Field Population-based blocking treatment of esophageal epithelia dysplasia

Hou, Jun; Lin, Pei-Zhong; Chen, Zhifeng; Ding, Zenghui; Li, Shao-Sheng; Men, Fan-Shu; Guo, Liping; He, Yutong; Qiao, Chui-Yun; Guo, Chui-Lan; Duan, Jianping; Wen, Di

doi:10.3748/wjg.v8.i3.418

Cited by 15 publications

(8 citation statements)

References 38 publications

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“…This herbal mixture has been shown to suppress aberrant crypt foci in an azoxymethane-induced rat colon cancer model, and also to induce apoptosis via the regulation of Bax (proapoptotic) and Bcl-2 (anti-apoptotic), ultimately leading to capase-9 activation. Clinical trials using Zeng Sheng Ping (ZSP) to treat oesophageal epithelial dysplasia have been performed in two Chinese districts with a high risk of oesophageal carcinoma (98,99). The results from these clinical trials have revealed the benefits of ZSP, which can reduce the incidence of cancer in high-risk groups with severe oesophageal epithelium dysplasia by 34.5-47.79% over a follow-up period of up to 9 years.…”

Section: Herbal Therapy For Precancerous Disordersmentioning

confidence: 99%

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

Jia

et al. 2015

Oncology Letters

120

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Abstract. Traditional Chinese medicine (TCM) has been a major part of healthcare in China, and has extensively affected medicine and healthcare in surrounding countries over a long period of time. In the fight against cancer, certain anticancer remedies using herbs or herbal formulas derived from TCM have been developed for the management of malignancies. Furthermore, there are clinical trials registered for the use of herbal remedies in cancer management. Herbal medicine has been used as part of combined therapies to reduce the side-effects of chemotherapy, including bone marrow suppression, nausea and vomiting. Herbal remedies have also been used as chemopreventive therapies to treat precancerous conditions in order to reduce the incidence of cancer in high-risk populations. Emerging evidence has revealed that herbal remedies can regulate the proliferation, apoptosis, adhesion and migration of cancer cells. In addition to this direct effect upon cancer cells, a number of herbal remedies have been identified to suppress angiogenesis and therefore reduce tumour growth. The inhibition of tumour growth may also be due to modifications of the host immune system by the herbal treatment. However, the precise mechanisms underlying the therapeutic effects of herbal remedies remain poorly understood and are yet to be fully elucidated. The present study aims to summarize the current literature and clinical trial results of herbal remedies for cancer treatment, with a particular focus on the recent findings and development of the Yangzheng Xiaoji capsule.

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Section: Herbal Therapy For Precancerous Disordersmentioning

confidence: 99%

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

Jia

et al. 2015

Oncology Letters

120

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“…In contrast to western countries, where the consumption of tobacco and alcoholic beverages has been implicated as a contributory factor in esophageal cancer, the causative factors in esophageal cancer in high-risk areas of China are summarized as follows: (i) nutrition deficiency, (ii) N-nitrosamines, (iii) fungi toxins, and (iv) genetic factors. For nearly 40 years, a great deal of cancer control work has been performed by Hebei Cancer Institute together with the Chinese Academy of Medical Sciences (Hou, 1989;Dong et al, 2002;Hou et al, 2002;Wang et al, 2002;Zhang et al, 2003;Lu et al, 2004). The National Eighth Five-Year, Ninth Five-Year, and Tenth Five-Year Scientific Championship Projects on the study of the prevention and treatment of esophageal cancer were carried out in Cixian.…”

Section: Men Womenmentioning

confidence: 99%

Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China

Hou

Chen

et al. 2008

European Journal of Cancer Prevention

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Incidence rates have risen for gastric cardia adenocarcinoma, whereas rates have remained stable for esophageal squamous cell carcinoma in many western countries. The aim of this study was to describe and analyze trends in incidence rates for esophageal cancer and gastric cardia cancer in Cixian county, which is one of the high-risk areas for esophageal cancer in China as well as in the world. The data were obtained from the Cixian Cancer Registry, which is a population-based registry. All the data were checked and analyzed using SPSS 11.5. Between the years 1988 and 2003 there were 11,183 cases of esophageal cancer in the county. The age-standardized incidence rate was 168.55 per 100,000. In 1988, the age-standardized incidence rate for male patients was 250.76/100,000; it declined to 160.05/100,000 in 2003, representing a decrease of 36.2%. The age-standardized incidence rate for female patients was 153.86/100,000 in 1988; it declined to 82.55/100,000 in 2003, showing a decrease of 46.3%. A slight decreasing trend was observed during the period, with a yearly decrease of 3.61% in male patients and 3.39% in female patients. For gastric cardia cancer, there were 1654 cases from 1988 to 2003. The age-standardized incidence rate was 25.58 per 100,000. The age-standardized incidence rate for male patients was 13.75/100,000 in 1988; it increased to 28.55/100,000 in 2003, with a yearly increase of 7.65%. The age-standardized incidence rate for female patients was 7.12/100,000 in 1988; it increased to 12.91/100,000, with a yearly increase of 5.44%. A statistically significant increasing trend of gastric cardia cancer was observed during the study period. Cixian county is a geographical region with a very high incidence of esophageal cancer and cardia cancer. The trend in the incidence rates of esophageal cancer had decreased slightly; on the other hand, gastric cardia cancer showed a significantly increased trend in the last 16 years. Detailed epidemiological analyses of demographic trends and risk factors will help to guide future cancer control strategies.

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“…(13)(14)(15) The study showed that TLD, Q, and H could inhibit cell proliferation. The amount of inhibition of cell proliferation was directly proportional to the concentration of each formula.…”

Section: Discussionmentioning

confidence: 99%

Tonglian Decoction (通莲汤) arrests the cell cycle in S-phase by targeting the nuclear factor-kappa B signal pathway in esophageal carcinoma Eca109 cells

Jia

et al. 2016

Chin. J. Integr. Med.

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Field Population-based blocking treatment of esophageal epithelia dysplasia

Abstract: ZSP can block the development from SEED I and SEED II to EC by 47.79%. Efforts should be made to screen and treat dysplasia cases in people aged 40 years and older in high risk areas to reduce the mortality figures.

Cited by 15 publications

References 38 publications

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China

Tonglian Decoction (通莲汤) arrests the cell cycle in S-phase by targeting the nuclear factor-kappa B signal pathway in esophageal carcinoma Eca109 cells

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