Fibrous Dysplasia of the Axis

Stirrat, A. N.; Fyfe, I S; Fisher, Christine

doi:10.1097/00007632-198902000-00020

Cited by 19 publications

(10 citation statements)

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“…In spinal FD, the vertebral body is affected most frequently, owing to the relatively large amount of cancellous bone [7]. Because of the close relationship to the vertebral body, involvement of the pedicles has been described in nearly all cases in which the vertebral bodies are affected [12,15,[17][18][19]. In this study, lesions were located in the vertebral bodies and posterior elements or sacral bodies and alae of eight patients.…”

Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 85%

CT and MRI of fibrous dysplasia of the spine

Park¹,

Lee²,

Choi³

et al. 2012

BJR

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Objectives: The purpose of this study was to present the CT and MRI findings of patients with fibrous dysplasia (FD) of the spine. Methods: Among the patients with pathologically proven skeletal FD, 12 (8 males and 4 females; mean age, 43 years) who were evaluated with either spine CT or MRI were included. The number and location of the involved vertebral segments, the presence of lytic lesions, ground-glass opacity (GGO), an expansile nature, cortical disruption, a sclerotic rim, a decrease in body height and contour deformity were examined on CT scans (n512), while signal intensity, enhancement patterns and the presence of a dark signal rim on the lesion were examined using MRI (n59). Results: Nine patients had polyostotic FD, including one with an isolated spinal localisation, while three had monostotic FD. An expansile nature (n53) and osteolytic lesions with GGO (n53) were seen. On CT images, GGO was noted in all patients. An expansile nature (n511) and presence of lytic lesions (n511) were noted. A decrease in body height (n59) and sclerotic rim formation (n59) were indicated. Contour deformities were visible in six patients. The MRI findings were non-specific. Dark signal rims were visible on MRI in seven patients. Conclusion: Typical imaging findings of extraspinal FD were noted on spine CT scans. These characteristic CT imaging findings of spinal FD may be helpful in differentiating FD from other common spine diseases. Fibrous dysplasia (FD) is a developmental defect of osteoblastic differentiation and bone maturation of unknown origin [1]. FD may affect the skeleton either in isolation (monostotic FD, rate, 70-80%; and polyostotic FD, rate, 20-30%) or in variable combination with endocrine and cutaneous abnormalities (McCune-Albright syndrome) [2][3][4][5]. Although patients afflicted with FD may present at any age, they are typically young and in the first and second decades of life [6]. After puberty, dysplastic areas rarely expand [7]. In general, the progression of the skeletal lesions tends to be exhausted once patients have reached adult age [7]. The diagnosis of FD is difficult in adult patients because cases in older patients, especially those involving the spine, are rare.FD represents approximately 7% of all benign tumourlike bone lesions [8]. However, the spine is affected in only 2.5% of cases, and FD of the spine is very rarely observed without there being disease elsewhere in the body [9]. Spinal involvement occurs mostly in the polyostotic form of FD; it is unusual for it to occur in the monostotic form [9,10]. When present in the elderly with multiple vertebral lesions, a biopsy may be indicated because metastatic disease or multiple myeloma may simulate a benign non-aggressive process. Therefore, active diagnosis and radiological familiarity of spinal FD are thought to be essential for preventing unnecessary examinations or procedures.The purpose of this study was to present the CT and MRI findings of spinal FD, which is rare, and to assess the efficacy of CT in the diagnosis of FD. Me...

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Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 85%

CT and MRI of fibrous dysplasia of the spine

Park¹,

Lee²,

Choi³

et al. 2012

BJR

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“…However, the vertebral body has, in comparison to the other parts of the vertebra, the biggest amount of cancellous bone. Due to their close relationship to the vertebral body, involvement of the pedicles has been described in nearly all cases of body aVection [5,7,12,13,[15][16][17][19][20][21][22]. It could therefore be a possibility that Wbrous dysplasia in the spine starts in the vertebral Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Whether treatment of Wbrous dysplasia in cervical spine is necessary is controversial [5,7,12,13,[15][16][17][19][20][21][22]. If there is a mechanical reason for the pain or even a compromise of neurological structures then a surgical intervention is indicated.…”

Section: Discussionmentioning

confidence: 99%

Monostotic fibrous dysplasia of the spine: report of a case involving a cervical vertebra

Proschek

Orler

Stauffer

et al. 2006

Arch Orthop Trauma Surg

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Monostotic Wbrous dysplasia of the spine is a rare entity. Only 26 cases, of which 11 were located in the cervical spine, are to be found in the literature. We report a 56-year-old male patient with cervicobrachialgia of half year's duration. Radiographs showed a diVuse destruction of the vertebral body and the spinous process of C 4 . A biopsy of the spinous process conWrmed histopathologically a Wbrous dysplasia. Due to minor symptoms, no surgical treatment was performed or is planned unless in case of increasing pain, an acute instability or neurological symptoms.

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“…Spinal involvement is rare with the monostotic disease, but has been reported to involve the cervical, thoracic, or lumbar spine [2][3][4]. Polyostotic fibrous dysplasia more commonly involves the spine, with an incidence ranging from 7% in the cervical spine [5] to 14% in the lumbar spine [6]. In the majority of cases these lesions are asymptomatic and require no treatment [2].…”

Section: Discussionmentioning

confidence: 99%