Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective

Soni, Shringika; Ruhela, Rakesh Kumar; Medhi, Bikash

doi:10.15171/apb.2016.044

Cited by 81 publications

(41 citation statements)

References 199 publications

(144 reference statements)

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“…Except for Turcot’s syndrome and Li–Fraumeni syndrome, most GBM patients originate in a sporadic fashion without any known predisposing factors [ 8 ]. Therefore, little is known about the risk factors for brain tumors [ 9 ]. A better understanding of the distribution of GBM may provide indications of etiologic factors and contribute to the search for improved therapies.…”

Section: Introductionmentioning

confidence: 99%

Impact of gender on the survival of patients with glioblastoma

et al. 2018

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Background: Preclinical models have suggested a role for sex hormones in the development of glioblastoma multiforme (GBM). However, the impact of gender on the survival time of patients with GBM has not been fully understood. The objective of the present study was to clarify the association between gender and survival of patients with GBM by analyzing population-based data.Methods: We searched the Surveillance, Epidemiology, and End-Results database who were diagnosed with GBM between 2000 and 2008 and were treated with surgery. Five-year cancer specific survival data were obtained. Kaplan–Meier methods and multivariable Cox regression models were used to analyze long-term survival outcomes and risk factors.Results: A total of 6586 patients were identified; 61.5% were men and 38.5% were women. The 5-year cancer-specific survival (CSS) rates in the male and female groups were 6.8% and 8.3%, respectively (P=0.002 by univariate and P<0.001 by multivariate analysis). A stratified analysis showed that male patients always had the lowest CSS rate across localized cancer stage and different age subgroups.Conclusions: Gender has prognostic value for determining GBM risk. The role of sex hormones in the development of GBM warrants further investigation.

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Section: Introductionmentioning

confidence: 99%

Impact of gender on the survival of patients with glioblastoma

et al. 2018

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“…However, the applications of nanotechnology to drug delivery have been widely studied in vitro and in preclinical assessments and provide alternatives for the treatment of CNS disorders. Currently, there are four main ways to deliver drugs to the CNS: i) invasive delivery; ii) pharmacological approach (free passive movement of drugs across the BBB due to their small molecular size, low hydrogen bonding capacity and low lipophilicity, e.g., reduction of the number of polar groups, which increases drug transfer across the BBB; [79] iii) temporary disruption of the BBB; and iv) nanobased drug delivery systems. [80] Invasive delivery is only reserved for selected cases and is not efficient against brain metastases or neurodegenerative diseases, which require therapeutic agents to be delivered throughout the brain.…”

Section: Diagnostic and Therapeutic Applications Of Nanotechnology Inmentioning

confidence: 99%

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Kumar

Tan

Wong

et al. 2017

Adv Funct Materials

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Unlocking the secrets of the brain is a task fraught with complexity and challenge – not least due to the intricacy of the circuits involved. With advancements in the scale and precision of scientific technologies, we are increasingly equipped to explore how these components interact to produce a vast range of outputs that constitute function and disease. Here, an insight is offered into key areas in which the marriage of neuroscience and nanotechnology has revolutionized the industry. The evolution of ever more sophisticated nanomaterials culminates in network-operant functionalized agents. In turn, these materials contribute to novel diagnostic and therapeutic strategies, including drug delivery, neuroprotection, neural regeneration, neuroimaging and neurosurgery. Further, the entrance of nanotechnology into future research arenas including optogenetics, molecular/ion sensing and monitoring, and piezoelectric effects is discussed. Finally, considerations in nanoneurotoxicity, the main barrier to clinical translation, are reviewed, and direction for future perspectives is provided.

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confidence: 99%

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Incidence of central nervous system (CNS) disorders is still rising despite the significant improvement in the understanding of their pathological mechanisms, and many new drugs, even if virtually able to treat these disorders, have not yet been clinically investigated because of their inability to cross the blood-brain barrier (BBB) and to enter into the brain compartment. [1][2][3] The elaboration of reliable in vitro models of the BBB is extremely relevant both for investigating the development of neurovascular disorders [4][5][6] and for performingThe investigation of the crossing of exogenous substances through the blood-brain barrier (BBB) is object of intensive research in biomedicine, and one of the main obstacles for reliable in vitro evaluations is represented by the difficulties at the base of developing realistic models of the barrier, which could resemble as most accurately as possible the in vivo environment. Here, for the first time, a 1:1 scale, biomimetic, and biohybrid BBB model is proposed.

…”

mentioning

confidence: 99%

“…Incidence of central nervous system (CNS) disorders is still rising despite the significant improvement in the understanding of their pathological mechanisms, and many new drugs, even if virtually able to treat these disorders, have not yet been clinically investigated because of their inability to cross the blood-brain barrier (BBB) and to enter into the brain compartment. [1][2][3] The elaboration of reliable in vitro models of the BBB is extremely relevant both for investigating the development of neurovascular disorders [4][5][6] and for performing…”

mentioning

confidence: 99%

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A 3D Real‐Scale, Biomimetic, and Biohybrid Model of the Blood‐Brain Barrier Fabricated through Two‐Photon Lithography

Marino

Tricinci

Battaglini

et al. 2017

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123

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The investigation of the crossing of exogenous substances through the blood-brain barrier (BBB) is object of intensive research in biomedicine, and one of the main obstacles for reliable in vitro evaluations is represented by the difficulties at the base of developing realistic models of the barrier, which could resemble as most accurately as possible the in vivo environment. Here, for the first time, a 1:1 scale, biomimetic, and biohybrid BBB model is proposed. Microtubes inspired to the brain capillaries were fabricated through two-photon lithography and used as scaffolds for the co-culturing of endothelial-like bEnd.3 and U87 glioblastoma cells. The constructs show the maturation of tight junctions, good performances in terms of hindering dextran diffusion through the barrier, and a satisfactory trans-endothelial electrical resistance. Moreover, a mathematical model is developed, which assists in both the design of the 3D microfluidic chip and its characterization. Overall, these results show the effective formation of a bioinspired cellular barrier based on microtubes reproducing brain microcapillaries to scale. This system will be exploited as a realistic in vitro model for the investigation of BBB crossing of nanomaterials and drugs, envisaging therapeutic and diagnostic applications for several brain pathologies, including brain cancer.

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Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective

Cited by 81 publications

References 199 publications

Impact of gender on the survival of patients with glioblastoma

Impact of gender on the survival of patients with glioblastoma

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

A 3D Real‐Scale, Biomimetic, and Biohybrid Model of the Blood‐Brain Barrier Fabricated through Two‐Photon Lithography

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