The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland

Tamm, Karin; Suhorutshenko, Marina; Rõõm, Miia; Simm, Jaak; Metsis, Madis

doi:10.5772/25815

Cited by 2 publications

(2 citation statements)

References 149 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most mammals, P4 is indispensable for the establishment and maintenance of pregnancy [ 1 ]. P4 works to develop tissue and blood vessels in the endometrium to assist in implantation [ 20 ] and also downregulates prostaglandin F2α in the bovine endometrium [ 21 ], which supports survival and development of the conceptus [ 22 ]. Furthermore, P4 suppresses apoptosis in bovine luteal cells [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Induction of the Expressions of Antioxidant Enzymes by Luteinizing Hormone in the Bovine Corpus Luteum

Kawaguchi

Sakumoto

Okuda

2013

Journal of Reproduction and Development

View full text Add to dashboard Cite

Luteoprotective mechanisms of luteinizing hormone (LH) involved in the maintenance of bovine corpus luteum (CL) function have not been completely clarified. Since antioxidant enzymes are well documented as antiapoptotic factors in the CL of many mammals, we hypothesized that the luteoprotective action of LH is mediated by stimulating the local production and action of antioxidant enzymes. To test the above hypothesis, in the present study, we examined the mechanisms involved in the luteoprotective actions of LH. Cultured bovine luteal cells obtained from the CL at the mid-luteal stage (days 8–12 of the estrous cycle) were treated with LH (10 ng/ml), onapristone (OP; a specific progesterone receptor antagonist, 100 μM) and diethyldithiocarbamate [DETC; an inhibitor of superoxide dismutase (SOD), 100 μM] for 24 h. LH in combination with or without OP significantly increased the mRNA and protein expressions of manganese SOD (Mn-SOD) and catalase (CATA) and SOD activity. While LH alone significantly increased the mRNA and protein expressions of SOD containing copper and zinc (Cu,Zn-SOD), OP in combination with or without LH significantly decreased the mRNA and protein expressions of Cu,Zn-SOD. In addition, Cu,Zn-SOD, Mn-SOD and CATA mRNA expressions were higher at the mid luteal phase than the other luteal phases. LH in combination with DETC significantly decreased LH-increased cell viability. The overall results suggest that LH increases cell viability by LH-increased antioxidant enzymes, resulting in maintenance of CL function during the luteal phase in cattle.

show abstract

Section: Discussionmentioning

confidence: 99%

Induction of the Expressions of Antioxidant Enzymes by Luteinizing Hormone in the Bovine Corpus Luteum

Kawaguchi

Sakumoto

Okuda

2013

Journal of Reproduction and Development

View full text Add to dashboard Cite

show abstract

“…The estrogen α receptor has a higher affinity for estrogen, and it is the dominant form of the normal endometrium. Recent studies have shown that ERα and ERβ express the human tissue endometriosis, but the distribution of iso form is different between eutopic endometrium and ovarian, endometrial tissue [4], [5].…”

Section: Introductionmentioning

confidence: 99%

The Comparison of Er α Expression Between Endometriosis with No Endometriosis

Syafardi

Siregar

Kaban

et al. 2019

SMJ

View full text Add to dashboard Cite

Estrogen receptors (ER) play an important role in mediating action. The ER α has a higher affinity for estrogen and the dominant form of the normal endometrium. A cross-sectional study from an ectopic tissue of endo-metriosis and normal was examined for immunohistochemistry. This research was conducted from November 2015 until the sample complete. The analysis was performed using Fisher Exact test, p <0.05 was considered to any difference of estrogen alpha receptor expression between endometriosis patients with no endometriosis. REα is more dominant in normal endometrium, whereas in the case of endometriosis in the presence of many negative expression of REα then the assumption that REβ is a receptor that many encountered. There is a dif-ference in the expression of REα between endometriosis with no endometriosis.

show abstract

The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland

Cited by 2 publications

References 149 publications

Induction of the Expressions of Antioxidant Enzymes by Luteinizing Hormone in the Bovine Corpus Luteum

Induction of the Expressions of Antioxidant Enzymes by Luteinizing Hormone in the Bovine Corpus Luteum

The Comparison of Er α Expression Between Endometriosis with No Endometriosis

Contact Info

Product

Resources

About