Fibroblast growth factor 18 regulates steroidogenesis in fetal bovine ovarian tissue in vitro

Silva, Rúbia Bueno da; Yang, Ming; Caixeta, Ester Siqueira; Castilho, A. C. S.; Amorim, Renée Laufer; Price, Christopher A.; Fortune, J.E.; Buratini, J.

doi:10.1002/mrd.23091

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…A recent study by da Silva (69) demonstrates that fibroblast growth factor 18 (FGF18) produced by ovigerous cords in the fetal bovine ovary may inhibit production of estrogen during this early development period. FGF18 expression increases at the time when fetal ovarian estrogen and progesterone are declining, which occurs around the time of follicle assembly.…”

Section: The Steroidogenesis Timeline and Pathways In Granulosa And Tmentioning

confidence: 99%

“…FGF18 expression increases at the time when fetal ovarian estrogen and progesterone are declining, which occurs around the time of follicle assembly. Interestingly, treatment of cultures bovine fetal ovarian explants with FGF18 inhibits production of CYP19A1 and CYP11A1, causing reductions in secretion of both estrogen and progesterone in vitro (69). Thus, steroid production occurs early in the ovary from the ovigerous cords, which later become oogonial clusters or cysts; and FGF18 may be a paracrine growth factor that allows for both follicle development and granulosa/theca cell differentiation.…”

Section: The Steroidogenesis Timeline and Pathways In Granulosa And Tmentioning

confidence: 99%

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Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function

et al. 2019

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Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed. The corpus luteum formed from the luteinized somatic follicular cells following ovulation, vasculature cells, and immune cells is critical for progesterone production and maintenance of pregnancy. Follicular theca cells differentiate into small luteal cells (SLCs) that produce progesterone in response to luteinizing hormone (LH), and granulosa cells luteinize to become large luteal cells (LLCs) that have a high rate of basal production of progesterone. The formation and function of the corpus luteum rely on the appropriate proliferation and differentiation of both granulosa and theca cells. If any aspect of granulosa or theca cell luteinization is perturbed, then the resulting luteal cell populations (SLC, LLC, vascular, and immune cells) may be reduced and compromise progesterone production. Thus, many factors that affect the differentiation/lineage of the somatic cells and their gene expression profiles can alter the ability of a corpus luteum to produce the progesterone critical for pregnancy. Our laboratory has identified genes that are enriched in somatic follicular cells and luteal cells through gene expression microarray. This work was the first to compare the gene expression profiles of the four somatic cell types involved in the follicle-to-luteal transition and to support previous immunofluorescence data indicating theca cells differentiate into SLCs while granulosa cells become LLCs. Using these data and incorporating knowledge about the ways in which luteinization can go awry, we can extrapolate the impact that alterations in the theca and granulosa cell gene expression profiles and lineages could have on the formation and function of the corpus luteum. While interactions with other cell types such as vascular and immune cells are critical for appropriate corpus luteum function, we are restricting this review to focus on granulosa, theca, and luteal cells and how perturbations such as androgen excess and inflammation may affect their function and fertility.

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Section: The Steroidogenesis Timeline and Pathways In Granulosa And Tmentioning

confidence: 99%

Section: The Steroidogenesis Timeline and Pathways In Granulosa And Tmentioning

confidence: 99%

Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function

et al. 2019

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“…And LPAR2 was found to be abundantly expressed in the oviduct of cattle, suggesting that the oviduct is an important target of LPA [57]. Fibroblast growth factor 18 (FGF18) inhibits the secretion of estradiol and progesterone, and is a candidate factor that regulated the steroidogenesis during ovarian development [58]. Moreover, FGF18 is likely to cause granulosa cell apoptosis, thereby affecting follicular atresia [59,60].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Profile of Key CircRNAs and MiRNAs in Oviduct that Affect Sheep Reproduction

