Histopathology and Molecular Pathology of Bone and Extraskeletal Osteosarcomas

Trihia, Helen; Valavanis, Christos

doi:10.5772/31431

Cited by 6 publications

(12 citation statements)

References 221 publications

(184 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…It is estimated that the risk of developing osteosarcoma in irradiated bone is 0.03-0.08% [4]. It can develop in any irradiated bone, with most common locations being the pelvis and the shoulder [4].…”

Section: Discussionmentioning

confidence: 99%

“…Post-radiation sarcoma accounts for 0.5% to 5.5% of all sarcomas [3 of Noh] and 50-60% of radiation-induced sarcomas are osteosarcomas [4]. It is estimated that the risk of developing osteosarcoma in irradiated bone is 0.03-0.08% [4].…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, its hallmark is the production of osteoid, an unmineralized bone matrix that histologically appears as eosinophilic, dense, homogenous, amorphous and curvilinear intercellular material, somewhat refractile [4]. In osteoblastic osteosarcoma, the bone/ osteoid matrix contains pleomorphic malignant cells and coarse neoplastic woven bone [4]. The neoplastic bone varies in quantity and is deposited as primitive, disorganized trabecular and coarse, lace-like patterns, thin, arborizing lines of osteoid interweaving between neoplastic cell, as we observed in our case, or broad, large sheets of coalescing, trabeculae [4].…”

Section: Discussionmentioning

confidence: 99%

“…In osteoblastic osteosarcoma, the bone/ osteoid matrix contains pleomorphic malignant cells and coarse neoplastic woven bone [4]. The neoplastic bone varies in quantity and is deposited as primitive, disorganized trabecular and coarse, lace-like patterns, thin, arborizing lines of osteoid interweaving between neoplastic cell, as we observed in our case, or broad, large sheets of coalescing, trabeculae [4]. We also observed a strong positivity for CD56, a neuroectodermal marker usually expressed by aggressive osteosarcomas [9].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Postradiation Osteoblastic Osteosarcoma in the Iliac Region: Report of a Case with Multiple Cancers

Butorano¹,

Baldino²,

Orl³

et al. 2015

J Cytol Histol

View full text Add to dashboard Cite

Although rare, osteosarcoma is the most frequent post-radiation second malignancy of the bone. We present a case of an osteoblastic osteosarcoma that occurred in a woman with a history of two neoplasms, as an example of multiple treatment-associated neoplasms. In fact, prior to the development of this osteosarcoma, our patient had been diagnosed with a breast carcinoma 24 years earlier, which had been treated by quadrantectomy, followed by radiotherapy, but it had recurred after 7 years. Thus, the patient had undergone mastectomy, followed by 4 years of tamoxifen. Then, 14 years later, she developed the second tumor, an endometrial adenocarcinoma, which was treated by surgery and adjuvant radiotherapy. Afterwards, a neoplasm developed in the pelvic bones, which histologically proved to be an osteosarcoma. Athough considered low, there is some risk of developing an endometrial cancer after tamoxifen protracted therapy. Since germline mutation analyses for p53 and RB1 resulted negative in our case, Thus, the treatment could have played a prominent role in our patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Postradiation Osteoblastic Osteosarcoma in the Iliac Region: Report of a Case with Multiple Cancers

Butorano¹,

Baldino²,

Orl³

et al. 2015

J Cytol Histol

View full text Add to dashboard Cite

show abstract

Pathological and clinical features of primary osseous tumours of the jaw

Sarkar¹

2014

Journal of Bone Oncology

View full text Add to dashboard Cite

show abstract

Extraskeletal osteosarcoma of the larynx: an extremely unusual tumour

et al. 2014

View full text Add to dashboard Cite

Osteosarcoma of the larynx is probably the rarest mesenchymal tumour of the larynx, with only 16 cases reported so far. The majority of them occur in males between the sixth and eighth decades of life. Patients usually present with non-specific symptoms such as dysphonia and upper airway compromise. The most common site of distant metastasis is the lung. Clinically, the tumour follows an aggressive course and is associated with high mortality. The case we present is unusual as it occurred at a young age (38 years) as compared with the norm and it did not arise from the endolarynx, unlike many of the other cases. This was the only known case where a Pearson near-total laryngectomy was performed whereby the patient's natural speech mechanism was preserved. This surgery was possible because the contralateral half of the larynx was clearly disease free and the interarytenoid region was uninvolved. The patient underwent postoperative adjuvant external beam radiotherapy beginning 4 weeks after surgery. The patient is doing well after 15 months of follow-up and shows no signs of recurrence.

show abstract

Histopathology and Molecular Pathology of Bone and Extraskeletal Osteosarcomas

Cited by 6 publications

References 221 publications

Postradiation Osteoblastic Osteosarcoma in the Iliac Region: Report of a Case with Multiple Cancers

Postradiation Osteoblastic Osteosarcoma in the Iliac Region: Report of a Case with Multiple Cancers

Pathological and clinical features of primary osseous tumours of the jaw

Extraskeletal osteosarcoma of the larynx: an extremely unusual tumour

Contact Info

Product

Resources

About