Few characteristics of dengue's fever epidemiology in Brazil

Teixeira, Maria da Glória Lima Cruz

doi:10.1590/s0036-46652012000700002

Cited by 19 publications

(14 citation statements)

References 3 publications

(3 reference statements)

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“…After 2003–2004 (the greater declining period), the rates of dengue increased in Brazil. The specific serotypes, which circulate more intensely in the population in a specific period, combined with the immunity level for each serotype, may explain the space-temporal distribution of dengue’s incidence and the variation of the level of the disease over the time [20]. …”

Section: Discussionmentioning

confidence: 99%

Temporal and Spatial Evolution of Dengue Incidence in Brazil, 2001-2012

et al. 2016

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BackgroundIn Brazil, the incidence of dengue greatly increased in the last two decades and there are several factors impeding the control of the disease. The present study focused on describing the space-time evolution of dengue in Brazil from 2001 to 2012 and analyzing the relationship of the reported cases with socio-demographic and environmental factors.MethodsThe analytic units used in the preparation of thematic maps were municipalities. Statistical tests and multilevel regression models were used to evaluate the association between dengue incidence and the following factors: climate, diagnostic period, demographic density, percentage of people living in rural areas, Gross Domestic Product, Gini index, percentage of garbage collection and the rate of households with a sewage network.ResultsThe largest accumulation of dengue cases in Brazil was concentrated on the Atlantic coast and in the interior part of São Paulo State. The risk of dengue in subtropical and tropical climates was 1.20–11 times lower than that observed in semi-arid climates. In 2009–2010 and 2011–2012, the risks were ten and six times higher than in 2003–2004, respectively.ConclusionDengue is a common infection in the Brazilian population, with the largest accumulation of dengue cases concentrated on the Atlantic coast and in the interior area of São Paulo State. The high dengue rates observed in the Brazilian coastal region suggest that the cases imported from neighboring countries contribute to the spread of the disease in the country. Our results suggest that several socio-demographic and environmental factors resulted in the increase of dengue in the country over time. This is likely applicable to the occurrence of other arboviruses like Zika and chikungunya. To reverse the situation, Brazil must implement effective public policies that offer basic services such as garbage collection and sanitation networks as well as reduce vector populations.

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Section: Discussionmentioning

confidence: 99%

Temporal and Spatial Evolution of Dengue Incidence in Brazil, 2001-2012

et al. 2016

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“…Until 2006, and unlike dengue in Southeast Asia, this viruses was more common in adults in Brazil. In 2007, a marked shift in its age distribution had occurred, and it mostly affected children, among whom there was a higher incidence of severe cases (4) . This shift in the age distribution reversed in 2010, when dengue cases predominately occurred among those who were aged over 15 years (5) .…”

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Trends and factors associated with dengue mortality and fatality in Brazil

Paixão

Costa

Rodrigues

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…Noticeably, dengue incidence is growing in the Americas with 1.1 million cases reported in 2011, of which 20,000 cases were classified as severe dengue. Markedly, Brazil is responsible for the heaviest burden, reporting 764,032 cases in this period (23). In fact, dengue is a priority health issue in Brazil, draining an enormous amount of resources that may allow temporary and limited control of outbreaks (23).…”

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confidence: 99%

“…Markedly, Brazil is responsible for the heaviest burden, reporting 764,032 cases in this period (23). In fact, dengue is a priority health issue in Brazil, draining an enormous amount of resources that may allow temporary and limited control of outbreaks (23). Given that vector eradication seems an unreachable target (2), a great expectation is being deposited on the development of a vaccine (5).…”

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confidence: 99%

“…In the last decade, dengue nonstructural protein 1 (NS1), produced in both membrane-associated and secreted forms, has been utilized as an early marker, since it is present in serum in between 1 and 9 days after the onset of clinical signs, with a peak from 3 to 5 days (1,23,26). The amount of secreted NS1 (sNS1) in the serum of individuals infected with DENV has been shown to directly correlate with viremia and the pathogenesis of dengue infection (10,15).…”

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confidence: 99%

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Low Sensitivity of NS1 Protein Tests Evidenced during a Dengue Type 2 Virus Outbreak in Santos, Brazil, in 2010

Félix

Romano

Centrone

et al. 2012

Clin Vaccine Immunol

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In 2010, a large outbreak of dengue occurred in Santos, Brazil. The detection of the NS1 antigen was used for diagnosis in addition to the detection of IgG, IgM, and RNA. A large number of NS1 false-negative results were obtained. A total of 379 RNA-positive samples were selected for thorough evaluation. NS1 was reactive in 37.7% of cases. Most of the cases were characterized as a secondary infection by dengue 2 virus. Sequencing of NS1 positive and negative isolates did not reveal any mutation that could justify the diagnostic failure. Use of existing NS1 tests in the Brazilian population may present a low negative predictive value, and they should be used with caution, preferentially after performing a validation with samples freshly obtained during the ongoing epidemic.

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Few characteristics of dengue's fever epidemiology in Brazil

Cited by 19 publications

References 3 publications

Temporal and Spatial Evolution of Dengue Incidence in Brazil, 2001-2012

Temporal and Spatial Evolution of Dengue Incidence in Brazil, 2001-2012

Trends and factors associated with dengue mortality and fatality in Brazil

Low Sensitivity of NS1 Protein Tests Evidenced during a Dengue Type 2 Virus Outbreak in Santos, Brazil, in 2010

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