2010
DOI: 10.1016/j.actbio.2010.05.025
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Fibrous scaffolds loaded with protein prepared by blend or coaxial electrospinning

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Cited by 167 publications
(121 citation statements)
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“…This reduces the potential of electrospinning hydrophobic polymer nanofibers containing water-soluble drugs. Therefore, emulsion electrospinning 32,33 and coaxial electrospinning 34 have been developed for encapsulating water-soluble drugs. The electrospinning of water-soluble drug into a stable nanofibrous matrix well controls the drug diffusion into tissue and prolongs the effects of the drug.…”
Section: Fu Et Almentioning
confidence: 99%
“…This reduces the potential of electrospinning hydrophobic polymer nanofibers containing water-soluble drugs. Therefore, emulsion electrospinning 32,33 and coaxial electrospinning 34 have been developed for encapsulating water-soluble drugs. The electrospinning of water-soluble drug into a stable nanofibrous matrix well controls the drug diffusion into tissue and prolongs the effects of the drug.…”
Section: Fu Et Almentioning
confidence: 99%
“…Therefore, the aforementioned morphological characteristics coupled with controlled biomolecule delivery provide both morphological and biomedical applications for tissue regeneration. Nonetheless, research in this area is still quite limited [2][3][4][5][6][7][8][9][10][11][12], although the release pattern of pharmaceutical drugs with nanofibrous scaffolds has already been considered by a number of authors [13][14][15][16][17][18][19].…”
Section: Introductionmentioning
confidence: 99%
“…Blend [3], emulsion [5,10,20], and coaxial [3,9,12] electrospinning are three conventional electrospinning techniques for the incorporation of biomolecules into fibers. Researchers have reported burst release as a disadvantage of blend electrospinning comparing with coaxial electrospinning, which requires a special apparatus and careful selection of materials.…”
Section: Introductionmentioning
confidence: 99%
“…However, heterogeneous distribution, poor solubility, and loss of bioactivity of biomolecules during the blending are the major limitations of blend electrospinning [70]. In order to further examine the potential of biomolecules encapsulation by other electrospinning methods, several comparative studies between blend and co-axial electrospinning have been reported [66,67,71]. In a study by Ji et al, the bovine serum albumin (BSA) and alkaline phosphatase (AP) incorporated PCL scaffold was fabricated by blend and co-axial electrospinning [71].…”
Section: Emulsion Electrospinningmentioning
confidence: 99%
“…In order to further examine the potential of biomolecules encapsulation by other electrospinning methods, several comparative studies between blend and co-axial electrospinning have been reported [66,67,71]. In a study by Ji et al, the bovine serum albumin (BSA) and alkaline phosphatase (AP) incorporated PCL scaffold was fabricated by blend and co-axial electrospinning [71]. The fiber morphology, release kinetics of BSA and bioactivity of released alkaline phosphatase from both electrospun fibers were compared.…”
Section: Emulsion Electrospinningmentioning
confidence: 99%