Field trial on the post-insemination intrauterine treatment of dairy cows with mild endometritis with cephapirin

Schlegl, Roland; Drillich, M.; Ballas, Panagiotis; Reinländer, Ulrike; Iwersen, M.; Baumgartner, Walter; Ehling‐Schulz, Monika; Wagener, Kenneth B.

doi:10.1016/j.theriogenology.2020.06.024

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Clinical endometritis (CE) is defined as an inflammation of the endometrium with the presence of purulent or mucopurulent vaginal discharge, detectable more than 21 days after parturition (Sheldon et al., 2006). The identification of the main pathogens related to CE contributes to the use of selective therapy, strategically treating only cows affected by such microorganisms, reducing the use of antibiotics in dairy production (Pascottini et al., 2020; Schlegl et al., 2020). Previous studies have reported that one of the main bacteria associated with CE in dairy cows is Trueperella pyogenes and the severity of the injuries caused by these bacteria in the uterine environment directly impacts the profitability of the farms and may even cause the early culling or death of the affected animal (Galvão et al., 2019; Pascottini et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Clinical endometritis with Trueperella pyogenes reduces reproductive performance and milk production in dairy cows

Paiano

Bonilla

Moreno

et al. 2021

Reprod Domestic Animals

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The aim of this study was to identify the impact of Trueperella pyogenes in cows with clinical endometritis (CE) on reproductive performance and milk production in affected cows. In total, 230 lactating Holstein dairy cows from six commercial dairy herds were sampled once between 28 and 33 days post‐partum. Cows included in the present study did not receive antibiotic or anti‐inflammatory treatments prior to the experimental period. Clinical endometritis (CE) was characterized as cow with vaginal mucus score = 3 (>50% of purulent vaginal discharge) and >18% polymorphonuclear neutrophilic leukocyte (PMNL). The body condition scores (BCS) and milk production were evaluated at the time of enrolment. The identification of isolated bacteria was carried out through the analysis of MALDI‐TOF MS (matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry). According to uterine health, three groups of dairy cows were formed: healthy control cows without T. pyogenes (n = 147), CE cows with T. pyogenes (n = 22) and CE cows without T. pyogenes (n = 61). CE cows with T. pyogenes had lower BCS, milk production and conception at first AI (p < .01) than CE cows without T. pyogenes and control cows. Furthermore, CE cows with T. pyogenes had higher (p < .01) service per pregnancy and had greater (p < .01) days to get pregnant than CE cows without T. pyogenes and control cows. This study demonstrates that CE cows with T. pyogenes had impaired reproductive performance and milk production when compared to cows without CE and CE cows without T. pyogenes. This information can contribute to a strategic treatment in cows affected by clinical endometritis, favouring the rational use of antibiotics on dairy farms.

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Section: Introductionmentioning

confidence: 99%

Clinical endometritis with Trueperella pyogenes reduces reproductive performance and milk production in dairy cows

Paiano

Bonilla

Moreno

et al. 2021

Reprod Domestic Animals

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“…In a recent study, common uterine pathogens were rarely detected, and the composition and diversity of the microbiota consisted of Staphylococcus , Bacillus , and Streptococcus spp. in the uterus of cows with mild endometritis [ 45 ].…”

Section: Predisposing Factors For Persistent Endometritis In Cowsmentioning

confidence: 99%

Predisposing factors, diagnostic and therapeutic aspects of persistent endometritis in postpartum cows

