Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review

Лю, Лэй; Heinrich, Michael; Myers, Stephen P; Dworjanyn, Symon A.

doi:10.1016/j.jep.2012.05.046

Cited by 326 publications

(220 citation statements)

References 151 publications

(101 reference statements)

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“…However, such traditional knowledge has not gained much importance in drug discovery because of a lack of systematic studies and scientific evidence. Recently, several studies have been carried out on Sargassum species owing to their diverse pharmacological properties and structurally novel bioactive compounds (Liu et al 2012). Although various phytochemical and pharmacological studies have been conducted on Sargassum species, to the authors' knowledge the antidiabetic activity of S. polycystum and S. wightii has not been reported previously.…”

Section: Discussionmentioning

confidence: 98%

“…The preliminary phytochemical screening revealed the presence of major bioactive compounds such as alkaloids, phenols, flavanoids, glycosides, lipids, proteins and carbohydrates. These bioactive compounds have been shown to possess a wide range of pharmacological properties, including antidiabetic and antioxidant activity (Liu et al 2012). Therefore, the seaweed extracts were further analysed for antidiabetic and antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

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Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Unnikrishnan

Suthindhiran

Jayasri

2015

Frontiers in Life Science

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Two edible seaweeds, Sargassum polycystum and Sargassum wightii, were investigated for their antidiabetic potential using in vitro enzyme inhibitory assays. Among the various extracts, petroleum ether and ethyl acetate extracts of S. wightii showed significant inhibitory effects against α-amylase (IC 50 378.3 μg/ml) and α-glucosidase (IC 50 314.8 μg/ml). Methanol extract of S. wightii showed the highest inhibition against dipeptidyl peptidase-IV (DPP-IV) (IC 50 38.27 μg/ml) and moderate antioxidant activity was observed in acetone extract of S. wightii (44%). Similarly, ethyl acetate extract of S. polycystum showed the highest inhibition against α-amylase (IC 50 438.5 μg/ml) and methanol extract of S. polycystum showed maximum inhibition against α-glucosidase (IC 50 289.7 μg/ml) and DPP-IV (36.94 μg/ml). The antioxidant activity was poor (22%). The extracts were investigated for in vitro cytotoxicity, DNA fragmentation in macrophages and haemolytic activity against erythrocytes, but no notable toxicity was observed with any of the tested extracts. Gas chromatography-mass spectrometry revealed the presence of the antidiabetic compound fucosterol and other major bioactive compounds, giving an insight into the antidiabetic and antioxidant properties of these algae. This study reveals the possible mechanisms of antidiabetic action in vitro, and these two seaweeds may also have an antidiabetic action in vivo.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Unnikrishnan

Suthindhiran

Jayasri

2015

Frontiers in Life Science

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“…Numerous studies are being carried out globally in order to check the bioactivities, such as antibacterial, antiviral, antineoplastic, anti-inflammatory, cytotoxic and antimitotic activities of marine algae or to isolate compounds for different purposes such as pharmaceutical, cosmetics and food preservatives, antifouling coatings, etc. (Fenical and Paul 1984;Hodgson 1984;Scheuer 1990;Ballesteros et al 1992;Sastry and Rao 1994;Armstrong et al 2000;Gonzalez del Val et al 2001;Bhosale et al 2002;Ozdemir et al 2006;Salvador et al 2007;Tierney et al 2010;Wada et al 2011;Liu et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antioxidant activities with acute toxicity, cytotoxicity and mutagenicity of Cystoseira compressa (Esper) Gerloff & Nizamuddin from the coast of Urla (Izmir, Turkey)

et al. 2013

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The aim of the study was to evaluate the biological activities with toxic properties of the methanol, hexane, and chloroform extracts of Cystoseira compressa (Esper) Gerloff & Nizamuddin from the Coast of Urla in the Aegean Sea. The extracts of C. compressa were tested for their antimicrobial and antioxidant activities in this study. Cytotoxic and mutagenic potentials of the extracts were also evaluated using cell culture and mutagenicity assays. Hexane extract was found to have higher total flavonoid and phenolic contents than the other extracts and exerted higher antioxidant activity than other extracts. All extracts exhibited moderate antimicrobial activity against tested microorganisms (minimum inhibitory concentration ranges are 32-256 lg/mL). The results indicated that the extracts had no significant cytotoxic activity against human hepatocellular carcinoma Hep 3B cell line in all treated concentrations (5-50 lg/mL) and did not show mutagenicity in the Ames test. Lethality was not observed among mice treated with oral doses of the extracts. In conclusion, results of investigations indicate that brown alga C. compressa is a natural source of antioxidant. It has moderate antimicrobial activities with no toxicity.

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“…biofuel [7], bioenergy [8], food, supplement [9], pharmaceutical [10] and medical [11,12]. Study of algae bioactive compound has grown in line with the isolation, purification, and characterization of the natural product.…”

Section: Introductionmentioning

confidence: 99%

Screening of proteins based on macro-algae from West Java coast in Indonesian marine as a potential anti-aging agent

Putri

Dewi

Handayani³

et al. 2018

AIP Conference Proceedings

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Abstract. Algae has been known as one of the potential marine bio-resources that have been used in many fields such as bio-energy, food, pharmaceutical and medical applications. Study of macro-algae or seaweed for medicine application, in particular, highlights to empower their ingredients as a promising antioxidant like anti-aging agent due to their diversity in biological activity. The tropical climate of Indonesia with the highest marine biodiversity puts this country an auspicious source of numerous alga species as a novel antioxidant source. A Sample of 29 species of macroalgae has been collected from Coast of Pari Island as a part of Seribu Islands, Indonesia. Screening and extracting of aqueous tropical marine alga protein as a potential source for an antioxidant agent has been done by using 2,2-diphenyl-1-picrylhydrazyl scavenging method, and protein contents have been determined by Lowry method. Sample number 26 of the phylum Rhodophyta have 9.00±0.03 % protein content, which is potential for nutritional food in form of nutraceutical. That sample demonstrated the maximum DPPH scavenging activity 79.27±1.81 %. Moreover, crude extract from another species from phylum Rhodophyta had the very lower IC50 (3.4333±0.29 mg/ml) followed by Chlorophyta species (7.1069±1.78 mg/ml). In general, this study found that algae from phylum Rhodophyta possess a high content of protein, high activity towards free radical. Nevertheless, algae acquire the lowest IC50 value not only dominated by Rhodophyta but also from phylum Chlorophyta. The conclusion of this study leads to empowering high antioxidant activity algae as an anti-aging agent, which can be used in pharmaceutical applications. Therefore, the next study should be concerned on the properties of the algae which has been known to be suitable for pharmaceutical fields.

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Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review

Cited by 326 publications

References 151 publications

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Antimicrobial and antioxidant activities with acute toxicity, cytotoxicity and mutagenicity of Cystoseira compressa (Esper) Gerloff & Nizamuddin from the coast of Urla (Izmir, Turkey)

Screening of proteins based on macro-algae from West Java coast in Indonesian marine as a potential anti-aging agent

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