealed pattern of reactivity reflecting previous immunocytochemical and immunohistochemical characterizations of the large histiocytes in SHML, 7,11,12,[14][15][16] as shown in Table 1. This immunophenotype seems to indicate that the effector cell in SHML is a functionally activated macrophage and is distinct from Langerhans cells, follicular dendritic cells and interdigitating dendritic cells.…”

“…4 The lymphadenopathy is due to an expansion of sinuses with benign histiocytes and to infiltration of plasma cells into the medullary cords. 7,11,12 This paper describes the cytomorphological and immunocytochemical features in FNAC material obtained from an inguinal lymph node of SHML. 5 Capsular fibrosis of involved nodes is present.…”

“…3 Although the cytomorphological features of SHML have been well documented in lymph node, 7-11 the literature contains only a few isolated cases describing the immunocytochemical features derived from fine needle aspiration cytology (FNAC). 7,11,12 This paper describes the cytomorphological and immunocytochemical features in FNAC material obtained from an inguinal lymph node of SHML.…”

Emperipolesis in the cerebrospinal fluid from a patient with Rosai‐Dorfman disease

“…Emperipolesis is considered the most remarkable diagnostic feature of Rosai-Dorfman disease not only in biopsies but also in fine-needle aspiration specimens, but is not pathognomonic. 2 Rosai-Dorfman disease has been reported at several extranodal sites. [3][4][5][6][7][8] Central nervous system (CNS) involvement is unusual and occurs in less than 5% of cases.…”