Fexofenadine Adsorption by Activated Charcoal Impregnated with Hydrogen Peroxide

Abstract

<jats:p>The adsorption of fexofenadine drug by activated charcoal powder impregnated with hydrogen peroxide (IAC) to improve its surface properties was investigated. The investigation also aimed to assess the effect of the repeated dose in increasing the amount of the drug adsorbed. The powder activated charcoal was impregnated with H2O2 3%. The effects of pH of the solution, concentration of the drug and time of the reaction parameters were investigated by using UV-Vis spectroscopy. The IAC was brought in contact with the drug solution in different pH (2, 4, 7 and 9), drug concentrations (30, 60, 90 and 120 µg ml-1) and time (15, 30, 45 and 60 minutes). After each experiment, a repeated dose of IAC was introduced into the solution and the adsorption process was repeated. The results showed that the amounts of the drug adsorbed were decreased with increasing the pH and increased with increasing the concentration of solution and time of contact. The adsorption capacity was enhanced to about 70% after the addition of the repeated dose. The study showed a spectrum displacement toward the blue region (blue shift) for the drug supernatant in all experiment parameters, which was almost doubled when a repeated dose was added.</jats:p>

Study of Micellar Behavior of a Tween 80 Surfactant in Aqueous Media Containing Diphenhydramine Hydrochloride

“…The low solubility properties of drugs are already decreasing their bioavailability and therapeutic activity and increasing consumption, while a surplus of doses of drug leads to side effects [1,2]. Because of that, research on drugs that have water solubility and encapsulation performance is wanted to increase drug absorption, bioavailability, and decrease drug doses [3][4][5]. Different methods have been studied to improve the drug solubility, such as the use of nanocarrier drugs in formulations, self-emulsifying formulations, and using polymers soluble in water in the formulations [6][7][8].…”

A Kinetic Study for Malachite Green Removal of Adsorption over Multiwall Carbon Nanotubes

“…Consequently, it is possible to efficiently extract dyes from contaminated aqueous solutions by adsorption processes.. Processes of dyes elimination are usually of low cost, quick to run, high recovery and simple design [5,6]. Carbon nanotubes (CNTs) appear to be a strong candidate as an adsorbent among a diverse array of adsorbents that can absorb wide range of organic contaminants from wastewater [7,8].…”