Film Coating as a New Approach to Prepare Tablets Containing Long-Term Stable Lactobacillus acidophilus

Abstract

Abstract

Immobilization of vaginal Lactobacillus in polymeric nanofibers for its incorporation in vaginal probiotic products

“…The drying processes decrease the water content and thus the weight of the formulation and the storage place, in a way to facilitate the handling of probiotic cells and their controlled dosing (Coghetto et al, 2016). Even though lyophilization and spray-drying are the drying systems most frequently applied (Broeckx et al, 2016;Juárez Tomás et al, 2009;Vera Pingitore et al, 2015), the applicability of the powder obtained from these processes is limited to vaginal tablets, capsules and insert (De Gregorio et al, 2020b;Vitali et al, 2016;Wagner et al, 2015). In addition, the lyophilization includes several drawbacks as long time required for drying, low energy efficiency, high cost of purchase and maintenance of the equipment, and sensitivity of the product to the freezing and other processing-related stresses (Walters et al, 2014).…”