Ahstract-We report on the development of a high-resolution « GHz at 1.0 THz), broadly-tunable (-0.5 -3.0 THz) fiber MOPA-based terahertz spectrometer system. The flexibility and performance of this system will be demonstrated with gaseous (water vapor) and aqueous (water and solvated protein) samples with a view towards selectively and non-destructively probing functionally significant large-scale protein motions.
\. INTRODUCTION AND BACKGROUNDA narrow-bandwidth terahertz spectrometer with a tuning range limited to 0.4 THz from a central wavelength has been previously demonstrated in our group by Malinowski et al. l . In this work we demonstrate our progress towards a significantly upgraded system tunable over a range in excess of 2.0 THz (Fig.1). Since protein folding dynamics take place on the picosecond timescale, vibrational modes tend to lie in the sub-2THz frequency range 2 , 3 . Many recent studies have made extensive use of time-domain THz spectroscopy (TOS) 4 , 5 . The limited spectral resolution of the technique has generated a clear need for high-resolution THz sources, and recent development in this regard has been rapid and widespread 6 , 7 , 8 . Our THz system has a similar dual fiber master oscillator power amplifiers (MOP A) chain design producing two pulsed beams of 2 ns duration at a repetition rate of 0.5 MHz. The maximum peak power per channel is -5 kW (5 W average power). Both MOPA chains are designed to minimize spectral linewidth: one amplifier chain is based on a custom-built distributed feedback (DFB) laser operating at -1060 nm, and the other is based on a Toptica DL pro 1040 tunable external cavity laser with a tuning range of980 -1075 nm. The linewidth before amplification for both chains is of the order of 100 kHz. THz radiation is generated via difference frequency generation (OFG) in a (110) cleaved GaP crystal which is directed through a custom-built fluidic cell mounted in front of a silicon filter and pyroelectric THz detection system. Ahalf-wave plate is located between the main system lens and the GaP crystal to achieve optimum polarization orientation with respect to the crystal orientation.Both MOP A chains exhibit a flat gain response over the entire tuning range, with an optical signal-to-noise ratio (OSNR) of -30 dB (as measured at 0.1 nm resolution) which is particularly flat in the narrow range corresponding to the low frequency (0.5 -1.0 THz) region in the OFG process (Fig. 2).The estimated spectral linewidth of the MOP A output is -500MHz at 1060nm, corresponding to a-I GHz effective linewidth at 1.0 THz with a typical peak THz power of -3 m W.