Fertility drugs and the risk of breast and ovarian cancers: results of a long-term follow-up study

Potashnik, G.; Lerner‐Geva, Liat; Genkin, Leonid; Chetrit, Angela; Lunenfeld, Eitan; Porath, Avi

doi:10.1016/s0015-0282(99)00085-0

Cited by 148 publications

(96 citation statements)

References 18 publications

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“…Finally, thirty (Aboudaoud, 1971;Henquin et al, 1994;Potashnik et al, 1999;Nustas et al, 2002;Alothaimeen et al, 2004;Gilani and Kamal, 2004;Yavari et al, 2005;Fakri et al, 2006;Lerner et al, 2006;Shaham et al, 2006;Faheem et al, 2007;Shema et al, 2007;Naieni et al, 2007;Mahouri et al, 2007;Katz et al, 2008;Peled et al, 2008;Montazeri et al, 2008;Saadat et al, 2008;Saleh et al, 2008;Ahmad et al, 2009;Calderon et al, 2009;Majid et al, 2009;Awatef et al, 2010;Abdulbari et al, 2010;Bidgoli et al, 2011;Ghiasvand et al, 2011;Hajian and Ahangar, 2011;Javed et al, 2011;Kloong et al, 2011;Tehranian et al, 2011) eligible studies included in the meta-analysis after quality assessment (Table 2 and Figure 1). Twenty five case-control studies, one nested case-control and four cohort studies were included.…”

Section: Search Resultsmentioning

confidence: 99%

Risk Factors of Breast Cancer in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis

Namiranian¹,

Moradi‐Lakeh²,

Razavi-Ratki³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Identifying risk factors of breast cancer is a key point for preventive strategies to reduce the incidence. The aim of current study was to determine most important risk factors for breast cancer in the Eastern Mediterranean Region (EMR) using a systematic review. Materials and Methods: PubMed, Scopus, Web of Science till August 24, 2012 and the reference lists of all included studies were searched. Analytic studies which had reported odds ratios (OR), relative risk (RR) or required data to calculate them were included. A total of 343 studies were critically appraised and finally 30 studies were meta-analyzed. Heterogeneity between the studies was assessed by I² and Cochran's Q. Egger's test was used to assess publication bias. Results: Twenty five casecontrol studies, one nested case-control and four cohort studies were included. The largest ORs were obtained for history of no live birth (2.25; 95%CI: 1.58-3.18), body mass index (BMI) more than 30 (2.21; 95%CI: 1.71-2.36), age at first pregnancy more than 30 years old (1.52; 95%CI: 1.30-1.77) and meat consumption more than three times per week (1.39; 95%CI: 1.03-1.87). The other important predictors were higher education and smoking as risk factors, physical activity and ovulatory stimulating medication as protective factors. Conclusions: The most important predictors of breast cancer in EMR were history of no live birth, BMI more than 30, age at first pregnancy more than 30 years old, physical inactivity and smoking. Almost all these risk factors are consistent with known risk factors for this cancer in other parts of the world.

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Section: Search Resultsmentioning

confidence: 99%

Risk Factors of Breast Cancer in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis

Namiranian¹,

Moradi‐Lakeh²,

Razavi-Ratki³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…However, we did perform analyses on the subsets of women who had information about causes of infertility or oral contraceptive use, but these adjustments did not change the overall estimates, indicating that these risk factors are not confounders in the association between the use of fertility drugs and the risk of breast cancer in our study. In addition, most previous studies that have examined the association between fertility drugs, causes of infertility, and breast cancer risk (22,24,26,39), found that adjustment for causes of infertility did not change the risk estimates associated with use of fertility drugs. However, both our results and the results from previous studies may partly reflect methodologic differences and weaknesses in the assessment of cause of infertility, for example, no knowledge of to what extent the woman in question has, in fact, been evaluated for all causes of infertility or not, and this topic clearly need further assessment in future well-conducted studies.…”

Section: Discussionmentioning

confidence: 97%

“…Results, thus far, have been contradicting, as most studies found no association between use of fertility drugs and risk of breast cancer (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), two studies found that fertility drugs increase the risk of breast cancer (23,24), whereas two other studies found that use of fertility drugs decrease the risk of developing breast cancer (25,26). Many of the previous studies have faced various methodologic limitations, for example, low statistical power due to a low number of breast cancer cases and inability to control for potential confounders.…”

Section: Introductionmentioning

confidence: 99%

Risk of Breast Cancer After Exposure to Fertility Drugs: Results from a Large Danish Cohort Study

Jensen

Sharif

Svare

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Few epidemiologic studies have examined the association between fertility drugs and breast cancer risk, and results have been contradicting. Using data from the largest cohort of infertile women to date, the aim of this study was to examine the effects of fertility drugs on breast cancer risk overall and according to histologic subtypes. Method: A cohort of 54,362 women with infertility problems referred to all Danish fertility clinics between 1963 and 1998 was established. A detailed data collection, including information of type and amount of treatment, was conducted. We used case-cohort techniques to calculate rate ratios (RR) of breast cancer associated with use of five groups of fertility drugs, after adjustment for parity status. Results: Three hundred thirty-one invasive breast cancers were identified in the cohort during follow-up through 1998. Analyses within cohort showed no overall increased breast

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“…However, there are publications, which have not found a relation between infertility treatments and any cancer development (Potashnik et al, 1999, Doyle et al, 2002Dor et al, 2002;Lerner-Geva et al, 2010;Brinton et al, 2004). For example, a case-control study (1380 pairs) showed no risk for IVF treatment even among women who carry mutations in breast cancer susceptibility gene 1 (BRCA1) or BRCA2 gene (Kotsopoulos et al, 2008).…”

Section: The Risk For Cancer Development After Ivf Treatmentmentioning

confidence: 99%

The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland

Tamm¹,

Suhorutshenko²,

Rõõm³

et al. 2012

Steroids - Basic Science

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Fertility drugs and the risk of breast and ovarian cancers: results of a long-term follow-up study

Cited by 148 publications

References 18 publications

Risk Factors of Breast Cancer in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis

Risk Factors of Breast Cancer in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis

Risk of Breast Cancer After Exposure to Fertility Drugs: Results from a Large Danish Cohort Study

The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland

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