Fibrous Dysplasia of Mandibular Bone in a Dog

Fitzgerald, Wayne; Slocombe, R. F.; Caiafa, Anthony

doi:10.1177/089875640201900203

Cited by 6 publications

(9 citation statements)

References 3 publications

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“…37,40 FD has been reported in a variety of veterinary species. 6,17,25,29,31,54,55 In the present study, FD was diagnosed in patients between 10 and 11 years old. Radiographically, FD can vary from a radiolucent lesion to a uniformly mineralized mass.…”

Section: Discussionmentioning

confidence: 98%

Benign and Malignant Proliferative Fibro-osseous and Osseous Lesions of the Oral Cavity of Dogs

et al. 2015

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Ossifying fibroma (OF) and fibrous dysplasia (FD) are benign, intraosseous, proliferative fibro-osseous lesions (PFOLs) characterized by replacement of normal bone by a fibrous matrix with various degrees of mineralization and ossification. Osteomas are benign tumors composed of mature, well-differentiated bone. Clinical, imaging, and histologic features of 15 initially diagnosed benign PFOLs and osteomas of the canine oral cavity were evaluated. Final diagnoses after reevaluation were as follows: OF (3 cases), FD (4 cases), low-grade osteosarcoma (LG-OSA) (3 cases), and osteoma (5 cases). Histology alone often did not result in a definitive diagnosis for PFOL. OF appeared as a well-circumscribed, radiopaque mass with some degree of bone lysis on imaging. Most lesions of FD showed soft tissue opacity with bone lysis and ill-defined margins. Low-grade OSA appeared as a lytic lesion with a mixed opacity and ill-defined margins. Osteomas were characterized by a mineralized, expansile, well-circumscribed lesion. Although histologic features of PFOLs were typically bland, the lesions diagnosed as LG-OSA had some features of malignancy (eg, bone invasion or a higher mitotic index). Treatment varied widely. Of the 10 dogs with benign PFOL or osteoma with known outcome (10/12), 9 showed either complete response (6/10) or stable disease (3/10) after treatment. Of the 2 dogs with LG-OSA with known outcome, 1 showed complete response after curative intent surgery, but 1 patient had recurrence after partial maxillectomy. Definitive diagnosis of mandibular/maxillary PFOL is challenging via histopathologic examination alone, and accurate diagnosis is best achieved through assimilation of clinical, imaging, and histopathologic features.

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Section: Discussionmentioning

confidence: 98%

Benign and Malignant Proliferative Fibro-osseous and Osseous Lesions of the Oral Cavity of Dogs

et al. 2015

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“…6 The gold standard of treatment for PFOLs, osteomas and LG-OSAs involving the jaw in dogs is removal with up to 2 cm bone margins to maximise the likelihood of clean surgical margins and so minimise recurrence. 10,12,13,18 In cases where complete excision is not possible, radiation therapy may be considered, but development of secondary malignancies has been reported in previously irradiated cases of human FD. Wide surgical resection was not considered in the present case owing to the lysis of the cribiform plate and the lower morbidity associated with an incomplete resection.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Low-grade osteosarcomas (LG-OSAs) should also be included in the differential diagnosis of mandibular PFOLs as they share histological resemblances with these benign lesions. 9 Reports in small animals are uncommon, [10][11][12][13][14][15][16] and some of the forms described in people have not been reported in veterinary medicine. Reaching a definitive diagnosis of a fibro-osseous lesion poses a challenge for human and veterinary pathologists owing to the similarity of the different subtypes (OF, FD, COD, LG-OSA) in their microscopic appearance.…”

Section: Introductionmentioning

confidence: 99%

Intranasal proliferative fibro-osseous dysplasia in a domestic longhair cat

D'Aout

Renfrew

Dobromylskyj³

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 13-year-old female domestic longhair cat was presented for further investigation of chronic sneezing combined with a right-sided nasal discharge. A CT scan of the head revealed a locally invasive, aggressive right nasal mass radiographically consistent with a malignant neoplastic process. Histopathology on rhinoscopically guided biopsies revealed an unusual pathology consistent with fibro-osseous hyperplasia/dysplasia. Surgical treatment via a ventral rhinotomy and curettage was performed, and the diagnosis confirmed by repeat histopathology. The cat’s clinical signs significantly improved postoperatively. Relevance and novel information This case report describes an unusual feline nasal pathology. To our knowledge, there are no previous reports of a non-neoplastic, non-inflammatory expansile feline nasal tumour. Also described are the CT and histological appearance of the mass, and the difficulties encountered obtaining the definitive diagnosis. Information regarding the prognosis following surgical removal of proliferative fibro-osseous lesions in cats is poor, especially from the nasal cavity where clean margins may well be impossible to obtain. In this case, surgical resection improved clinical signs and the cat remains well at 15 months post-procedure.

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“…These lesions represent benign or low-grade malignancy (Dennis et al 2010). When expansile osteolytic lesions are observed, giant cell tumour (Berg et al 1990), enchondroma or enchondromatosis (Huff and Brodey 1964), osteochondroma or multiple cartilaginous exostoses (Green et al 1999), benign bone cyst (Biery et al 1976), aneurysmal bone cyst (Dowdle et al 2003), fibrous dysplasia (Fitzgerald et al 2002), and bone abscess (Biery et al 1976) are typically considered in differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Atypical radiographic features of multiple myeloma in a dog: a case report

Sung¹,

Lim²,

Oh³

et al. 2017

Vet. Med. - Czech

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ABSTRACT:A 12-year-old castrated male miniature pinscher dog presented with right forelimb lameness. An expansile osteolytic lesion of the right humerus was conspicuous on right forelimb radiographs. Thoracic and abdominal radiographs showed multiple lytic bone lesions on the right scapula, ribs, vertebrae, femurs and pelvis. Additionally, an expansile osteolytic lesion was observed in two thoracic vertebrae and two ribs. Many plasma cells were identified on fine-needle aspiration of the right humerus expansile osteolytic lesion, and monoclonal gammopathy consistent with multiple myeloma was confirmed on serum protein electrophoresis. The expansile osteolytic lesion, an extraordinary radiographic feature of multiple myeloma in dogs, should be considered as a possible radiographic finding of multiple myeloma.

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Fibrous Dysplasia of Mandibular Bone in a Dog

Cited by 6 publications

References 3 publications

Benign and Malignant Proliferative Fibro-osseous and Osseous Lesions of the Oral Cavity of Dogs

Benign and Malignant Proliferative Fibro-osseous and Osseous Lesions of the Oral Cavity of Dogs

Intranasal proliferative fibro-osseous dysplasia in a domestic longhair cat

Atypical radiographic features of multiple myeloma in a dog: a case report

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