Fertility and infertility implications in rheumatoid arthritis; state of the art

Fattah, Abolfazl; Asadi, Amirhooman; Shayesteh, Mohammad Reza; Hesari, Forough Hatefi; Jamalzehi, Sirous; Abbasi, Mojtaba; Mousavi, Mohammad Javad; Aslani, Saeed

doi:10.1007/s00011-020-01362-w

Cited by 20 publications

(18 citation statements)

References 91 publications

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“…Among the three most linked conditions, only rheumatoid arthritis (RA) has been related to fertility (Fattah et al, 2020) so far, maybe because the other two (i.e., allergic reaction and hypersensibility) show very high variability and multiple interconnected components. A recent review by Fattah and coll.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…A recent review by Fattah and coll. (2020) provided several proofs regarding the relationship between women with RA and fertility, which seems declined and dependent on inflammatory milieu, mother age, hampered sexual activity and negative effects of non-steroidal anti-inflammatory drugs on ovarian function (Fattah et al, 2020). Indeed, it has been found that women with RA deliver fewer children when compared to healthy women (Fattah et al, 2020).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…(2020) provided several proofs regarding the relationship between women with RA and fertility, which seems declined and dependent on inflammatory milieu, mother age, hampered sexual activity and negative effects of non-steroidal anti-inflammatory drugs on ovarian function (Fattah et al, 2020). Indeed, it has been found that women with RA deliver fewer children when compared to healthy women (Fattah et al, 2020). The decreased fertility rate in women suffering from RA might be due to a reduced sexual activity (because of pain, fatigue, mental distress, functional limitations), treatment with antirheumatic medications hampering ovulation, as well as, to advanced maternal age, patients' choice, or a combination of all of these factors (Fattah et al, 2020).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…Indeed, it has been found that women with RA deliver fewer children when compared to healthy women (Fattah et al, 2020). The decreased fertility rate in women suffering from RA might be due to a reduced sexual activity (because of pain, fatigue, mental distress, functional limitations), treatment with antirheumatic medications hampering ovulation, as well as, to advanced maternal age, patients' choice, or a combination of all of these factors (Fattah et al, 2020). The results showed here demonstrate that at least 13 genes (CXCL8; CSF2; IL6; LCN2; TNF; VEGFA; IFNG; IL1B; IL10; CP; CXCL2; GC; F1) could be involved in this relationship.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

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Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered

et al. 2022

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Human hypofertility and infertility are two worldwide conditions experiencing nowadays an alarming increase due to a complex ensemble of events. The immune system has been suggested as one of the responsible for some of the etiopathogenic mechanisms involved in these conditions. To shed some light into the strong correlation between the reproductive and immune system, as can be inferred by the several and valuable manuscripts published to date, here we built a network using a useful bioinformatic tool (DisGeNET), in which the key genes involved in the sperm-oviduct interaction were linked. This constitutes an important event related with Human fertility since this interaction, and specially the spermatozoa, represents a not-self entity immunotolerated by the female. As a result, we discovered that some proteins involved in the sperm-oviduct interaction are implicated in several immune system diseases while, at the same time, some immune system diseases could interfere by using different pathways with the reproduction process. The data presented here could be of great importance to understand the involvement of the immune system in fertility reduction in Humans, setting the basis for potential immune therapeutic tools in the near future.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Rheumatoid Arthritismentioning

confidence: 99%

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Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered

et al. 2022

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“…The mean age at diagnosis for patients with RA is around menopause, although some patients are of reproductive age. It Int Arch Allergy Immunol 2022;183:462-469 DOI: 10.1159/000520133 has been recognized for decades that women with RA have a higher risk of decreased fertility, even infertility, which may be caused by age-related ovarian reserve decline, inflammatory cytokines, side effects of drugs, and psychological factors [2,3]. It is reported that patients with RA appear to reach menopause at a younger age.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Ovarian Reserve by Serum Anti-Müllerian Hormone in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis

Zhang

Chen

et al. 2021

Int Arch Allergy Immunol

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Background: The ovarian reserve has been reported to be diminished in patients with rheumatoid arthritis. However, these results are still controversial. Anti-Müllerian hormone (AMH) is considered a reliable biomarker for the ovarian reserve. We thus performed a meta-analysis to evaluate the AMH levels and the effect of DMARDs on the ovarian reserve in rheumatoid arthritis patients. Methods: PubMed, EMBASE, the Cochrane Library, and 2 Chinese databases (CNKI and Wanfang database), up to September 2021, were searched for relevant studies. The Newcastle-Ottawa scale (NOS) was used to assess the quality of the included studies. Pooled standard mean difference (SMD) with 95% confidence intervals (CIs) were determined with the random-effects model. The heterogeneity was described by I2 statistic and p value from the Cochrane Q test. Results: Eight eligible studies (679 patients and 1,460 controls) were included in the meta-analysis. Compared with healthy control, the AMH levels in RA patients were significantly lower with the pooled SMD of −0.40 (95% CI: −0.66 to −0.14). However, in comparison of AMH with and without DMARD treatment, there was no significant difference with the pooled SMD of −0.1 (95% CI: −0.39 to 0.19). Conclusion: The results indicated that there was an increased risk of ovarian failure in RA patients and which is not related to DMARD treatment.

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Reproductive Effect by Rheumatoid Arthritis and Related Autoantibodies

Li,

Zheng

2024

Rheumatol Ther

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Fertility and infertility implications in rheumatoid arthritis; state of the art

Cited by 20 publications

References 91 publications

Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered

Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered

Assessment of the Ovarian Reserve by Serum Anti-Müllerian Hormone in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis

Reproductive Effect by Rheumatoid Arthritis and Related Autoantibodies

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