Monostotic fibrous dysplasia of the spine: report of a case involving a cervical vertebra

Proschek, D.; Orler, René; Stauffer, Edouard; Heini, Paul F.

doi:10.1007/s00402-006-0231-5

Cited by 19 publications

(23 citation statements)

References 19 publications

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“…FD, a benign affliction of the skeleton, consists of one or more foci that are composed of cellular fibrous tissue containing irregular bone trabeculae that lead to distortion and structural weakness of the bone [7]. Involvement of the spinal column in FD is uncommon, Bodies…”

Section: Discussionmentioning

confidence: 99%

“…Four patients with polyostotic FD had involvement of the cervical spine. In spinal FD, the vertebral body is affected most frequently, owing to the relatively large amount of cancellous bone [7]. Because of the close relationship to the vertebral body, involvement of the pedicles has been described in nearly all cases in which the vertebral bodies are affected [12,15,[17][18][19].…”

Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 99%

“…Ultimately, the affected bone may undergo expansile remodelling secondary to the enlarging mass of fibro-osseous tissue [6]. Cellular fibrous tissue containing irregular bone trabeculae has been demonstrated as an alteration of the normal biomechanical properties of bone [7,21]. It results in distortion and structural weakness of the bone and abnormal remodelling of the affected bone.…”

Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 99%

“…Although patients afflicted with FD may present at any age, they are typically young and in the first and second decades of life [6]. After puberty, dysplastic areas rarely expand [7]. In general, the progression of the skeletal lesions tends to be exhausted once patients have reached adult age [7].…”

mentioning

confidence: 99%

“…After puberty, dysplastic areas rarely expand [7]. In general, the progression of the skeletal lesions tends to be exhausted once patients have reached adult age [7]. The diagnosis of FD is difficult in adult patients because cases in older patients, especially those involving the spine, are rare.…”

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confidence: 99%

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CT and MRI of fibrous dysplasia of the spine

Park¹,

Lee²,

Choi³

et al. 2012

BJR

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Objectives: The purpose of this study was to present the CT and MRI findings of patients with fibrous dysplasia (FD) of the spine. Methods: Among the patients with pathologically proven skeletal FD, 12 (8 males and 4 females; mean age, 43 years) who were evaluated with either spine CT or MRI were included. The number and location of the involved vertebral segments, the presence of lytic lesions, ground-glass opacity (GGO), an expansile nature, cortical disruption, a sclerotic rim, a decrease in body height and contour deformity were examined on CT scans (n512), while signal intensity, enhancement patterns and the presence of a dark signal rim on the lesion were examined using MRI (n59). Results: Nine patients had polyostotic FD, including one with an isolated spinal localisation, while three had monostotic FD. An expansile nature (n53) and osteolytic lesions with GGO (n53) were seen. On CT images, GGO was noted in all patients. An expansile nature (n511) and presence of lytic lesions (n511) were noted. A decrease in body height (n59) and sclerotic rim formation (n59) were indicated. Contour deformities were visible in six patients. The MRI findings were non-specific. Dark signal rims were visible on MRI in seven patients. Conclusion: Typical imaging findings of extraspinal FD were noted on spine CT scans. These characteristic CT imaging findings of spinal FD may be helpful in differentiating FD from other common spine diseases. Fibrous dysplasia (FD) is a developmental defect of osteoblastic differentiation and bone maturation of unknown origin [1]. FD may affect the skeleton either in isolation (monostotic FD, rate, 70-80%; and polyostotic FD, rate, 20-30%) or in variable combination with endocrine and cutaneous abnormalities (McCune-Albright syndrome) [2][3][4][5]. Although patients afflicted with FD may present at any age, they are typically young and in the first and second decades of life [6]. After puberty, dysplastic areas rarely expand [7]. In general, the progression of the skeletal lesions tends to be exhausted once patients have reached adult age [7]. The diagnosis of FD is difficult in adult patients because cases in older patients, especially those involving the spine, are rare.FD represents approximately 7% of all benign tumourlike bone lesions [8]. However, the spine is affected in only 2.5% of cases, and FD of the spine is very rarely observed without there being disease elsewhere in the body [9]. Spinal involvement occurs mostly in the polyostotic form of FD; it is unusual for it to occur in the monostotic form [9,10]. When present in the elderly with multiple vertebral lesions, a biopsy may be indicated because metastatic disease or multiple myeloma may simulate a benign non-aggressive process. Therefore, active diagnosis and radiological familiarity of spinal FD are thought to be essential for preventing unnecessary examinations or procedures.The purpose of this study was to present the CT and MRI findings of spinal FD, which is rare, and to assess the efficacy of CT in the diagnosis of FD. Me...

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Section: Discussionmentioning

confidence: 99%

Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 99%

Section: S K Park I S Lee J-y Choi Et Almentioning

confidence: 99%

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confidence: 99%

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CT and MRI of fibrous dysplasia of the spine

Park¹,

Lee²,

Choi³

et al. 2012

BJR

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Kyphotic deformity of the lumbar spine due to a monostotic fibrous dysplasia of the second lumbar vertebra: a case report and its surgical management

et al. 2020

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Monostotic fibrous dysplasia (MFD) of the lumbar spine represents an exceedingly rare lesion. A 26-year-old patient presented with a progressive osteolytic lesion of the vertebral body L2 and the diagnosis of MFD. A minimally invasive left-sided eXtreme Lateral Interbody Fusion (XLIF) approach with resection of the vertebral body L2 with placement of a mesh cage was performed. No complications were observed perioperatively and the symptoms rapidly improved. Minimally invasive piecemeal resection with a combined dorsolateral approach showed a favorable clinical and radiological outcome and seems to be a safe and reliable technique for MFD.

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A 33-year-old Man With Low Back Pain

Zhang

Hess

Nielsen

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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A 33-year-old man was evaluated in the clinic for a 9-month history of low back pain. The pain was dull and low grade, worse with activity, occasionally waking him at night. He had no history of antecedent trauma. He had no radiation of pain, focal neurologic symptoms, balance difficulties, or difficulties with fine motor tasks. He had tried aspirin with variable relief, and acupuncture and chiropractic care with no significant improvement. He had no medical conditions, never had spine surgery, and never smoked. He exercised daily doing weight lifting and martial arts, with which his back pain interfered.On physical examination, the patient was generally healthy and appeared well. He had midline tenderness to palpation in his midlumbar spine. The patient had normal strength and ROM, and sensation was intact to light touch throughout. He had normal deep tendon reflexes and no long tract signs. He had normal gait and station.AP and lateral plain films (Fig. 1) of the lumbar spine were obtained initially, followed by CT (Fig. 2) and MRI (Fig. 3); the latter tests were ordered owing to the findings we observed on the plain radiographs.

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Monostotic fibrous dysplasia of the spine: report of a case involving a cervical vertebra

Cited by 19 publications

References 19 publications

CT and MRI of fibrous dysplasia of the spine

CT and MRI of fibrous dysplasia of the spine

Kyphotic deformity of the lumbar spine due to a monostotic fibrous dysplasia of the second lumbar vertebra: a case report and its surgical management

A 33-year-old Man With Low Back Pain

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