Fine-needle aspiration biopsy of skeletal versus extraskeletal osteosarcoma

Nicol, Kathleen; Ward, William G.; Savage, Paul; Kilpatrick, Scott E.

doi:10.1002/(sici)1097-0142(19980625)84:3<176::aid-cncr10>3.0.co;2-r

Cited by 43 publications

(26 citation statements)

References 17 publications

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“…Correlation with clinicoradiologic features and the presence of matrix material allows for the speci® c diagnosis of osteosarcoma. Nevertheless, in our experience and others, the appearance of the matrix material in both DiÚ -Quik 1 and Papanicolaou preparations is relatively nonspeci® c [1,2,10]. Matrix material is observed best in Romanowsky-type (DiÚ -Quik 1 stain) stains and usually appears metachromatic to magenta.…”

Section: Discussionsupporting

confidence: 46%

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The Role of Fine Needle Aspiration Biopsy in the Diagnosis and Management of Osteosarcoma

Kilpatrick

Ward

Bos

et al. 2001

Pediatric Pathology and Molecular Medicine

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& We retrospectively reviewed our experience with ® ne needle aspiration biopsy (FNAB) in the diagnosis and management of skeletal osteosarcoma. The bi-institutional study sample involved 30 consecutive aspirates from 29 patients (28 primary tumors, 1 pulmonary metastasis, 1 local recurrence). There were 17 children and 12 adults. Two aspirates were unsatisfactory for diagnosis. Of the adequate primary osteosarcomacases analyzed by FNAB, 24 of 26 were diagnosedas osteosarcoma.All pediatriccases were correctly interpreted as osteosarcoma and treated appropriately. There were 2 incomplete diagnoses. A secondaryosteosarcomaarising within an otherwise clinically, radiologically,and histologically typical giant cell tumor (malignant giant cell tumor) was not diagnosed preoperatively on FNAB due to nonrepresentative sampling. Chronologically, the ® rst patient with osteosarcoma analyzed by FNAB was diagnosed simply as``spindle cell neoplasm.' ' No complications resulted from the procedure. With adequate clinical and radiologic correlation, FNAB represents a technically, easily performed, cost-eÚ ective, and accurate procedure for establishing the diagnosis of skeletal osteosarcoma. Immediate interpretation of aspirated material allows for therapy planning and oncologic consultation at the initial clinic visit.

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Section: Discussionsupporting

confidence: 46%

“…It also is adequate as the primary diagnostic tool for enrollment of clinically eligible patients for therapeutic protocols [4± 7]. This study represents an expansion of our previously reported experience with FNAB in the diagnosis and management of osteosarcoma with emphasis on the acuracy of the technique and its usefulness in the pediatric population [1].…”

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confidence: 99%

The Role of Fine Needle Aspiration Biopsy in the Diagnosis and Management of Osteosarcoma

Kilpatrick

Ward

Bos

et al. 2001

Pediatric Pathology and Molecular Medicine

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“…Another cause of difficulty in accurately assessing the presence of osteoid in the smears is that osteoid, cartilage and dense collagen fibers appear very similar in both Diff-Quick and PAP stains. Furthermore, osteoid resists the suction, during aspiration, and when aspirated, the small, disrupted fragments lack the characteristic lattice-like pattern observed in histological sections (Mertens & Langnickel, 1982;Nikol et al, 1998).…”

Section: The Use Of Cytology In the Preoperative Investigation Of Bonmentioning

confidence: 99%

Histopathology and Molecular Pathology of Bone and Extraskeletal Osteosarcomas

Trihia¹,

Valavanis²

2012

Osteosarcoma

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“…This patient, a 16-year-old girl, reportedly had an adrenal adenoma removed as a young child ; her mother had a history of breast carcinoma and an extraskeletal osteosarcoma of the thigh. Both the mother and daughter have been discussed at length previously [ 1] .…”

Section: R Esults C Linical F Eaturesmentioning

confidence: 99%

“…It also is adequate as the primary diagnostic tool for enrollment of clinically eligible patients for therapeutic protocols [4][5][6][7] . This study represents an expansion of our previously reported experience with FNAB in the diagnosis and management of osteosarcoma with emphasis on the accuracy of the technique and its usefulness in the pediatric population [ 1] .…”

mentioning

confidence: 99%

The Role of Fine Needle Aspiration Biopsy in the Diagnosis and Management of Osteosarcoma

Kilpatrick¹

2000

Pediatric Pathology & Molecular Medicine

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retrospectively reviewed our experience with ne needle aspiration biopsy ( FN AB) in the & We diagnosis and management of skeletal osteosarcoma. T he bi-institutional study sample involved 30 consecutive aspirates from 29 patients ( 28 primary tumors, 1 pulmonary metastasis, 1 local recurrence) . T here were 17 children and 12 adults. T wo aspirates were unsatisf actory for diagnosis. Of the adequate primary osteosarcoma cases analyzed by FN A B, 24 of 26 were diagnosed as osteosarcoma. A ll pediatric cases were correctly interpreted as osteosarcoma and treated appropriately. T here were 2 incomplete diagnoses. A secondary osteosarcoma arising within an otherwise clinically, radiologically, and histolog ically typical giant cell tumor ( malignant giant cell tumor) was not diagnosed preoperatively on FN AB due to nonrepresentative sampling. Chronolog ically, the rst patient with osteosarcoma analyzed by FN AB was diagnosed simply as ''spindle cell neoplasm.'' N o complications resulted from the procedure. With adequate clinical and radiologic correlation, FN AB represents a technically, easily performed, cost-eå ective, and accurate procedure f or establishing the diagnosis of skeletal osteosarcoma. Immediate interpretation of aspirated material allows f or therapy planning and oncolog ic consultation at the initial clinic visit.

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Fine-needle aspiration biopsy of skeletal versus extraskeletal osteosarcoma

Cited by 43 publications

References 17 publications

The Role of Fine Needle Aspiration Biopsy in the Diagnosis and Management of Osteosarcoma

The Role of Fine Needle Aspiration Biopsy in the Diagnosis and Management of Osteosarcoma

Histopathology and Molecular Pathology of Bone and Extraskeletal Osteosarcomas

The Role of Fine Needle Aspiration Biopsy in the Diagnosis and Management of Osteosarcoma

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