Predisposing factors, diagnostic and therapeutic aspects of persistent endometritis in postpartum cows

Osawa, Takeshi

doi:10.1262/jrd.2021-052

Cited by 16 publications

(10 citation statements)

References 80 publications

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“…Endometritis is inflammation of the endometrial lining of the uterus. Endometritis generally occurs after 20 days postpartum, very abnormal parturition (Rouse et al, 2019), such as abortion, retained placenta, premature birth, multiple births, dystocia, and injuries caused by tools used during less clean births (Osawa, 2021). Fetal death, seasonal factors, and bacterial infections were factors for endometritis in smallholder dairy farms (Lee et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Handling of endometritis in dairy cow after infection with foot and mouth disease and abortion

Amalia Nadila Faradillah,

Galuh Chandra Agustina

2023

Ovz

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This study aims to report the handling of endometritis in a dairy cow at Koperasi Agro Niaga Jabung, Malang, Indonesia. A Holstein Friesian cross heifer was diagnosed at 258 days pregnant and clinically suffering from Foot and Mouth Disease. On the 266th day of pregnancy, the fetus died, an abortion was diagnosed, and the delivery was assisted by the veterinarian. Furthermore, the cow was treated with 15 mL oxytetracycline intramuscularly. The next day, the veterinarian treated the retained placenta. On the third day after the abortion, the farmer reported that the cow had vaginal discharge which was cloudy white, reddish and smelled bad. The veterinarian treated the cow with an injection of 15 mL of Oxytetracycline. On the sixth day after the abortion, the farmer reported that vaginal discharge still coming out again. Clinical symptoms were, thick, purulent, cloudy, pink discharge from the vagina that hanged in the vulva area and smelled bad. Physical examination showed a body temperature of 40°C, and rectal palpation revealed the uterine wall to be thick, hard, stiff, and getting warmer. Furthermore, the cow was given intrauterine flushing with 1% povidone-iodine (diluted in distilled water), followed by intrauterine administration of 15 mL Oxytetracycline, analgesics, antipyretics, and antispasmodics. Fifteen mL of vitamin B12, ATP, and minerals (Magnesium, Potassium, Sodium selenite) was injected intramuscularly.

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Section: Discussionmentioning

confidence: 99%

Handling of endometritis in dairy cow after infection with foot and mouth disease and abortion

Amalia Nadila Faradillah,

Galuh Chandra Agustina

2023

Ovz

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“…According to individual authors (Pascottini et al, 2017;Wagener et al, 2021), from 14 to 40 % of calving cows are characterized by postpartum inflammation of the endometrium, which occurs in 21 or more days after calving (Sheldon et al, 2006). Other studies have found (Dubuc et al, 2010;Bradford et al, 2015;Osawa, 2021) that in some cases, postpartum endometritis occurs in 50 to 90 % of cows.…”

Section: Postpartum Pathology Of the Uterusmentioning

confidence: 99%

Postpartum complications in cows: diagnosis, treatment, prevention

Chabanenko,

Zhelavskyi,

Skliarov

et al. 2024

Ukr. Jour. of Vet. and Agr. Sci.

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This review contains an analysis of domestic and foreign researchers regarding the occurrence of postpartum complications in cows, which represents a significant veterinary problem. Diagnostic methods and treatment regimens for postpartum pathologies of various origins are presented. Difficulties and errors in diagnosing uterine inflammation lead to improper treatment, prolonged infertility, and significant economic losses. Based on an analysis of the literature, it has been proven that clinical forms of endometritis often develop into a subclinical course. The proportion of hidden endometritis can account for up to 80 % of the total amount of endometrial inflammation. The problem with postpartum complications of the uterus is that the inflammatory processes spread to the ovaries, and this can lead to complete infertility in animals. Rectal examination of cows remains one of the primary methods for diagnosing endometritis. Treatment generally involves the use of a wide range of antibiotics. Data on the hormonal causes of postpartum pathologies of the reproductive system of cows are also presented. A big problem is follicular and luteal cysts, their timely diagnosis and appropriate treatment. The leading cause of cysts is a disruption of the hypothalamic-pituitary-gonadal axis. A practical method for diagnosing cysts is ultrasound, and the type of cyst can be determined by the level of progesterone in the blood. A practical method of treating cysts is the use of hormonal drugs. Data are also presented confirming the significant role of microflora in the occurrence of inflammatory changes in the reproductive organs of cows. The main types of causative agents of inflammatory processes in the genital organs of cows in the postpartum period are given. In cows with endometritis, an imbalance of the uterine microflora is detected, and the growth of bacteria of the genus Bacteroidetes and Fusobacteria with a simultaneous decrease in the number of Proteobacteria and Tenericutes. Data are presented that rumen acidosis can cause inflammation of the uterus, and this is associated with the penetration of Fusobacterium necrophorum into the blood circulation. The effectiveness of intravaginal treatment of cows with a mixture of lactic acid bacteria (L. rhamnosus, P. acidilactici, and L. reuteri) has been shown.

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“…In addition to metabolism, genital tract microbiota has an essential effect in the occurrence and development of endometritis (Osawa, 2021 ). A previous study showed that mice with endometritis had increased relative abundances of Klebsiella , Lachnoclostridium_5 and Citrobacter , which may be responsible for endometritis (Dong et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Wang

et al. 2022

Microbial Biotechnology

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Endometritis is persistent inflammation caused by bacteria, which can lead to infertility. Although traditional Chinese medicine (TCM) has been used to treat endometritis, the underlying mechanism is still unclear. Here, Baogong Decoction (BGD), a TCM compound, was used to treat mouse endometritis induced by Escherichia coli (E. coli), and then 16S rRNA sequencing and non-targeted metabolomics were used to investigate the change of uterine microbiota and metabolomes in serum and uterine after BGD treatment.Finally, the therapeutic effect of potential metabolites for treating mouse endometritis screened by combined omics analyses was verified using pathological model. The results showed that BGD treatment could effectively treat endometritis associated with the increasing relative abundance of Firmicutes, Bacteroides, Lactobacillus and Lactococcus, and the decreasing relative abundance of Cupriavidus and Proteobacteria. 133 and 130 metabolites were found to be potential biomarkers in serum and uterine tissue respectively.In serum and tissues, dehydroepiandrosterone (DHEA) and catechol were significantly increased in the BGD treatment versus the inflammation group.Results of combined omics analyses demonstrated that DHEA was positively correlated with changes in microbiota. Results of pathological model demonstrated that DHEA could cure endometritis effectively associated with the decreasing infiltration of inflammatory cells and expression of inflammatory factors in the uterus. In summary, our results demonstrated that BGD could cure endometritis in mice by modulating the structure of the uterine microbiota and its metabolites, in which DHEA may be one of the main components of the therapeutic effect of BGD.

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Predisposing factors, diagnostic and therapeutic aspects of persistent endometritis in postpartum cows

Cited by 16 publications

References 80 publications

Handling of endometritis in dairy cow after infection with foot and mouth disease and abortion

Handling of endometritis in dairy cow after infection with foot and mouth disease and abortion

Postpartum complications in cows: diagnosis, treatment, prevention

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

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