Fine needle aspiration cytology in a palpable breast lesion

Abstract

Background: Breast cancer is the common malignant lesion in women. Fine needle aspiration cytology has high sensitivity and specificity and is a simple, rapid and safe method to diagnose breast lesions. The aim of the study was to categorize breast lesions and correlate the Fine needle aspiration cytology diagnosis with histopatholoical findings. Materials and Methods:This was a retrospective study done in department of Pathology of Institute of medicine, Trivuwan university teaching hospital, from January 2007 to December 2010. There were 1403 FNAC cases and 469 histopathology cases. Fine needle aspiration correlation with histopathology was done in 249 cases. All the cases were categorized according to risk for cancers: Unsatisfactory sample, Inflammatory breast disease Benign proliferative breast disease without atypia, Benign proliferative breast disease with atypia, Suspicious for malignancy and Malignant lesions. Results:Benign breast lesions were common in the age group of 21-30 years and malignant breast lesion common in the age of 41-50 years of age. In our study fibroadenoma was most common benign lesion and ductal carcinoma was the most common malignant lesion. The sensitivity and specificity of FNAC for malignancy were found to be 98.2% and 98.5% respectively. Conclusion:Fine needle aspiration cytology is highly sensitive and specific technique for diagnosis of most of the malignant and benign breast lesions.

Cytomorphological Study of Spectrum of Breast Lesions and Determination of Efficacy of Fnac in the Diagnosis of Various Breast Lesions

“…[2,4,5,6,7,8,9] Proof of malignancy is the usual aim of such a procedure although it can be used for diagnosis of benign lesions as well as some inflammatory conditions. [5,7,8] The present study comprised of 529 aspirations performed on 512 patients. In 17 cases (3.2%), a second pass was needed, as the material was inadequate in the first instance.…”

Clinico-pathologic profile of women with palpable breast lumps in Chitwan Medical College, Nepal

“…Two studies from Nepal have found fibrocystic change as the most common breast lesion. 13,14 While other studies from Nepal have found fibroadenoma as the most common breast lesion. 15,16 Studies from Lahore, Aurangabad and Mumbai have found fibroadenoma as the most common breast disease.…”

“…In all studies from Nepal, fibroadenoma was found as the most common benign neoplasm. [13][14][15][16] And as already mentioned, the neoplasm has been found to be even more common than fibrocystic change in some of those studies. 15,16 In the developed countries, carcinoma of breast is the most common non-skin malignancy in women.…”

“…The figure varies from 6.6 % to 18.8 % in other national studies. [13][14][15][16] The value varies from 12% to 20% in studies from India, Pakistan and Bangladesh. [17][18][19][20] Average age at diagnosis of breast cancer was found to be 49.2 ± 12.0 years in the present study.…”

Cytopathology of Canine Mammary Gland Affections

“…It has been postulated that inflammatory and non proliferative breast diseases do not increase risk of cancer [1]. However, proliferative breast diseases with or without atypia confers mild and moderate risk respectively, whereas carcinoma in situ is associated with substantial risk of life if left untreated [2].The carcinomas often have a poor prognosis due to high rate of local recurrence as well as metastasis, necessitating surgery in some cases adjuvant to chemotherapy [3].The canine mammary tumor (CMT) account for between 25 to 50 percent of all the tumors occurring in the canines [4][5][6] and are only second to skin tumors [7].…”