Ferulic acid-induced anti-depression and prokinetics similar to Chaihu–Shugan–San via polypharmacology

Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate

“…The ferulic acid is a powerful antioxidant with neuroprotective properties in several models of studies [12], but its anticonvulsant effect has not been reported in previous studies. But analyzing the studies of Zhang et al [16], it was demonstrated that the ferulic acid ( Additionally, this ester derivative of ferulic acid did not cause deficits of the motor coordination and muscle relaxation activities in mice by rod route test when treated in doses that produced an anticonvulsant effect, unlike observed for DZP. Thus, the observed anticonvulsant effect of IF may not be due to its muscle relaxation effects.…”

“…Among these compounds, stands out the ferulic acid that presents several pharmacological activities such as neuroprotective [12], antidiabetic [13], anticancer [14] anti-inflammatory [15], antidepressant [16,17] and mainly antioxidant [18]. In addition, the development of their derivatives that comprise similar chemical structure are promising in relation to a range of new pharmacological properties on the central M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 4 nervous system, which may be related to neuroprotective action [19,20,21].…”

Simultaneous determination of six hydrophilic components in rat plasma after oral administration of Jitai tablet by liquid chromatography–electrospray ionization–tandem mass spectrometry: Application to a pharmacokinetic study

“…Previous chemical investigations and pharmacological studies also discovered that the water-soluble compounds, including DSS, SAA and SAB are the representative agents of Radix Salviae Miltiorrhiae. Additionally, ADL, FA and HSYA are also the important constituents owing to their antiemetics [10], antiinflammatory [11][12][13], antinociceptive [14,15], anxiolytic [16], and sedative tranquilizing effects [17]. Therefore, it is of great value to develop an efficient and reliable bioanalytical protocol for simultaneous determination of these active ingredients in biological matrix with hopefully maximum response and resolution, and to study the PK properties of them to advance the therapeutic applications of JTT.…”

Simo decoction promotes contraction of antral circular smooth muscle mainly via muscarinic M3 receptor

“…A lot of medicines, such as cisapride, domperidone, metoclopramide and mosapride, were employed to relieve gastric dysmotility, but some of these prokinetic agents were far from satisfactory due to side effects (Drolet et al, 2000;Flockhart et al, 2000;Pasricha et al, 2006). Some traditional Chinese medicines, such as SMD, chaihushugan-san (Zhang et al, 2011), have shown their effectiveness to promote gastrointestinal motility. SMD, a representative of prokinetics in traditional Chinese medicine, has been efficiently used to treat constipation and bloating for a long history in China.…”