Simultaneous determination of six hydrophilic components in rat plasma after oral administration of Jitai tablet by liquid chromatography–electrospray ionization–tandem mass spectrometry: Application to a pharmacokinetic study

Wang, Shuping; Liu, Lei; Wang, Lingling; Jiang, Peng; Li, Xiang; Zhang, Wei‐Dong; Liu, Runhui

doi:10.1016/j.jchromb.2012.11.019

Cited by 15 publications

(6 citation statements)

References 40 publications

(38 reference statements)

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“…One could find that the contents of salvianolic acid B were higher than those of tanshinol in YGJZF extracts (Table 2), but in vivo, the opposite was true ( Table 7). is phenomenon is consistent with the previous literature reports [42,43]. In rats' plasma, besides the prototypical-tanshinol, these also include the tanshinol which was metabolized by salvianolic acid B [44].…”

Section: Analytesupporting

confidence: 92%

Pharmacokinetic Comparisons of Different Combinations of Yigan Jiangzhi Formula in Rats: Simultaneous Determination of Fourteen Components by UPLC-MS/MS

Wang

Xie

et al. 2020

Journal of Analytical Methods in Chemistry

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A rapid, specific, and sensitive analysis for simultaneous determination of fourteen components (daidzein, fermononetin, apigenin, luteolin, puerarin, ononin, calycosin-7-O-β-D-glucoside, tanshinol, rosmarinic acid, alkanoic acid, salvianolic acid B, berberine, jatrorrhizin, and palmatine) of Yigan Jiangzhi formula (YGJZF, a clinical experienced formula for damp-heat syndrome) in rat plasma was developed and validated using ultraperformance liquid chromatography coupled with mass spectrometry. Lower limit of quantitation ranged from 0.2–10.0 ng/mL, and the calibration curves showed good linearity over 500 times of measuring range. The validated method was successfully applied to the pharmacokinetics investigation of the fourteen compounds in rat plasma after oral administration of two different doses of YGJZF. Compared with the low-dose group of YGJZF, the high-dose group showed significant increase (P<0.01 or P<0.05) in maximum plasma concentration, maximum concentration time, and area under the plasma concentration-time curve and decrease (P<0.01 or P<0.05) in clearance of most of the fourteen analytes, which suggested that the bioavailability of these components could be enhanced by increasing dosage. The above results may provide useful information for cognizing the relationship between in vitro and in vivo data of the fourteen bioactive ingredients of YGJZF and further guiding rational clinical drug prescription.

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Section: Analytesupporting

confidence: 92%

Pharmacokinetic Comparisons of Different Combinations of Yigan Jiangzhi Formula in Rats: Simultaneous Determination of Fourteen Components by UPLC-MS/MS

Wang

Xie

et al. 2020

Journal of Analytical Methods in Chemistry

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“…After administration, HSYA was absorbed quickly and eliminated very fast. The T max value of HYSA was about 1 h and the plasma concentration decreased to lower than the LLOQ level after 5 h. The result was coincident with the reported pharmacokinetic behaviors of HYSA in rats after administration of HYSA or TCM containing HYSA, showing that the T max was from 0.3 to 2 h and the t 1/2 was around 2 h (Jin et al, ; Wang, Liu, et al, ).…”

Section: Resultssupporting

confidence: 69%

“…Some LC–MS/MS methods were developed for simultaneous analysis of CAG, calycosin and/or ASIV as well as other components in bio‐samples (Liu et al, ; Shaw, Lin, & Tsai, ; Shi et al, ). Some LC–MS/MS methods were established to quantify HSYA with/without other compounds in rat or human plasma (Jin et al, ; Li et al, ; Wang, Liu, et al, ; Wen, Yang, et al, ). In the published LC–MS/MS methods, CAG, calycosin and ASIV were detected most frequently in positive ionization mode while HSYA was monitored in negative mode.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of major components of Huangqi–Honghua extract in rat plasma using LC–MS/MS and application to a pharmacokinetic study

Wang

Qiao

et al. 2019

Biomedical Chromatography

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A sensitive and reliable LC-MS/MS method was developed and validated for simultaneous quantification of the major components of Huangqi-Honghua extact in rat plasma, including hydroxysafflor yellow A (HSYA), astragaloside IV (ASIV), calycosin-calycosin-3′-O-sulfate (C-3′-S). After extraction by protein precipitation with acetonitrile and methanol from plasma, the analytes were separated on a Hypersil BDS C 18 column by gradient elution with acetonitrile and 5 mM ammonium acetate. The detection was carried out on a triple quadrupole tandem mass spectrometer equipped with electrospray ionization source switched between negative and positive modes.HSYA was monitored in negative ionization mode from 0 to 4.9 min, and ASIV, CAG, calycosin, C-3′-G and C-3′-S were determined in positive ionization mode from 4.9 to 10 min. The lower limits of quantification of the analytes were 6.25 ng/mL for HSYA, 0.781 ng/mL for CAG and 1.56 ng/mL for ASIV and calycosin. The intra-and inter-assay precision (RSD) values were within 13.43%, and accuracy (RE) ranged from −8.75 to 9.92%. The validated method was then applied to the pharmacokinetic study of HSYA, ASIV, CAG, calycosin, C-3′-G and C-3′-S in rat after an oral administration of Huangqi-Honghua extract.

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“…Up to now, although some methods based on LC-MS have been reported for the determination of several of the six compounds in rat plasma after oral administration of various prescriptions or extracts for traditional Chinese medicine (TCM), such as Radix Paeoniae Rubra extract [19], Jitai tablet [20], Polygonum capitatum extract [21] and so on. For the complexity of TCM, the pharmacokinetic profiles and parameters might be significantly different, which should not be adopted for GFC.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of six bioactive constituents of Guizhi Fuling Capsule in rat plasma by UHPLC–MS/MS: Application to a pharmacokinetic study

Zhao

Xiong

Yang

et al. 2015

Journal of Chromatography B

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Simultaneous determination of six hydrophilic components in rat plasma after oral administration of Jitai tablet by liquid chromatography–electrospray ionization–tandem mass spectrometry: Application to a pharmacokinetic study

Cited by 15 publications

References 40 publications

Pharmacokinetic Comparisons of Different Combinations of Yigan Jiangzhi Formula in Rats: Simultaneous Determination of Fourteen Components by UPLC-MS/MS

Pharmacokinetic Comparisons of Different Combinations of Yigan Jiangzhi Formula in Rats: Simultaneous Determination of Fourteen Components by UPLC-MS/MS

Simultaneous determination of major components of Huangqi–Honghua extract in rat plasma using LC–MS/MS and application to a pharmacokinetic study

Simultaneous determination of six bioactive constituents of Guizhi Fuling Capsule in rat plasma by UHPLC–MS/MS: Application to a pharmacokinetic study

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