Fine needle aspiration cytology of the thyroid osteosarcoma

Syrjänen, Karí

doi:10.1007/bf00408105

Cited by 6 publications

(7 citation statements)

References 4 publications

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“…The extraosseous form of osteosarcoma occurs very rarely (approx. 5%), especially in the thyroid, where, so far, it has been diagnosed in 28 cases [5], and in only two cases with fine-needle biopsy [6, 7]. This tumour is characterised by fast growth and requires quick surgical intervention due to pressure-related symptoms of dyspnoea.…”

Section: Discussionmentioning

confidence: 99%

“…The nuclei of these cells are usually elongated or oval-shaped, with coarse-grained chromatin and quite distinct chromocentres, often eccentric as in plasmocytes. In the background, there are usually binuclear and polynuclear cells with considerable polymorphism, some of which resemble osteoclasts [6, 7]. Beside cells, there may be masses partially composed of fibrillar structures, adjacent to tumour cells.…”

Section: Discussionmentioning

confidence: 99%

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Primary osteosarcoma of the thyroid gland – a

Zembala‐Nożyńska

Lange²

2013

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A rare localization of primary osteosarcoma is presented. A woman aged 76 years was operated on for rapid growth of thyroid right lobe tumour. Histopathology showed anaplastic cancer with numerous foci of osseous metaplasia, negative with thyroglobulin, calcitonin, synaptophysin and chromogranin. A high proliferative activity of the tumour was observed (MIB-1 reaction) in the form of a positive reaction in approx. 40% of the tumour cell nuclei. The tumour stage was evaluated as pT4aNxMx according to the TNM scale. The reconsultation revealed negative staining with cytokeratin, and positive with vimentin, thereby confirming the mesenchymal origin of the tumour, with the final diagnosis being primary thyroid osteosarcoma. Taking into consideration the histopathological diagnosis, the extremely low radiation sensitivity of the tumour, the patient's age, the radical surgical treatment and persisting respiratory failure, radiotherapy was rejected in favour of further follow-up. The patient remains under oncological and endocrinological care.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary osteosarcoma of the thyroid gland – a

Zembala‐Nożyńska

Lange²

2013

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“…10,[19][20][21][22][23][24] The cytologic features of primary osteosarcoma of the thyroid were described in one of the reported cases. 25 The smears of osteosarcoma are usually cellular and contain dense aggregates, loosely cohesive clusters, or dissociated single neoplastic cells in a bloody background. The individual tumor cells may be spindle-shaped, round, or polygonal, with abundant bluegray cytoplasm in Diff-Quik-stained smears.…”

Section: Discussionmentioning

confidence: 99%

Fine‐needle aspiration biopsy of primary osteosarcoma of the thyroid: Report of a case and review of the literature

Tong

Hamele‐Bena

Liu

et al. 2008

Diagnostic Cytopathology

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Primary osteosarcoma of the thyroid is an extremely rare tumor, with only 27 well-documented cases reported in the literature, including only one in the cytology literature. We describe here an additional case with fine-needle aspiration biopsy findings. A 60-year-old woman presented with a 1-month history of progressive midline neck swelling. CT and ultrasound demonstrated a large thyroid mass with tracheal compression. Fine-needle aspiration biopsies were performed and showed pleomorphic spindle and epithelioid neoplastic cells, multinucleated giant cells, and scant metachromatic extracellular matrix material. Cell block sections contained minute tissue fragments with neoplastic spindle cells. Immunohistochemical stains showed the tumor cells to be positive for vimentin and negative for cytokeratins, TTF-1, calcitonin, synatophysin, chromogranin, and S-100 protein, suggesting a sarcoma; however, the differential diagnosis also included anaplastic thyroid carcinoma and medullary thyroid carcinoma. Tissue biopsy revealed a high-grade spindle cell neoplasm with osteoid production, consistent with osteosarcoma of the thyroid. The patient developed a large pulmonary embolus and superior vena cava syndrome and no further surgical intervention was performed. She died 5 weeks after the initial diagnosis. Upon retrospective review, the cytologic features resemble osteosarcoma in other areas. Although cytologic features on fine-needle aspiration biopsy may suggest a diagnosis of this rare entity, definitive diagnosis should be deferred to histologic examination.

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“…Osteosarcomas usually have diffuse moderate to strong intra-cytoplasmic staining for CD99. Osteocalcin and osteonectin may be used to highlight osteoid (2,3,(7)(8)(9)10) .…”

Section: Figure 2 -Primary Thyroid Osteosarcoma: a High Grade Malignamentioning

confidence: 99%

Primary osteosarcoma of the thyroid gland: report of a rare neoplasm

Cambruzzi

Scholl

Molinari

et al. 2013

J. Bras. Patol. Med. Lab.

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Primary mesenchymal tumors of the thyroid gland are extremely rare. The authors report a case of primary thyroid osteosarcoma in a male patient presenting a tumoral mass in the neck. CT scan demonstrated a large tumor in the right thyroid lobe with areas of calcification. The surgical specimen consisted of a hard brown-gray tumor, measuring 13 × 11 × 7.5 cm. Microscopy revealed a high-grade malignant neoplasm composed of polygonal cells of intermediate size, chondroid pattern in some areas and osteoid formation. The process was immunonegative for AE1/AE3, glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), p53 and thyroid transcription factor-1 (TTF-1), and immunopositive for CD99 and S100. Thus the diagnosis of primary osteosarcoma of the thyroid gland was established.

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Fine needle aspiration cytology of the thyroid osteosarcoma

Abstract: The fine needle aspiration cytology of a histologically verified primary osteosarcoma of the thyroid gland is reported for the first time in literature. The histogenesis and the differential diagnostic aspects of this extremely rare tumor are briefly discussed.

Cited by 6 publications

References 4 publications

Primary osteosarcoma of the thyroid gland – a

Primary osteosarcoma of the thyroid gland – a

Fine‐needle aspiration biopsy of primary osteosarcoma of the thyroid: Report of a case and review of the literature

Primary osteosarcoma of the thyroid gland: report of a rare neoplasm

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