Field-portable capillary electrophoresis instrument with potentiometric and amperometric detection

Kappes, Thomas; Schnierle, Peter; Hauser, Peter C.

doi:10.1016/s0003-2670(99)00149-x

Cited by 65 publications

(60 citation statements)

References 32 publications

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“…We know of one portable CE (P-CE) instrument that is currently commercially available (CE Resources, Singapore) [32]. However, several laboratory-built instruments have been pre-sented in the literature [31,[33][34][35]. Commercial P-CE instruments may not be more widely available because of the perception that CE is inferior in robustness to high-performance liquid chromatography (HPLC) [36].…”

Section: Portable Capillary Electrophoresismentioning

confidence: 99%

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Portable capillary-based (non-chip) capillary electrophoresis

Ryvolová

Preisler

Brabazon

et al. 2010

TrAC Trends in Analytical Chemistry

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Miniaturized, portable instrumentation has been gaining popularity in all areas of analytical chemistry. Capillary electrophoresis (CE), due to its main strengths of high separation efficiency, relatively short analysis time and low consumption of chemicals, is a particularly suitable technique for use in portable analytical instrumentation. In line with the general trend in miniaturization in chemistry utilizing microfluidic chips, the main thrust of portable CE (P-CE) systems development is towards chip-based miniaturized CE. Despite this, capillary-based (non-chip) P-CE systems have certain unmatched advantages, especially in the relative simplicity of the regular cylindrical geometry of the CE capillary, maximal volume-to-surface ratio, no need to design and to fabricate a chip, the low costs of capillary compared to chip, and better performance with some detection techniques. This review presents an overview of the state of the art of P-CE and literature relevant to future developments. We pay particular attention to the development and the potential of miniaturization of functional parts for P-CE. These include components related to sample introduction, separation and detection, which are the key elements in P-CE design. The future of P-CE may be in relatively simple, rugged designs (e.g., using a short piece of capillary fixed to a chip-sized platform on which injection and detection parts can be mounted). Electrochemical detection is well suited for miniaturization, so is probably the most suitable detection technique for P-CE, but optical detection is gaining interest, especially due to miniaturized light sources (e.g., light-emitting diodes).

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Section: Portable Capillary Electrophoresismentioning

confidence: 99%

“…While the concept of the compact CE design remained in the following work [35], AmpD was added to extend the applicability of the P-CE instrument. A further improvement of the detection system resulted in simpli-fied AmpD for this P-CE instrument [65].…”

Section: Research-based Portable Instrumentsmentioning

confidence: 99%

Portable capillary-based (non-chip) capillary electrophoresis

Ryvolová

Preisler

Brabazon

et al. 2010

TrAC Trends in Analytical Chemistry

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“…Membrane microelectrodes with liquid-state ion-exchangers, both for determination of cations [186] and anions [187], were fabricated by filling with a liquid membrane solution the tips of glass micropipette (diameter about 4 mm) and immersing directly in the membrane solution a Ag/AgCl internal reference electrode. PVC membrane electrodes for CE applications were also prepared by evaporation of appropriate membrane cocktail on the surface of a Pt disk of 90 mm diameter [188,189]. Miniature membrane electrodes with a solid contact were also used in CE determination of carboxylic acids.…”

Section: Potentiometric Detection In Cementioning

confidence: 99%

“…A copper electrode was employed for detection of amino acids [189] and inorganic and organic anions [191]. In the latter case a micromolar limit of detection was reported but indicated disadvantage was the etching and pilling of the surface of the copper electrode.…”

Section: Potentiometric Detection In Cementioning

confidence: 99%

“…Several different applications in CE voltammetry have been shown for metallic copper as a working electrode, for example in determination of amino acids [189], carbohydrate compounds [200], and enzymes [208]. Amperometric detection at a nickel electrode was applied in determination of polyhydroxy antibiotics [209].…”

Section: Amperometric and Voltammetric Detections In Cementioning

confidence: 99%

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Electroanalytical Flow Measurements–Recent Advances

2003

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As general trends in current development of chemical analysis, including electroanalysis, one can indicate a search for methods fast and multianalyte, for miniaturized measuring devices, mechanization and automation of analytical processes. In all these trends a significant role is played by measurements in flow conditions. The major advantage of flow electroanalysis is a possibility of utilizing a kinetic discrimination in potentiometric measurements and enhancement of mass transport in voltammetric techniques. Flow injection techniques provide shortening of time of a single analytical determination due to reproducible use of transient signal from the detector without need of obtaining a steady-state equilibrium signal. Electrochemical detection in HPLC gives often improved selectivity and detection limit for electroactive solutes, whereas in capillary electrophoresis it allows a convenient design of portable, integrated chips for field application. This review presents state-of-the -art of flow electroanalysis based on 226 cited literature references

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