Finding the Limits of Magnetic Hyperthermia on Core-Shell Nanoparticles Fabricated by Physical Vapor Methods

Abstract

Magnetic nanoparticles can generate heat when exposed to an alternating magnetic field. Their heating efficacy is governed by their magnetic properties that are in turn determined by their composition, size and morphology. Thus far, iron oxides (e.g., magnetite, Fe3O4) have been the most popular materials in use, though recently bimagnetic core-shell structures are gaining ground. Herein we present a study on the effect of particle morphology on heating efficiency. More specifically, we use zero waste impact methods for the synthesis of metal/metal oxide Fe/Fe3O4 nanoparticles in both spherical and cubic shapes, which present an interesting venue for understanding how spin coupling across interfaces and also finite size effects may influence the magnetic response. We show that these particles can generate sufficient heat (hundreds of watts per gram) to drive hyperthermia applications, whereas faceted nanoparticles demonstrate superior heating capabilities than spherical nanoparticles of similar size.

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

“…There are several problems associated with hyperthermia nowadays. The main problems are related to nonselective heating up of tissues and not reaching a high enough temperature [ 102 , 103 ]. Therefore, attempts have been made to overcome these problems.…”

“…In addition, magnetite is easy to manipulate to obtain the desired effect. The heating of the magnetite depends on the frequency and amplitude of the applied magnetic field and the size, morphology, and composition of the magnetic nanoparticles [ 103 , 108 ]. In addition to microwave radiation (magnetic hyperthermia), magnetite can be induced with the use of a laser (photothermal) [ 109 ].…”

An accurate standardization protocol for heating efficiency determination of 3D printed magnetic bone scaffolds

“…On the other hand, figure 8 shows the normalized (given in Watts per iron gram) SLP values (presented by green bars and refer to as the right green vertical axis) for the three different MBS samples. The purple zone, shown also in figure 8 and corresponds to the right vertical axis, refers to the respective normalized SLP, derived from magnetic hyperthermia measurements of single magnetite nanoparticles taken under the same field and frequency conditions (24 kA•m −1 and 365 kHz respectively) [36]. Martinez-Boubeta et al have shown in their work [36] that the calculated SLP (given by the hysteresis area from the minor hysteresis loop), as well as the experimental measured SLP of single ferromagnetic magnetite nanoparticles, were both 50 W g −1 .…”

Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography

“…The results in this paper demonstrate the potential of this new methods to provide images of GNPs in the tumor cells. Furthermore, the proposed system can potentially be used with iron-oxide nanoparticles [39]. However, the size of these particles is larger than 5 nm in diameter.…”