Fibrin nanoparticles as Possible vehicles for drug delivery

Vedakumari, Weslen S.; Prabu, P.; Babu, Saravana; Sastry, T. P.

doi:10.1016/j.bbagen.2013.04.032

Cited by 52 publications

(18 citation statements)

References 45 publications

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“…190 These nano-fibrin scaffolds were also used to enhance angiogenesis in chitin/poly (butylene succinate)/bioactive glass 191 and chitin/calcium sulfate gels. 192 Vedakumari et al 193 developed a wet precipitation method for synthesizing FNPs. In this technique, first, a crude form of fibrin was isolated from bovine blood by stirring the blood with a glass rod.…”

Section: Application Of Nanotechnology In Fibrin-based Bone Tissue Enmentioning

confidence: 99%

“…Biocompatibility of the FNPs was demonstrated by in vitro and in vivo analyses. 193 The authors, in their next study, prepared magnetic FNPs (MAG-FNPs). To this, they incinerated red blood cells of defibrinated blood and dissolved the residue in 5 N HCl to obtain an iron solution which was added dropwise to a fibrin/NaOH solution as mentioned earlier.…”

Section: Application Of Nanotechnology In Fibrin-based Bone Tissue Enmentioning

confidence: 99%

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A review of fibrin and fibrin composites for bone tissue engineering

Noori

Ashrafi

Vaez-Ghaemi

et al. 2017

IJN

362

256

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Tissue engineering has emerged as a new treatment approach for bone repair and regeneration seeking to address limitations associated with current therapies, such as autologous bone grafting. While many bone tissue engineering approaches have traditionally focused on synthetic materials (such as polymers or hydrogels), there has been a lot of excitement surrounding the use of natural materials due to their biologically inspired properties. Fibrin is a natural scaffold formed following tissue injury that initiates hemostasis and provides the initial matrix useful for cell adhesion, migration, proliferation, and differentiation. Fibrin has captured the interest of bone tissue engineers due to its excellent biocompatibility, controllable biodegradability, and ability to deliver cells and biomolecules. Fibrin is particularly appealing because its precursors, fibrinogen, and thrombin, which can be derived from the patient’s own blood, enable the fabrication of completely autologous scaffolds. In this article, we highlight the unique properties of fibrin as a scaffolding material to treat bone defects. Moreover, we emphasize its role in bone tissue engineering nanocomposites where approaches further emulate the natural nanostructured features of bone when using fibrin and other nanomaterials. We also review the preparation methods of fibrin glue and then discuss a wide range of fibrin applications in bone tissue engineering. These include the delivery of cells and/or biomolecules to a defect site, distributing cells, and/or growth factors throughout other pre-formed scaffolds and enhancing the physical as well as biological properties of other biomaterials. Thoughts on the future direction of fibrin research for bone tissue engineering are also presented. In the future, the development of fibrin precursors as recombinant proteins will solve problems associated with using multiple or single-donor fibrin glue, and the combination of nanomaterials that allow for the incorporation of biomolecules with fibrin will significantly improve the efficacy of fibrin for numerous bone tissue engineering applications.

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Section: Application Of Nanotechnology In Fibrin-based Bone Tissue Enmentioning

confidence: 99%

Section: Application Of Nanotechnology In Fibrin-based Bone Tissue Enmentioning

confidence: 99%

A review of fibrin and fibrin composites for bone tissue engineering

Noori

Ashrafi

Vaez-Ghaemi

et al. 2017

IJN

362

256

View full text Add to dashboard Cite

show abstract

“…Significant upregulation of both CD4 + /CD8 + T-cells and CD80 + /CD86 + on the APCs suggested differentiate and in case of B cells, in stimulation of antibody production. Vedakumari et al[134] prepared FNPs using wet precipitation procedure without using factor XIII or other crosslinking reagents and evaluated their toxicity among others on the immune system. The FNPs did not significantly activate the classical, lectinor the alternative pathway of complement.…”

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confidence: 99%

Fibrin matrices: The versatile therapeutic delivery systems

Ahmad

Fatima

Hoque

et al. 2015

International Journal of Biological Macromolecules

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“…Upon increasing the concentration of CQDs from 50 μg/mL to 250 μg/mL, the cell viability (%) was not affected significantly that retained the cell viability > 90 % in both cell lines as evidenced from the microscopical images. Previous report shows that the QDs which retain the cell viability >80 % are considered as safe materials for biological applications . Here, the synthesized CQDs show better biocompatible nature, and it can be used for various biological applications.…”

Section: Resultsmentioning

confidence: 84%

Sweet Corn (Zea mays L. var. rugosa) Derived Fluorescent Carbon Quantum Dots for Selective Detection of Hydrogen Sulfide and Bioimaging Applications

Rajendran

Kasthuri³

et al. 2019

ChemistrySelect

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We report a green, simple, and facile fluorometric method for the detection of hydrogen sulfide (S 2À ) using bluish green carbon quantum dots (CQDs) derived from sweet corn (Zea mays L. var. rugosa) as carbon source. The optical properties of the CQDs were studied using UV-visible, PL spectra and lifetime measurements. High-resolution transmission electron microscopy (HR-TEM), atomic force microscope (AFM) and dynamic light scattering (DLS) were used for morphological studies. Xray diffraction (XRD) technique was used for phase analysis. Zeta potential, Fourier transform infrared (FT-IR), Raman and Xray photoelectron spectroscopy (XPS) were used to measure the charge and composition of QDs. The prepared CQDs having size less than 2.4 nm with bluish green emission at ∼ 470 nm and showed excellent stability for more than 6 months in aqueous medium. The synthesized CQDs showed highly sensitive and selective detection of sulfide ions (S 2À ) in aqueous medium over other toxic metal ions and inorganic salts, and the detection limit was 8 nM in the linear range from 5 to 100 nM. The synthesized CQDs had excellent hemocompatibility as evidenced from the hemolytic assay (2.86 %) and ESR estimation (7.5 mm/h) on human RBCs. The cell viability of CQDs was evaluated on Vero and A549 cell line by MTT assay, which produced more than 90 % of cell viability in both cell lines at 250 μg/mL concentration. Owing to their biocompatible nature, the synthesized CQDs were used as a fluorescent probe for in vitro bioimaging applications.

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Fibrin nanoparticles as Possible vehicles for drug delivery

Cited by 52 publications

References 45 publications

A review of fibrin and fibrin composites for bone tissue engineering

A review of fibrin and fibrin composites for bone tissue engineering

Fibrin matrices: The versatile therapeutic delivery systems

Sweet Corn (Zea mays L. var. rugosa) Derived Fluorescent Carbon Quantum Dots for Selective Detection of Hydrogen Sulfide and Bioimaging Applications

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