Field trial of praziquantel for control of fishborne zoonotic trematodes in reservoir hosts in Vietnam

Anh, Nguyễn Thị Lan; Madsen, Henry; Thanh, Dao Thi Ha; Dalsgaard, Anders; Murrell, K. D.

doi:10.1016/j.vetpar.2010.08.035

Cited by 5 publications

(3 citation statements)

References 10 publications

(9 reference statements)

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“…Hence, the 5 dogs excreting damaged eggs were regarded cured of the FZT infection and the effectiveness of the treatment in the field to be 100%. In a previous study in dogs and cats where two different doses of praziquantel were evaluated, two cats receiving 75 mg/kg also showed damaged eggs 3 days post treatments that were judged non-viable [15]. We therefore reason that our assumption is valid.…”

Section: Discussionmentioning

confidence: 84%

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Reinfection of Dogs with Fish-Borne Zoonotic Trematodes in Northern Vietnam following a Single Treatment with Praziquantel

et al. 2014

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BackgroundFish-borne zoonotic trematodes (FZT) infections including liver- and minute intestinal flukes are common in Southeast Asia in both humans and domestic animals eating raw fish and since 2010, the liver flukes are recognised as neglected tropical diseases by WHO. Mass drug treatment with praziquantel is advised for humans, but no recommendations for control of the FZT in the reservoir hosts exist.Methodology/Principal FindingsA study was conducted to assess the ability of praziquantel treatment for control of FZT in farm dogs in an endemic area in Northern Vietnam. Initially, 101 dogs from 73 households were examined for small trematode eggs in their faeces. Forty seven copro-positive dogs were included in the study. Thirty eight dogs received treatment with a single dose of 40 mg/kg of praziquantel. A group of nine dogs were left untreated. Coprological examination for small trematode eggs was performed on day 0, 3, 10, 30, 60, 90 and 120 post treatment. Farmers were questioned about dog keeping practises. All dogs were copro-negative for small trematode eggs on both day 3 and 10 post treatment. From day 30 onwards previously negative dogs became positive again. The reinfection rates were 26.3% (day 30), 45.5% (day 60), 53.1% (day 90), 61.3% (day 120).The nine untreated dogs remained positive throughout the study period. There was no difference in the intensity of infection at day 0 and 120 neither in the treated or untreated group.ConclusionDogs had easy access to raw fish and did not receive treatment against flukes by their owner. More than 50% of the dogs were reinfected 3 months post treatment. We do not recommend controlling FZT infections in dogs by anthelmintic treatment alone since reinfection occurs fast under the existing farm management systems.

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Section: Discussionmentioning

confidence: 84%

“…A previous field trial with praziquantel also gave indications of dogs becoming copro-positive for small trematode eggs 30 days after treatment [15].…”

Section: Introductionmentioning

confidence: 96%

Reinfection of Dogs with Fish-Borne Zoonotic Trematodes in Northern Vietnam following a Single Treatment with Praziquantel

et al. 2014

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“…Dogs and cats are important reservoir hosts of many foodborne trematodes, including Opisthorchis spp. ; birds are reservoirs of some intestinal fluke species (Chai et al , 2005; Anh, 2009; Anh et al , 2010; Aunpromma et al , 2012). In 2003, Opisthorchis lobatus , a new species of Opisthorchis , was described in the intestines of ducks ( Anas sp.)…”

Section: Introductionmentioning

confidence: 99%

Opisthorchis viverrini-like liver fluke in birds from Vietnam: morphological variability and rDNA/mtDNA sequence confirmation

et al. 2013

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Flukes were found in the bile ducts of domestic ducks (Anas platyrhynchos), necropsied in the Binh Dinh province of Central Vietnam. Following staining, morphological characteristics of the bird flukes were compatible with Opisthorchis viverrini, although some characteristics differed from those described in specimens collected from mammal hosts. Computation of the phylogenetic trees on the partial sequences of the second internal ribosomal spacer (ITS2) of the ribosomal DNA and cytochrome c oxidase subunit I (COI) markers of the mitochondrial DNA showed close similarity of the 'bird' Opisthorchis sp. with O. viverrini. We speculate that these bird flukes are O. viverrini that show intraspecies morphological and molecular variability compared to isolates from mammals. This demonstrates the complex epidemiological situation of opisthorchiasis in Vietnam and urges investigations on the potential of birds as a reservoir host of this zoonotic fluke.

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Reservoir Animals and Their Roles in Transmission of Opisthorchis viverrini

Tangkawattana

2018

Advances in Parasitology

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Field trial of praziquantel for control of fishborne zoonotic trematodes in reservoir hosts in Vietnam

Cited by 5 publications

References 10 publications

Reinfection of Dogs with Fish-Borne Zoonotic Trematodes in Northern Vietnam following a Single Treatment with Praziquantel

Reinfection of Dogs with Fish-Borne Zoonotic Trematodes in Northern Vietnam following a Single Treatment with Praziquantel

Opisthorchis viverrini-like liver fluke in birds from Vietnam: morphological variability and rDNA/mtDNA sequence confirmation

Reservoir Animals and Their Roles in Transmission of Opisthorchis viverrini

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