Osawa

2021

Journal of Reproduction and Development

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A certain level of endometrial bacterial infection and inflammation is involved in bovine uterine involution during the puerperal period. Factors that hamper normal uterine involution expose the uterine environment to pathological conditions, causing different endometritis levels. The lack of proper diagnostic tools extends the time to conception. Efforts have been made to elucidate the postpartum uterine environment, including bacterial flora, changes in transient endometrial inflammation, and the pathophysiology of endometritis, to improve bovine reproductive performance. E. coli and Trueperella pyogenes in the uterus are likely to cause persistent infection, and Mycoplasma bovigenitalium infection is associated with dystocia and cytological endometritis in postpartum dairy cows. Due to the widespread use of cytobrush as a diagnostic tool for bovine subclinical endometritis (SE) that enables quantification of the degree of inflammation, we found that endometritis at week 5 postpartum was associated with delayed first ovulation. Approximately 30% of open cows have SE during the postpartum period, and cows with low blood glucose during prepartum have a high risk of developing SE. Additionally, cows with purulent vaginal discharge do not always have endometritis but only vaginitis and/or cervicitis. Intrauterine infusion of polyvinylpyrrolidone-iodine (PVP-I)improves fertility and promotes endometrial epithelial cell regeneration after inducing transient uterine inflammation, suggesting that PVP-I could be a good alternative to antibiotics. In conclusion, prepartum management to prevent glucose deficiency, prompt diagnosis to identify causative agents and intrauterine inflammation levels, and appropriate treatment to minimize antimicrobial resistance is beneficial for tackling endometritis and improving reproductive performance in bovine herds.

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“…The practice of veterinary medicine in recent years has registered a trend towards the spread of obstetric and gynecological diseases in domestic animals (Potter et al, 2010). For the treatment of females with obstetric and gynecological pathology, more than 50 thousand different compounds are used, of which more than eight thousand are antibacterial in nature (Roman Rudakov, Liliya Khamitova, Anastasiya Metlyakova & Vyacheslav Milaev, 2020).…”

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confidence: 99%

Comprehensive methods of diagnosis and prevention of postpartum complications in cows

Abubakari

2020

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The experiments were conducted during 2018 - 2020 on cows of black-spotted breed in the conditions of LLC "Ryasnyanske" of Krasnopil district of Sumy region. Cows were aged 4 - 8 years with an average annual milk yield of 2.5 - 3.1 thousand kg of milk per lactation. Assessment of the postpartum period was performed according to the changes that occurred in the female reproductive system. This took into account not only the general condition of the animals, the nature of the exudate, the size and topography of the uterus, but also the condition of the ovaries, cervix and vagina in rectal and vaginal examinations. Diagnosis of various forms of endometritis was performed based on medical history, clinical and gynecological studies. For the treatment of cows of the experimental group with postpartum endometritis, they were injected subcutaneously with 10 ml of the drug "Metrisan" in a mixture with 0.5% solution of novocaine at a rate of 1: 1. The interval between injections was 7-10 days. The frequency depended on the form of endometritis and was 3-5 injections. For the treatment of cows of the control group with postpartum endometritis they used a 10% solution of ichthyol intrauterinely Injection of 7% solution of ichthyol into pararectal tissue In 2018, 2 cows (1.6%) dropped out for this reason, in 2019 - 4 heads (3.1%), in 2020 -4 cows (2.8%). Due to age-related infertility, 1 cow was culled in 2018 (0.8%), 2 cows were culled in 2019 (1.3%), and 2 heads were culled in 2020 (1.4%). Due to injuries in 2018, 1 cow was discarded (0.8%), in 2019 1 cow was culled (0.8%), in 2020 1 cow was culled (0.7%). In 2018, the most common pathology of the postpartum period was vulvo vaginitis 8%, endometritis - 6.5%, artificially acquired infertility - 0.8%. In 2019, 9.8% of cows had endometritis; vaginitis, vulvitis, cervicitis - 8.3%, artificially acquired infertility was 0.8%. In 2020, endometritis was 17%, vaginitis, vulvitis, cervicitis - 9.2%, artificially acquired infertility was 0.8. According to the results of the research, the therapeutic efficacy was higher in the experimental group, where the therapy of cows with acute purulent-catarrhal endometritis using the drug sepranol and amoxicillin-150 was used. The total number of days of infertility in the control group was 125 days, in the experimental - 60 days. In terms of 1 head it is: in the control group - 25 days, in the experimental -12 days. The duration of the period from birth to fertilization in the control group is 55 days, in the experimental group - 42 days.

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Field trial on the post-insemination intrauterine treatment of dairy cows with mild endometritis with cephapirin

Cited by 4 publications

References 39 publications

Clinical endometritis with Trueperella pyogenes reduces reproductive performance and milk production in dairy cows

Clinical endometritis with Trueperella pyogenes reduces reproductive performance and milk production in dairy cows

Predisposing factors, diagnostic and therapeutic aspects of persistent endometritis in postpartum cows

Comprehensive methods of diagnosis and prevention of postpartum complications in cows

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