FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study

Li, G.; Yin, Jingdong; Fu, Junsheng; Li, L.; Grant, Struan F.A.; Li, C.; Li, M.; Mi, Jie; Gao, Shan

doi:10.1016/j.diabet.2016.12.003

Cited by 26 publications

(27 citation statements)

References 38 publications

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“… 64 In Chinese children aged between 6 and 18 years, the opposite has been described, with deficiency – rather than resistance – being found. 67 The authors suggest that in children, FGF 21 deficiency – rather than resistance – contributes to insulin resistance and hypoadiponectinemia. Interestingly, leptin has recently been shown to increase FGF 21 levels in Wistar rats and in human-derived hepatoma HepG2 cells.…”

Section: Fibroblast Growth Factors (Fgfs)mentioning

confidence: 99%

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Tomkin¹,

Owens²

2017

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Premature atherosclerosis in diabetes accounts for much of the decreased life span. New treatments have reduced this risk considerably. This review explores the relationship among the disturbances in glucose, lipid, and bile salt metabolic pathways that occur in diabetes. In particular, excess nutrient intake and starvation have major metabolic effects, which have allowed us new insights into the disturbance that occurs in diabetes. Metabolic regulators such as the forkhead transcription factors, the farnesyl X transcription factors, and the fibroblast growth factors have become important players in our understanding of the dysregulation of metabolism in diabetes and overnutrition. The disturbed regulation of lipoprotein metabolism in both the intestine and the liver has been more clearly defined over the past few years, and the atherogenicity of the triglyceride-rich lipoproteins, and – in tandem – low levels of high-density lipoproteins, is seen now as very important. New information on the apolipoproteins that control lipoprotein lipase activity has been obtained. This is an exciting time in the battle to defeat diabetic atherosclerosis.

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Section: Fibroblast Growth Factors (Fgfs)mentioning

confidence: 99%

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Tomkin¹,

Owens²

2017

DMSO

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“…In a large cohort, Li and cols. (12) observed that lower FGF21 levels were negatively correlated with BMI and waist circumference and associated with obesity compared with normal-weight patients.…”

Section: Discussionmentioning

confidence: 88%

“…Cross-sectional studies conducted in adolescents with obesity showed controversial results regarding the associations between FGF21, BC, metabolic parameters and inflammatory profile (3,(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity

Kravchychyn

Campos

Ferreira

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: Fibroblast growth factor 21 (FGF21) is among the activators that can stimulate thermogenesis in the white adipose tissue and brown adipose tissue. People with obesity have elevated blood levels of FGF21, but also develop resistance to its action, impairing its beneficial role. Inversely, clinical treatments to weight loss has been pointed out as an important therapy for increasing and recovering sensitivity to FGF21. The aim was to analyse the effect of long-term weight loss interdisciplinary intervention on FGF21 and body composition. Subjects and methods: Eighty-six post-pubertal obese adolescents (14-19 years-old), were submitted to 20 weeks of weight loss therapy (clinical, nutritional, psychological and physical exercise support). Anthropometric measures, body composition and rest metabolic rate (RMR) by bioelectrical impedance, and serum FGF21 sample by ELISA were evaluated. The adolescents were grouped according to FGF21 individual delta variations after therapy: Higher Increase (HI); lower increase (LI); lower decrease (LD); higher decrease (HD). Results: All groups present weight loss. Only in FGF21 ≥ 76,5 pg/mL variation the free-fat-mass and rest metabolic rate were preserved and to others group these variables were significantly reduced. Conclusion: High increase in FGF21 can contribute to preservation of FFM and RMR after weight loss therapy, could have important implications for energy balance regulation. Future studies are necessary to continue determining the role of magnitude effects of FGF21 levels in obesity to improve clinical practice, especially in paediatrics population. 4Higher increase degree of FGF21 preserves the free fat mass and rest metabolic rate Arch Endocrinol Metab.

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“…Moreover, FGF21 levels correlated with clinical (adiposity, arterial hypertension) as well as biochemical (TG, HDL-C) features of MS. Despite its role in metabolism regulation, the reports on its usefulness as a biomarker for obesity and abnormalities associated with MS are conflicting [8,24,25,26]. FGF21, produced during fasting mainly in the liver, promotes gluconeogenesis, lipolysis, ketogenesis, ameliorates glucose uptake and improves insulin sensitivity [5].…”

Section: Discussionmentioning

confidence: 99%

“…It was previously shown that adult patients with obesity and metabolic diseases present reduced serum FGF19 levels with compensatory increase in FGF21 concentrations [5,7]. However, in the group of children and adolescents the relationship between obesity, metabolic disorders and mentioned factors has not been clearly described [8,9].…”

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confidence: 99%

Klotho, fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity – and their associations with metabolic parameters.

Socha-Banasiak

Michalak

Pacześ

et al. 2020

Preprint

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Background: Fibroblast growth factor 19 (FGF19), Fibroblast growth factor 21 (FGF21) and Klotho are regulators of energy homeostasis. However, in the paediatric population the relationship between obesity, metabolic disorders and mentioned factors has not been clearly investigated. We analysed serum concentrations of FGF19, FGF21 and Klotho in children and adolescents with normal body weight as well as in overweight and obese subjects – and their associations with components of metabolic syndrome and insulin resistance (IR).Methods: The cross-sectional study conducted in the group of hospitalised children and adolescents. Laboratory investigation included serum ELISA tests for FGF19, FGF21, Klotho as well as lipid profile and oral glucose tolerance test for calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. The clinical analysis included blood pressure measurement, body fat percentage estimation and assessing the prevalence of metabolic syndrome (MS) and its components. Results: The study was conducted on 174 children/adolescents aged 6-17 years divided into the following groups: with normal body weight (N=48), with obesity (N=92) and overweight subjects (N=34). Klotho levels were significantly higher in the group of subjects with obesity [median 168.6 pg/ml]) than those with overweight [131.3 pg/ml] and normal body weight [116.6 pg/ml] (p=0.0334). Median serum FGF21 level was elevated in the group of patients with MS in comparison to other subjects [136.2 pg/ml vs 82.6 pg/ml, p=0.0285]. Increased Klotho concentrations were noted in patients affected by IR compared with subjects with normal insulin sensitivity [185.3 pg/ml vs 132.6 pg/ml, p=0.0282]. Multivariable model for HOMA-IR showed FGF19 as an independent predictor for IR after adjusting for the pubertal stage and BMI Z-score.Conclusions: Klotho levels were associated with body weight status in children and adolescents. Moreover, Klotho, FGF19 and FGF21 concentrations correlated with IR status and traits of MS.

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FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study

Cited by 26 publications

References 38 publications

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity

Klotho, fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity – and their associations with metabolic parameters.

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