Risk Factors of Breast Cancer in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis

Namiranian, Nasim; Moradi‐Lakeh, Maziar; Razavi-Ratki, Seid Kazem; Doayie, Mahdyie; Nojomi, Marzieh

doi:10.7314/apjcp.2014.15.21.9535

Cited by 39 publications

(27 citation statements)

References 43 publications

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“…Our review results were consistent with the results of other studies (6,10,(24)(25)(26)(27). The meta-analysis results of Namiranian et al (2014) were also consistent with the results of the present study. Their results demonstrated the pooled OR for the overweight women (25 < BMI < 30) was 1.71 (95%CI = 1.09 -2.68) and the risk of breast cancer in obese women (BMI > 30) was higher than women with normal BMI (pooled OR = 2.21, 95%CI = 1.71 -2.36) (11).…”

Section: Discussionsupporting

confidence: 82%

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Body Mass Index and Risk of Breast Cancer: A Systematic Review and Meta-Analysis in Iran

et al. 2017

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Background: Various studies in Iran on the role of BMI higher than normal (BMI ≥25) on breast cancer have reported different results.Objective: The aim of this systematic review and meta-analysis is to estimate the odds ratio of overweightness and obesity as risk factors of breast cancer in studies conducted in Iran.Evidence Acquisition: The following main databases were searched from 2004 to 2014 to find related articles: PubMed, Web of Science, Google Scholar, Scopus and Iranian databases (SID and Magiran), breast cancer conferences held in Iran, key journals, and the references of the selected articles. Keywords were: Cancer, Tumor, Neoplasm, Neoplasia, Carcinoma, Malignancy, Malignant, Benign. The combination with OR and added it to search field with AND to words such as Iran and breast was used as the search strategy. The observational studies (cohort, case-control, and cross-sectional) in Iran that had reported the relation between BMI and breast cancer in Persian and English were searched. There were no limitations in terms of age, race, ethnicity, and marital status for women. The exposure was BMI ≥ 25 (overweight and obese) and the outcome was breast cancer with pathological confirmation.Two reviewers separately used the STROBE checklist for quality assessment, critically appraised papers and extract the data. The overall estimate was the odds ratio. Results:Of 4396 studies, after evaluation of heterogeneity, 7 case-control studies with a sample size of 33552 were included in the meta-analysis. A significant relation was observed between obesity (OR = 1.81, 95% CI = 1.24 -2.64) and odds of breast cancer. A significant relation was also observed between overweightness and odds of breast cancer (OR = 1.46, 95% CI = 1.13 -1.89).Conclusions: Meta-analysis results showed a significant relation between obesity and overweight with risk of breast cancer in Iranian women. We recommended Iranian women to be aware of the effect of weight on breast cancer and encouraged them to decrease their weight via physical activity and diet control.

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Section: Discussionsupporting

confidence: 82%

“…Another review by Namiranian et al on the risk factors of breast cancer in the Eastern Mediterranean Region (EMRO) demonstrated that overweightness and obesity increase the risk of breast cancer and this association was statistically significant (11).…”

Section: Introductionmentioning

confidence: 99%

Body Mass Index and Risk of Breast Cancer: A Systematic Review and Meta-Analysis in Iran

et al. 2017

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“…Apesar de a idade não ter apresentado diferença estatística quando feita comparação entre os gêneros masculino e feminino, pôde-se Perfil clínico dos pacientes atendidos em um ambulatório de fisioterapia em oncologia do município de São Paulo observar que a média de idade dos pacientes que se apresentaram no ambulatório de fisioterapia foi de 56 anos, portanto uma média elevada. Esse fato corrobora com outros estudos que relacionam a idade como fator de risco para o desenvolvimento do câncer 14,15 e ainda com estudos que associam o tratamento fisioterapêutico no pós-operatório do câncer de mama em uma população com a faixa etária aproximada com a encontrada nos resultados do presente estudo 16 . Em contrapartida, apesar de a idade não ter apresentado diferença entre os gêneros, outra característica da população atendida que apresentou diferença significativa foi o IMC, o que era esperado devido à diferença significativa também encontrada no gênero dos pacientes.…”

Section: Discussionunclassified

“…Em contrapartida, apesar de a idade não ter apresentado diferença entre os gêneros, outra característica da população atendida que apresentou diferença significativa foi o IMC, o que era esperado devido à diferença significativa também encontrada no gênero dos pacientes. Considera--se que taxas elevadas de IMC estejam relacionadas ao aumento do risco para desenvolvimento do câncer 15 , como apontado no estudo de Montazari, et al 17 , que verificou diferença significativa (p = 0,004) no IMC do grupo com câncer de mama que apresentou média de 27,9 ± 3,9 kg/m 2 comparado à média do IMC do grupo controle de 26,3 ± 4,3 kg/m 2 . Os dados de gênero, IMC e idade corroboram com Ricci, et al 10 , que verificaram 196 mulheres brasileiras com câncer de mama, tendo a idade comparável à amostra do presente estudo, assim como IMC, que mostrou sobrepeso e obesidade, tendo a quimioterapia em determinados regimes como fator associado ao aumento de peso.…”

