Fertility sparing therapy for metastatic gestational trophoblastic disease in young patients

Milenkovic, V.; Jeremić, K.; Lazović, Biljana; Stefanović, Aleksandar; Mirković, Ljiljana; Kadija, Saša

doi:10.1016/j.ijgo.2011.09.020

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Hysterectomy is generally not necessary, but is an option for patients who are no longer interested in future fertility and may be necessary for patients unresponsive to multi-agent chemotherapy [5]. However, some patients with future fertility desire and unresponsive to chemotherapy may benefit from partial hysterectomy or tumor resection from the uterus [14,15].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection

Chen

Jhuang

Lin

et al. 2017

Taiwanese Journal of Obstetrics and Gynecology

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Section: Discussionmentioning

confidence: 99%

Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection

Chen

Jhuang

Lin

et al. 2017

Taiwanese Journal of Obstetrics and Gynecology

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“…There are few publications, describing urgent localized uterine resection, followed by uterine reconstruction [6,[14][15][16][17][18]. The limited number of clinical observations is apparently caused by the fact that such treatment option was considered as wrong earlier.…”

Section: Discussionmentioning

confidence: 99%

“…The issue concerning the uterus organ-preserving surgeries has been little studied up to now, especially in metastatic GTN [14]. Indications, contra-indications and complications after such surgeries are not described in the literature.…”

Section: Low-invasive Techniquesmentioning

confidence: 99%

Fertility-Sparing Hysterotomy in Malignant Trophoblastic Tumours Treatment

Tsip¹

2017

EUREKA: Health Sciences

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The aim is to improve treatment efficacy and life quality of patients with malignant trophoblastic tumours. Fertility-sparing hysterotomy with uterine reconstruction was carried in 16 patients aged of 17 to 32 years: 2 cases due to urgent and 13 – due to planned indications. On the basis of research, the indications for the urgent and planned fertility-sparing hysterotomy with uterine reconstruction in patients with malignant trophoblastic tumours were formulated. No postoperative complications. Steady remission in all cases. Follow up from 1 to 17 years (averaged 9.2 years). 1. Localized uterine resection with uterine reconstruction – the method of choice in malignant trophoblastic tumours surgical treatment; 2. Fertility-sparing hysterotomy with uterine reconstruction is only possible in centers which are experienced in the complex multimodality treatment of gestational trophoblastic neoplasms; 3. Basic requirement of fertility-sparing surgery is beginning adjuvant chemotherapy as soon as possible.

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