Fidgety movements in infants born very preterm: predictive value for cerebral palsy in a clinical multicentre setting

Abstract

Detection of infants at risk for later CP through FMA was good, but less robust when performed in a routine clinical setting; prediction improved when combined with neonatal cerebral ultrasound.

Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review

“…14 13,16,44,51,53,61,[67][68][69][70][71]77 Therefore, flow and follow-up rates could not be calculated accurately. Three studies used Hagberg or Palisano criteria to diagnose CP.…”

“…Touwen, Amiel-Tison, and Grenier) or a standard test of reflexes, tone, etc., were used to determine CP in 27 Review 483 studies. [16][17][18][38][39][40][41][42]44,45,48,[51][52][53][54][57][58][59]61,62,68,70,71,73,74,[78][79][80] Ten studies 13,43,46,50,63,64,67,72,76,77,85 used a non-specific neurological examination and were classified as unclear. Three studies 69,82-84 did not use standardized examinations between assessors and these were assigned a high risk of bias rating for the administration of the reference standard.…”

“…Twelve studies excluded infants if they had incomplete assessments. 13,16,44,51,53,61,[67][68][69][70][71]77 Therefore, flow and follow-up rates could not be calculated accurately. Table II summarizes the sensitivity, specificity, PPV and NPV ranges, positive likelihood ratios and negative likelihood ratios of cramped-synchronized, writhing, and fidgety movements assessed according to the Prechtl GMA and fidgety general movements according to Hadders-Algra, with individual study sensitivity and specificity detailed in Figure S1 (online supporting information).…”

“…SI (online supporting information). From the 47 included studies, we reproduced 292 data for 13 studies13,17,18,38,[41][42][43][44]52,64,68,77,83 for writhing movements, 26 studies13,14,16-18,38,39,41-44,46,48,52,54,56,59,64- 66,68,69,72,77,83,84 …”

Fidgety movements, cerebral palsy, and cognitive ability

“…They confirmed that absent fidgety movements predict CP with high sensitivity and specificity . Subsequently, Datta et al replicate this important finding by involving a large number of raters with different professional backgrounds in a multicenter study. More refined results, however, would likely require more limited numbers of experienced raters (e.g.…”