Section: Discussionunclassified

Perfil clínico dos pacientes atendidos em um ambulatório de fisioterapia em oncologia do município de São Paulo

et al. 2014

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ResumoOs avanços no tratamento das neoplasias têm favorecido maiores taxas de sobrevida, aumentando a demanda da reabilitação dos pacientes com câncer, sendo a fisioterapia uma das áreas em amplo crescimento. Porém, essa população possui perfil, demanda e realidade bem diferentes, sendo necessário o conhecimento de suas características para melhor elaborar estratégias de atuação e condutas dentro da área de fisioterapia em oncologia. O objetivo deste estudo foi identificar o perfil clínico dos pacientes atendidos em um ambulatório de fisioterapia em oncologia. Foram analisados 105 prontuários para a coleta dos dados sociodemográficos e clínicos de um ambulatório de fisioterapia em oncologia do município de São Paulo, de agosto de 2008 a julho de 2010, sendo 11 (10,5%) excluídos. Para a análise estatística foi utilizado o teste de igualdade de duas proporções para avaliar a distribuição relativa das variáveis e Mann-Whitney para comparação destas. Dos 94 prontuários analisados, 63,8% (n = 60) eram do gênero feminino (p < 0,001), com faixa etária média de 56,3 ± 13,3 anos e IMC de 27,09 ± 5,88 kg/m 2 . O diagnóstico médico mais frequente foi o câncer de mama em 44,4% (n = 44; p < 0,05). A maioria estava entre o segundo e quinto ano (33%; n = 31) de evolução da doença. O tratamento cirúrgico foi o mais realizado (94,7%; n = 89; p < 0,001). O diagnóstico fisioterapêutico mais encontrado foi de alterações vasculares e linfáticas (87,2%; n = 82; p < 0,001). A queixa principal dos pacientes foi de dor (55,3%; n = 52) e edema (51,1%; n = 48; p = 0,559). Pode-se concluir que o perfil clínico dos pacientes se caracterizou por mulheres acima de 50 anos, com sobrepeso, em pós-operatório tardio de câncer de mama, apresentando dor e linfedema nos membros. Palavras-chave:Neoplasias. Perfil de Saúde. Fisioterapia. AbstractAdvances in cancer treatment has been favoring higher survival rates, increasing demand of rehabilitation of cancer patients, being physical therapy one of the areas in a higher growth. However, this population has very different profiles, demands and realities, requiring the knowledge of its features to better develop action strategies and conducts in the area of physical therapy in oncology. The objective of this study was to identify the clinical profile of patients assisted in a physical therapy outpatient in Oncology. One hundred five medical records were analyzed for demographic and clinical data collection in a outpatient physiotherapy service of Sao Paulo city, from August 2008 to July 2010, being 11(10.5%) excluded. Statistical analysis was performed using the test for equality of two proportions to evaluate the relative distribution of variables, which were compared using the Mann-Whitney test. Among those 94 medical records, 63.8% (n = 60) were female (p < 0.001), with a mean age of 56.3 ± 13.3 years and they had a BMI of 27.09 ± 5.88 kg/m². The most prevalent medical diagnosis was breast cancer in 44.4% (n = 44; p < 0.05). Most patients were between the second and the fifth year (33%; n = 31) of di...

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“…In a systematic review in 2014, Namiranian et al showed that a first pregnancy after 30 years of age and nulliparous women are strongly associated with the risk of breast cancer. 24 The prolonged interval between menarche and first pregnancy is associated with HR+ breast cancer, and a short interval between these events is related with TNBC. 10 Mesharam et al explained that experiencing menopause at an age of ≥50 years compared with women who had menopause before 45 years of age is associated with a 7.9-times greater risk of developing breast malignancies.…”

Section: Prolonged Interval Between Menarche and First Pregnancymentioning

confidence: 99%

Reproductive Factors and Breast Cancer Risk

Tarannum¹,

Pittala²,

Deekshitha³

et al. 2019

Int J Med Rev

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A neoplasm, also referred to as a tumor, is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of normal tissue and remains in the same excessive manner even after removal of the stimuli which evoked the changes. Tumors may be either benign or malignant. Benign tumors remain localized and are amenable to surgical removal, whereas malignant tumors, i.e. cancerous ones, adhere to any part in an obstinate manner, often invade surrounding tissue, and metastasize to distinct sites. Breast cancer occupies second place as the most occurring cancer in terms of incidence. Breast cancer is a heterogenous cancer, mostly linked with reproductive and hormonal factors in its occurrence. Nulliparous, younger age at menarche, early age pregnancy, older age at first live birth, late menopause, prolonged interval between menarche and first pregnancy, repeated abortions, first pregnancy after 35 years, and no/less breastfeeding are major risk factors for breast malignancies. Recent studies have shown that the implications of reproductive and hormonal factors in patients with breast cancer are associated mostly with BRCA1 (breast cancer gene 1) and BRCA2 (breast cancer gene 2) gene mutations.

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Risk Factors of Breast Cancer in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis

Cited by 39 publications

References 43 publications

Body Mass Index and Risk of Breast Cancer: A Systematic Review and Meta-Analysis in Iran

Body Mass Index and Risk of Breast Cancer: A Systematic Review and Meta-Analysis in Iran

Perfil clínico dos pacientes atendidos em um ambulatório de fisioterapia em oncologia do município de São Paulo

Reproductive Factors and Breast Cancer Risk

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