Numerical simulation is performed in this study to explore filmcooling enhancement by injecting mist into the cooling air with a focus on investigating the effect of various modeling schemes on the simulation results. The effect of turbulence models, dispersed-phase modeling, inclusion of different forces (Saffman, thermophoresis, and Brownian), trajectory tracking, and mist injection scheme is studied. The effect of flow inlet boundary conditions (with/without air supply plenum), inlet turbulence intensity, and the near-wall grid density on simulation results is also included. Using a 2-D slot film cooling simulation with a fixed blowing angle and blowing ratio shows a 2% mist injected into the cooling air can increase the cooling effectiveness about 45%. The RNG k-ε model, RSM and the standard k-ε turbulence model with the enhanced wall treatment produce consistent and reasonable results while the turbulence dispersion has a significant effect on mist film cooling through the stochastic trajectory calculation. The thermophoretic force slightly increases the cooling effectiveness, but the effect of Brownian force and Saffman lift is imperceptible. The cooling performance is affected negatively by the plenum in this study, which alters the velocity profile and turbulence intensity at the jet exit plane. The results of this paper can serve as the qualification reference for future more complicated studies including 3-D cooling holes, different blowing ratios, various density ratios, and rotational effect.