Fine needle aspiration cytology of lymph nodes - An institutional study of 1448 cases over a five year period

Paul, PC; Goswami, BK; Chakrabarti, Subrata; Giri, Amita; Pramanik, Raghunath

doi:10.4103/0970-9371.238325

Cited by 13 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its broad applicability in the assessment of lymphadenopathy is facilitated by its minimal invasiveness, rapidity, costeffectiveness, and the ability to provide material for multiple ancillary techniques [4]. Nevertheless, the traditional, currently used method of reporting lymph node smears lacks a consistent diagnostic categorization, a shared language of reporting among cytopathologists, and unambiguous communication to physicians regarding the risk of malignancy and subsequent therapy [3,6,14].…”

Section: Discussionmentioning

confidence: 99%

Sydney Reporting System for Lymph Node Fine Needle Aspiration and Malignancy Risk Stratification, Is it of Clinical Value?

Alqaidy

2024

Preprint

View full text Add to dashboard Cite

Lymphadenopathy is a common manifestation of both reactive and malignant diseases, and fine needle aspiration (FNA) is an effective and inexpensive screening method. It can prevent unnecessary invasive surgery and excisional biopsy, especially in benign cases. Unfortunately, the lack of universally accepted terminology for reporting results has hindered its widespread support. The Sydney system proposal for lymph node cytopathology categorization and reporting introduced five diagnostic categories to address the lack of universally accepted terminology for reporting results in lymphadenopathy. Our study analyzed 188 lymph node FNC samples from King Abdulaziz University Hospital, Saudi Arabia, examining clinical follow-up data, pathology records, patient information, and final diagnosis from January 2019 to December 2022. Most specimens were from axillary LNs, with 99.5% tissue correlation. The Sydney System Category classification identified 56.9% of cases as malignant, while 26.1% were benign. The final surgical specimen diagnosis revealed a higher percentage of malignant diagnoses, with the highest ROM in malignant/Category V. In conclusion, our study demonstrates that LN-FNAC offers high diagnostic accuracy for LN aspirates, with the Sydney approach potentially aiding risk stratification and achieving consistency in cytologic diagnosis, but further multi-centric research is needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Sydney Reporting System for Lymph Node Fine Needle Aspiration and Malignancy Risk Stratification, Is it of Clinical Value?

Alqaidy

2024

Preprint

View full text Add to dashboard Cite

show abstract

Limitations in Cytodiagnosis- An Institutional Study

Uma¹,

Rajani²

2018

jemds

View full text Add to dashboard Cite

BACKGROUND Fine needle aspiration cytology has replaced open biopsy in majority of the palpable lesions. Differentiation between benign and malignant lesions is possible with this procedure with low cost, but has certain limitations. In the present study, the limitations of cytodiagnosis in various palpable lesions in the body is analysed.The aim of the study was to know the prevalence of various lesions which could be diagnosed on cytology, its limitations and need for histopathological examination. MATERIALS AND METHODSA prospective observational study was conducted in the Department of Pathology at tertiary care centre in rural area. 1200 cases attending for fine needle aspiration for a period of 2 years from January 2014 to December 2015 was taken up for the study. After obtaining informed consent from the patients, fine needle aspiration was performed using a 22 -24 gauge needle with 10 mL syringe and long lumbar puncture needle for guided aspirations. Smears were fixed in 95% isopropyl alcohol and stained with Haematoxylin and Eosin. Air dried smears were stained with May-Grunwald stain and special stains were done wherever necessary. The tissue was subjected for histopathological examination wherever indicated and results tabulated. Overall diagnostic accuracy, sensitivity and specificity of cytology as a diagnostic procedure was calculated. RESULTSThe overall accuracy of diagnosing granulomatous lymphadenitis and lymphoproliferative disorders on cytology was 65.71%. The overall accuracy of diagnosing fibrocystic disease of breast proliferative type was 80% and ductal carcinoma of breast was 100% on cytology. The overall accuracy of diagnosing follicular adenoma of thyroid was 36.20% and malignancy was 100% on cytology. The overall accuracy of diagnosing both benign and malignant lesions of salivary gland was 100% on cytology. The overall accuracy of diagnosing soft tissue tumours was 88.67% on cytology. In lesions of bone, skin and ultrasonographic-guided lesions of abdomen, the overall accuracy was 100%. On Pap smears, the overall accuracy was 84.48%. CONCLUSIONIn cases of granulomatous lymphadenitis without significant necrosis and negative AFB, fibrocystic disease of breast, follicular adenoma of thyroid, vascular tumours, soft tissue tumours with nuclear atypia and cases of atypical squamous cell of undetermined significance and high-grade intraepithelial lesions on Pap smears need histopathological examination for accurate diagnosis.

show abstract