Background: Gout is the most prevalent inflammatory arthritis in the Asia-Pacific region and worldwide. This clinical practice guideline (CPG) aims to provide recommendations based on systematically obtained evidence and values and preferences tailored to the unique needs of patients with gout and hyperuricemia in Asia, |LORENZO Et aL. | INTRODUC TI ONGout is the most prevalent inflammatory arthritis in the Asia-Pacific region and worldwide. 1 Its prevalence increased steadily in various countries: 2.7% in the 1990s to 3.9% in early 2000 in the United States and from 3.4 per 1000 in 2007 to 7.6 per 1000 persons in 2015 in Korea. 2,3 The prevalence is higher in certain ethnic groups.The risk for tophi formation tends to be higher after controlling for age, gender, hypertension, diuretic use, and kidney function. 4 Varying prevalence across ethnic groups indicates that genetics affects its development and the individual's risk when exposed to environmental or dietary variables. 5,6 Despite scientific advancements, disease control of gout is suboptimal. 2,3 Clinical practice guidelines (CPG) from Western and several Asian countries have provided recommendations for the management of gout. [7][8][9] However, the need to formulate unified Asia-Pacific recommendations was recognized. This CPG aims to provide evidence-based recommendations in managing gout in its different phases: asymptomatic hyperuricemia, acute gout, intercritical gout, and chronic tophaceous or complicated gout. It covers both pharmacologic and non-pharmacologic interventions (NPI) with consideration of the unique needs of patients with gout in Asia, Australasia, and the Middle East. The target users of these guidelines are general practitioners and specialists, including rheumatologists, in different clinical settings in these regions. | G UIDELINE DE VELOPMENT ME THODSThe Steering Committee (SC) formed the guideline development working groups (GDG), formulated the guideline questions (Table 1) in PICO (population, intervention, comparator, and outcome) format, and oversaw the CPG processes (Figure 1). The Technical Working Group (TWG) appraised and summarized the evidence, applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to determine the certainty of evidence, and drafted the recommendations.The Consensus Panel (CP) was composed of 9 key stakeholders (rheumatologists, general practitioners, academicians, and a patient representative) from Australia,

This study presents, a numerical investigation of two‐dimensional turbulent nanofluids flow in different ribs tube configurations on heat transfer, friction, and thermal performance coefficients using ANSYS‐FLUENT software version‐16. Governing equations of mass, momentum, and energy have been solved by means of a finite volume method (FVM). Four types of nanoparticles namely; Al2O3, CuO, SiO2, and ZnO with volume fraction range (1%‐4%) and different size of nanoparticles (dp = 30 nm, 40 nm, 50 nm, and 60 nm) with various Reynolds number (10 000‐30 000) in a constant heat flux tube with rectangular, triangular, and trapezoidal ribs were conducted for simulation. The results exhibit that Nusselt number for all cases enhanced with Reynolds number and nanofluid volume fraction increases. Likewise, the results also reveal that SiO2 with volume fractions of 4% and diameters of nanoparticles of 30 nm in triangular ribs offered the highest Nusselt number at Reynolds number of Re = 30 000. In addition, the higher value of thermal performance factor was obtained at Reynolds number of Re = 10 000.

CFD simulation of heat transfer and friction factor characteristics in a circular tube fitted with twisted tape inserts in laminar flow and constant heat flux is conducted using FLUENT version 6.3.26. Plain and alternate axis twisted tape inserts with twist ratios (y = 2.93, 3.91, 4.89) and alternative angles (β = 30°, 60°, 90°) have been used for the simulation. The simulated results are matched with the literature correlations for a plain tube with a discrepancy of less than ±8% for Nusselt number and ±6.25% for friction factor. The results also revealed that the heat transfer in terms of the Nusselt number increased with increases of Reynolds number, alternative angles, and decreases of twist ratio. Among the various twist ratios and alternative angles, the twist ratio of y = 2.93 and alternative angle β = 90° offered a maximum heat transfer enhancement. © 2013 Wiley Periodicals, Inc. Heat Trans Asian Res, 43(4): 384–396, 2014; Published online 3 October 2013 in Wiley Online Library (http://wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21089

Numerical investigation of the heat transfer and friction factor characteristics of a circular fitted with V-cut twisted tape (VCT) insert with twist ratio (y = 2.93) and different cut depths (w = 0.5, 1, and 1.5 cm) were studied for laminar flow using CFD package (FLUENT-6.3.26). The data obtained from plain tube were verified with the literature correlation to ensure the validation of simulation results. Classical twisted tape (CTT) with different twist ratios (y = 2.93, 3.91, 4.89) were also studied for comparison. The results show that the enhancement of heat transfer rate induced by the classical and V-cut twisted tape inserts increases with the Reynolds number and decreases with twist ratio. The results also revealed that the V-cut twisted tape with twist ratio y = 2.93 and cut depth w = 0.5 cm offered higher heat transfer rate with significant increases in friction factor than other tapes. In addition the results of V-cut twist tape compared with experimental and simulated data of right-left helical tape inserts (RLT), it is found that the V-cut twist tape offered better thermal contact between the surface and the fluid which ultimately leads to a high heat transfer coefficient. Consequently, 107% of maximum heat transfer was obtained by using this configuration.