Li¹,

He²,

Zhang³

et al. 2020

Preprint

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Background: CircRNA and miRNA, as classes of non-coding RNA, have been found to play pivotal roles in sheep reproduction. There are many reports of circRNA and miRNA in ovary and uterus, but few in oviduct. In this study, RNA-Seq was performed to analyze the expression profile of circRNA and miRNA in oviduct between follicular phase and luteal phase in FecBBB (MM) and FecB++ (WW) sheep.Results: The result showed that 15 circRNAs were found differentially expressed between the follicular phase and luteal phase of FecBBB genotype (MF VS. ML), no circRNAs were found differentially expressed between the follicular phase and luteal phase of FecB++ genotype (WF VS. WL). 9 and 1 differentially expressed miRNAs were identified in MF VS. ML, and WF VS. WL, respectively. GO and KEGG analysis showed that the host genes of circRNAs in MF VS. ML were mainly involved in the Rap1 signaling pathway and PI3K-Akt signaling pathway. GO and KEGG analysis of miRNAs showed that the predicted target genes were mainly involved in the Insulin secretion and Rap1 signaling pathway in MF VS. ML. In WF VS. WL, the result showed that the predicted target genes were mainly involved in the TGF-β signaling pathway, Insulin secretion and Rap1 signaling pathway. In 3 comparison groups, GO and KEGG analysis indicated that a number of host genes and target genes (XPR1, LPAR3, SLC7A11, RAB3A, PLCB3, CREB3L4, LPAR1, LPAR2, FGF18, TACR3, BMP6, SMAD4, SKP1) were found to influence sheep reproduction. Conclusion: The results of the study will help to elucidate the regulatory mechanisms of circRNAs and miRNAs in sheep reproduction. And, this study will enrich the sheep circRNA and miRNA databases, which provide a basis for further research on sheep reproduction.

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“…The actions of FGF family members begin in the initial steps of reproduction mechanisms, therefore, FGF-10 expression has been detected in theca cells and ovarian stromal cells in humans [ 88 ], and FGF-2 and FGF-10 have been shown to increase the survival and proliferation of cumulus cells, increasing blastocyst development rates in bovine, sheep, and yak, in in vitro cultures [ 89 , 90 , 91 , 92 ]. Another family member, FGF-18, seems to regulate steroidogenesis in the fetal ovary [ 93 ]. In the early development of bovine embryos, FGF-2 regulates the expression of genes related to the development and proliferation of ICM, such as Nanog and GATA6 [ 94 ].…”

Section: Growth Factors and Early Developmentmentioning

confidence: 99%

Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach

Llobat

2021

Veterinary Sciences

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The regulation of early events in mammalian embryonic development is a complex process. In the early stages, pluripotency, cellular differentiation, and growth should occur at specific times and these events are regulated by different genes that are expressed at specific times and locations. The genes related to pluripotency and cellular differentiation, and growth factors that determine successful embryonic development are different (or differentially expressed) among mammalian species. Some genes are fundamental for controlling pluripotency in some species but less fundamental in others, for example, Oct4 is particularly relevant in bovine early embryonic development, whereas Oct4 inhibition does not affect ovine early embryonic development. In addition, some mechanisms that regulate cellular differentiation do not seem to be clear or evolutionarily conserved. After cellular differentiation, growth factors are relevant in early development, and their effects also differ among species, for example, insulin-like growth factor improves the blastocyst development rate in some species but does not have the same effect in mice. Some growth factors influence genes related to pluripotency, and therefore, their role in early embryo development is not limited to cell growth but could also involve the earliest stages of development. In this review, we summarize the differences among mammalian species regarding the regulation of pluripotency, cellular differentiation, and growth factors in the early stages of embryonic development.

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Fibroblast growth factor 18 regulates steroidogenesis in fetal bovine ovarian tissue in vitro

Cited by 8 publications

References 34 publications

Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function

Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function

Transcriptome Profile of Key CircRNAs and MiRNAs in Oviduct that Affect Sheep Reproduction

Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach

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