Fine needle aspiration cytology for lymph nodes: a three-year study

Zhou, Jian; Li, Feng; Meng, Lianying; Hao, Fengyun; Liu, Xi-Shuang; Zhao, Cheng; Zhang, Kejun; Dong, Anbing

doi:10.1080/09674845.2016.1144947

Cited by 18 publications

(19 citation statements)

References 15 publications

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“…This high rate has been similarly reported by sev- eral studies in developing countries [1,3,4]. On the contrary, in developed countries, malignant tumors are the first cause of cervical lymphadenopathy [5].…”

Section: Discussionsupporting

confidence: 55%

Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis

et al. 2018

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Objective: This study assesses the role of fine-needle aspiration cytology (FNAC) in the diagnosis of tuberculous lymphadenitis (TL) in comparison with histology and bacteriology findings. Study Design: We undertook a descriptive retrospective study of 937 FNAC specimens from 851 patients with cervical lymph nodes. The FNAC findings were then compared to histopathology and bacteriology. Results: Of the 937 aspirates, the cytopathological diagnoses consisted of 426 (55.9%) TL, 185 (24.3%) reactive lymphoid hyperplasia, 18 (2.3%) suppurative inflammation, 78 (10.2%) malignant metastatic tumor, and 54 (7%) lymphoma. Of the 426 TL cases, 171 were diagnosed by FNAC combined with bacteriological examination. In this group, 22 cases were found to be positive on Ziehl-Neelsen stain and 16 by culture. A histopathology report was available for 62 cases. Compared to histopathology, the overall diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of FNAC in the diagnosis of cervical TL were, respectively, 96.77, 100, 100, and 96.67%. When comparing bacteriology to histopathology, these values were 97.44, 100, 100, and 91.67%. Conclusion: Our study shows that FNAC is a sensitive and specific tool for the diagnosis of cervical TL.

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Section: Discussionsupporting

confidence: 55%

Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis

et al. 2018

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“…This may be due to higher prevalence of tuberculosis in our country . In other ethnic groups, metastatic tumors were found to be the most common cause of cervical lymphadenopathy in FNAC . Considering histology as the gold standard, FNAC has been found to have a very low FN rate, consisting in 0.2% of negative cases in our review.…”

Section: Discussionmentioning

confidence: 68%

Accuracy of fine‐needle aspiration cytology of head and neck masses

Rammeh

Romdhane

Sassi

et al. 2018

Diagnostic Cytopathology

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Background Head and neck masses are a common presentation in daily practice and can be challenging to both clinicians and cytopathologists. Fine needle aspiration cytology (FNAC) is a widely used method for the diagnosis of head and neck masses. The aim of the study was to assess our institutional experience of the accuracy of FNAC in the diagnosis of head and neck masses. Methods A total of 1262 FNACs were conducted from January 2013 to December 2016 and subdivided into benign and malignant categories. The thyroid and salivary glands FNACs were classified according to the Bethesda System for Reporting Thyroid cytopathology and to the Milan System for Reporting Salivary Gland Cytopathology respectively. The measures of diagnostic accuracy of FNAC were determined taking histology as a gold standard. Results A total of 7 false negative (FN) and 6 false positive (FP) FNACs were identified. Overall sensitivity and specificity of FNAC for a malignant diagnosis were 92% and 94.4%, respectively. Accuracy of FNACs of head and neck masses was 93.5% for all sites. The salivary gland group had the highest rate of FN (2.8%). All FP were reported in the thyroid group. These cases were cytologically classified suspicious for malignancy (n = 3) and papillary carcinoma (n = 3) and proved to be lymphocytic thyroiditis on final histology. Among the most common locations, cytology of lymph nodes provided the best sensitivity (98.2%). Salivary glands as well as lymph nodes had the best specificity (100%). Conclusion FNAC of head and neck masses has a high accuracy allowing a correct therapeutic management. However, this accuracy depends on the anatomic location of the mass.

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“…In 2015, Wang et al [71] reported using this method to detect levels of the mRNA of a transcription factor (Snail) in pancreatic cancer. In issue 1 this year, Zhou et al [72] reported the result of FNAC examination of 2136 lymph nodes from 1362 patients with lymphadenopathy. The most common findings were metastatic tumours (present in 53.6% (far more prevalent in males [675 from 1178] than in females [470 from 958, chi-squared p < 0.001]), chronic non-specific lymphadenitis (15.2%) tuberculous lymphadenitis (8.7%) and reactive lymphadenitis (7.5%).…”

Section: Cytopathologymentioning

confidence: 99%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

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In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

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Fine needle aspiration cytology for lymph nodes: a three-year study

Abstract: Lymphadenopathy is associated with a wide range of disorders; however, metastatic lymph nodes of malignancies are the most common cause for enlarged lymph nodes.

Cited by 18 publications

References 15 publications

Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis

Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis

Accuracy of fine‐needle aspiration cytology of head and neck masses

British Journal of Biomedical Science in 2016. What have we learned?

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