Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum

Abstract

Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) –glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) – glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.

Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review

“…Long-chain omega-3 and -6 fatty acids such as eicosapentaenoicacid (EPA, 20:5n-3), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3) are particularly rich in some Sargassum species (Terasaki et al, 2009;van Ginneken et al, 2011). Glycolipids in Sargassum includes glucosylglycerols, galactosylglycerols and sulphonoglycolipids (Son et Wu et al, 2009). Some glucosyldiacylglycerols in S. fulvellum showed fibrinolytic activity in the reaction system of single chain urokinasetype plasminogen activator and plasminogen (Wu et al, 2009).…”

“…Glycolipids in Sargassum includes glucosylglycerols, galactosylglycerols and sulphonoglycolipids (Son et Wu et al, 2009). Some glucosyldiacylglycerols in S. fulvellum showed fibrinolytic activity in the reaction system of single chain urokinasetype plasminogen activator and plasminogen (Wu et al, 2009). To date, the understanding of the pharmacological activity of the glycolipids in Sargassum is limited.…”

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health

“…Other bioactive substances found in Sargassum sp. were monogalactosyldiacylglycerols that showed antifungal [23] and fibrinolytic activities [24]. Sulfoglycerolipid demonstrated antibacterial [25] and antiviral activities [26].…”

Sargassum fulvellumProtects HaCaT Cells and BALB/c Mice from UVB-Induced Proinflammatory Responses

“…Polysaccharide fraction obtained by fractional precipitation with ethanol from hot water extract of SF exhibited antitumor activity [12]. In addition, two fibrinolytic compounds were isolated, purified, and characterized from SF [13]. …”