Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles

Abstract

Oxidative stress and dysfunctional mitochondria are among the earliest events in AD, triggering neurodegeneration. The use of natural antioxidants could be a neuroprotective strategy for blocking cell death. Here, the antioxidant action of ferulic acid (FA) on different paths leading to degeneration of recombinant beta-amyloid peptide (rAbeta42) treated cells was investigated. Further, to improve its delivery, a novel drug delivery system (DDS) was used. Solid lipid nanoparticles (SLNs), empty or containing ferulic acid (FA-SNL), were developed as DDS. The resulting particles had small colloidal size and highly negative surface charge in water. Using neuroblastoma cells and rAbeta42 oligomers, it was demonstrated that free and SLNs-loaded FA recover cell viability. FA treatment, in particular if loaded into SLNs, decreased ROS generation, restored mitochondrial membrane potential (Deltapsi(m)) and reduced cytochrome c release and intrinsic pathway apoptosis activation. Further, FA modulated the expression of Peroxiredoxin, an anti-oxidative protein, and attenuated phosphorylation of ERK1/2 activated by Abeta oligomers.

Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties

“…In addition, it exhibits anticholinesterase and free radical scavenging activities and may exert anti-amnesic activity (Kwon et al, 2010). The antioxidant, anti-inflammatory and immunostimulatory ferulic acid (Chao & Lin, 2011) promotes degeneration of recombinant beta-amyloid peptide, as described by Picone et al (2009). Also caffeic acid has neuroprotective effects against A beta-induced toxicity by the inhibition of calcium influx and tau phosphorylation (Sul et al, 2009), and protects neuronal cells against oxidative stress induced cytotoxicity (Jeong et al, 2011).…”

Ferulic acid induces heme oxygenase-1 <i>via</i> activation of ERK and Nrf2

“…FA exhibits a wide range of therapeutic effects against various diseases like cancer, diabetes, and cardiovascular and neurodegenerative diseases (6,7). A wide spectrum of benefits to human health has been attributed to this phenolic compound, at least in part, because of its strong antioxidant activity (8). FA effectively scavenges superoxide anion radicals and inhibits lipid peroxidation (9).…”

Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective

“…[122][123][124] Insufficient use of oral administrated drugs for AD, such as tacrine, memantine, rivastigmine etc, pulls the door open for nanomedicine in neurodegenerative disorders. 125,126 Cerium oxide nanoparticles, 127 SLN of ferulic acid, 128 tempol loaded PLGA nanoparticles, 129 and epigallocatechin-3-gallate (EGCG) phenol coated nanolipids 130 reported to show antioxidant property and degrade amyloid-β. 131 Thioflavin-T (ThT), charged and fluorescent biomarker, detect Aβ in senile plaques.…”