This paper reports experimental and computational fluid dynamics (CFD) modelling studies to investigate the effect of the swirl intensity on the heat transfer characteristics of conventional and swirl impingement air jets at a constant nozzle-to-plate distance ( = 2 ). The experiments were performed using classical twisted tape inserts in a nozzle jet with three twist ratios ( = 2.93, 3.91, and 4.89) and Reynolds numbers that varied from 4000 to 16000. The results indicate that the radial uniformity of Nusselt number (Nu) of swirl impingement air jets (SIJ) depended on the values of the swirl intensity and the air Reynolds number. The results also revealed that the SIJ that was fitted with an insert of = 4.89, which corresponds to the swirl number Sw = 0.671, provided much more uniform local heat transfer distribution on the surface. The CFD-predicted results help to explain the experimental measurements in terms of the turbulence intensity. Furthermore, the predicted and measured local Nusselt numbers were consistent with each other.

This paper presents the application of a mathematical model for simulation of the swirling flow in a tube induced by elliptic-cut and classical twist tape inserts. Effects of the twist ratio (y=2.93, 3.91, and 4.89) and cut depth (w=0.4, 0.8, and 1.4 cm) on heat transfer enhancement (Nu) and friction factor (f) in laminar flow are numerically investigated. The simulation is carried out using commercial CFD package (FLUENT-6.3.26) to grasp the physical behaviour of the thermal and fluid flows of a constant heat-fluxed tube fitted with elliptic-cut twist tape in the laminar flow regime for the Reynolds number ranging from 200 to 2100. The simulated results matched the literature correlations of plain tube for validation with 8% variation for Nusselt number and 10% for friction factor. The results show that the heat transfer rate and friction factor in the tube equipped with elliptic-cut twist tape (ECT) are significantly higher than those fitted with classical twist tape (CTT). Moreover the results also reveal that the Nusselt number and the friction factor in the tube with elliptic-cut twisted tape (ECT) increase with decreasing twist ratios (y) and cut depths (w).

Numerical investigation has been carried out on heat transfer and friction factor characteristics of copper-water nanofluid flow in a constant heat-fluxed tube with the existence of new configuration of vortex generator using Computational Fluid Dynamics (CFD) simulation. Two types of swirl flow generator: Classical twisted tape (CTT) and Parabolic-cut twisted tape (PCT) with a different twist ratio (y = 2.93, 3.91 and 4.89) and different cut depth (w = 0.5, 1.0 and 1.5 cm) with 2% and 4% volume concentration of CuO nanofluid were used for simulation. The effect of different parameters such as flow Reynolds number, twist ratio, cut depth and nanofluid were considered. The results show that the enhancement of heat transfer rate and the friction factor induced by the Classical (CTT) and Parabolic-cut (PCT) inserts increases with twist ratio and cut depth decreases. The results also revealed that the heat transfer enhancement increases with an increase in the volume fraction of the CuO nanoparticle. Furthermore, the twisted tape with twist ratio (y = 2.93) and cut depth w = 0.5 cm offered 10% enhancement of the average Nusselt number with significant increases in friction factor than those of Classical twisted tape.

This paper reports numerical investigations of heat transfer and friction factor characteristics in swirling flow conditions using CFD simulation. A commercial CFD package, FLUENT 6.3.26, was used in this study. 3D models for circular tube fitted with classical and quadrant-cut twisted tape (QCT) inserts with three twist ratios (y= 2.93, 3.91, and 4.89) and different cut depths (w= 0.5, 1.0, and 1.5 cm) were generated for the simulation. The data obtained from the CFD simulation were verified with the literature correlations of plain tube with the discrepancy of less than ±8% for Nusselt number and ±10% for friction factor. The results show that there was a significant increase in heat transfer coefficient and friction factor in the tube fitted with quadrant-cut twisted tape (QCT) with decreasing of twist ratio (y) and cut depth (w). Furthermore, the configuration of QCT insert with a twist ratio ofy= 2.93 and a cut depth ofw= 0.5 cm offered higher heat transfer rate and friction factor than other twist ratios.