Fertility after Torsion of the Spermatic Cord

Anderson, Jamie; Williamson, R. C. N.

doi:10.1111/j.1464-410x.1990.tb14715.x

Cited by 79 publications

(49 citation statements)

References 34 publications

(30 reference statements)

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“…Although some authors proposes a reflexive decrease in contralateral testicular blood flow [14]. Electromagnetic and radioisotopic studdisagree, it is generally thought that UTT causes contralateral testicular deterioration and results in diminished ies showing decreased blood flow and increased concentrations of tissue-hypoxia products in the contralateral fertility [1][2][3]. As various surgical pathologies aÂecting the ipsilateral testis also cause deterioration in the contraltestis during UTT strongly support this theory [14][15][16][17].…”

mentioning

confidence: 88%

Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion

Ciftci¹,

Müftüoğlu

Çakar

et al. 1997

British Journal of Urology

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Objective To evaluate contralateral testicular blood flow eral testes of the torsion group were collapsed. The diÂerence between the contralateral testes of the two by histological examination of arterioles during ipsilateral testicular torsion.groups and between the ipsilateral and contralateral testes in the torsion group were significant. The diamMaterials and methods The study comprised two groups of 20 male albino rats (weight 250-270 g). The eter of uncollapsed arterioles did not diÂer significantly among either testes of the control and torsion groups control group underwent a sham operation, while in the second group the left testes were twisted clockwise and either testes in each group. Both testes in the torsion group had significantly more arterioles conby 720°. All rats underwent bilateral orchidectomy 24 h after the initial intervention. Three slides for taining blood cells than those in the control group. The diÂerence between the testes in the torsion group each testis (n=240) were evaluated randomly while unaware of treatment to determine the total number was also significant, but was not in the control group. Conclusion There was histological evidence of decreased of arterioles, the percentage of collapsed and open arterioles, the diameter of open arterioles and the blood flow in the contralateral testis during unilateral testicular torsion; contralateral testicular damage presence or absence of blood cells in the lumen. DiÂerences were assessed using t-tests for paired and during unilateral testicular torsion may result from hypoxia caused by decreased blood flow. independent samples. Results Very few arterioles were collapsed in both testes Keywords Spermatic cord torsion, testicular injury, contralateral of the control group and in the ipsilateral testes of the torsion group, but half the arterioles in the contralatepisodes of contralateral testicular torsion and underlying

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mentioning

confidence: 88%

Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion

Ciftci¹,

Müftüoğlu

Çakar

et al. 1997

British Journal of Urology

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“…Attempts at grading the severity of testicular injury after torsion have used such general parameters as fertility rates [6], testicular size, testicular weight, testicular histology [7], and semen analyses [8]. The results, however, have been conflicting.…”

Section: Introductionmentioning

confidence: 99%

“…Adult male rats were anaesthetized using 20 mg/ ml of xylazine and 10 mg/ml of ketamine and the testis was rotated as described [6]. Briefly, the testis was exteriorized through a low midline laparotomy, the gubernaculums was divided and the testis was freed from the epididymo-testicular membrane.…”

Section: Experimental Testicular Torsionmentioning

confidence: 99%

Testicular Torsion-Detorsion- Histological and Biochemical Changes in Rat Testis

Fa¹,

Elfagih²,

Sheriff³

et al. 2012

J Cytol Histol

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“…Therefore, this high rate of testicular torsion makes it an important factor leading to infertility in men. It seems to be the second most common reason for emergency surgical in young men in Britain [8].…”

Section: Introductionmentioning

confidence: 99%

Alteration of spermatogenesis following spermatogonial stem cells transplantation in testicular torsion-detorsion mice

Azizollahi

Aflatoonian

Gilani

et al. 2016

J Assist Reprod Genet

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Purpose Testicular ischemia is the main consequence of testicular torsion, in both clinical and experimental aspects. Preservation and auto-transplantation of spermatogonial stem cells (SSCs) could be a new treatment for infertility in testicular ischemia following testicular torsion. Methods To apply the idea in this study, animals were randomly divided into four groups of control, sham, with torsion, and with torsion followed by transplantation (TT). Isolated SSCs from neonatal mice were cultured and identified by flow cytometry (C-KIT − , INTEGRIN β 1 + ) and RT-PCR (Reverse transcription polymerase chain reaction) for specific spermatogonial cell markers (Oct4, Gfrα-1, Plzf, Vasa, Itgα 6 , and Itgβ 1 ). SSCs were transplanted upon a 2-h testicular torsion in the TT group. Cultured cells were transplanted into ischemia reperfusion testicle 2 weeks post-testicular torsion. Eight weeks after SSCs transplantation, the SSCs-transplanted testes and epididymis were removed for sperm analysis, weight and histopathological evaluation, and pre-and postmeiotic gene expression assessment by qRT-PCR. Results Our findings indicated that all evaluated parameters (epididymal sperm profile, Johnsen score, Plzf, Gfrα-1, Scp-1, Tekt-1 expressions, and histopathological profile) were significantly decreased following testicular torsion (group 3) when compared to the control group (p ≤ 0.05). However, all abovementioned parameters showed a significant increase/improvement in torsion-transplantation group compared to torsion group. However, these parameters in Capsule SSCs transplantation increase relative expression of pre-/postmeiotic genes and improve sperm parameters and testis structure in testicular torsion-detorsion mice.Summary sentence SSCs transplantation increase relative expression of pre-/post-meiotic genes and improve sperm parameters and testis structure in the ischemic condition. the TT group were significantly lower in the sham and control groups (p ≤ 0.05).Conclusion SSCs transplantation could up-regulate the expression of pre-and post-meiotic genes in testicular ischemia, which resulted in improvement of both testicular function and structure after testicular torsion.

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Fertility after Torsion of the Spermatic Cord

Cited by 79 publications

References 34 publications

Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion

Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion

Testicular Torsion-Detorsion- Histological and Biochemical Changes in Rat Testis

Alteration of spermatogenesis following spermatogonial stem cells transplantation in testicular torsion-detorsion mice

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