Ferroptosis in Low-Grade Glioma: A New Marker for Diagnosis and Prognosis

Liu, Yan; Xu, Zhennan; Jin, Tao; Xu, Ke; Liu, Mingfa; Xu, Haixiong

doi:10.12659/msm.921947

Cited by 29 publications

(30 citation statements)

References 28 publications

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“…It was surprising that ALOX12 and ALOX15 , which are two members of lipoxygenase family, seemed to be unaltered due to very low expression in these groups. In consistent with our result, a previous study also illustrated unalterations of ALOX12 and ALOX15 in different glioma grades 47 . In contrast, it was intriguing that the differential expression of ALOX5 was observed among GBM, LGG, and NON‐TUMOR tissues.…”

Section: Discussionsupporting

confidence: 93%

Ferroptosis‐related gene signature predicts prognosis and immunotherapy in glioma

et al. 2021

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Aims Glioma is a highly invasive brain tumor, which makes prognosis challenging and renders patients resistant to various treatments. Induction of cell death is promising in cancer therapy. Ferroptosis, a recently discovered regulated cell death, can be induced for killing glioma cells. However, the prognostic prediction of ferroptosis‐related genes (FRGs) in glioma remains elusive. Methods The mRNA expression profiles and gene variation and corresponding clinical data of glioma patients and NON‐TUMOR control were downloaded from public databases. Risk score based on a FRGs signature was constructed in REMBRANDT cohort and validated in other datasets including CGGA‐693, CGGA‐325, and TCGA. Results Our results demonstrated that the majority of FRGs was differentially expressed among GBM, LGG, and NON‐TUMOR groups (96.6%). Furthermore, the glioma patients with low‐risk score exhibited a more satisfactory clinical outcome. The better prognosis was also validated in the glioma patients with low‐risk score no matter to which grade they were affiliated. Functional analysis revealed that the high‐risk score group was positively correlated with the enrichment scores for immune checkpoint blockade‐related positive signatures, indicating the critical role of glioma immunotherapy via risk score. Conclusion A novel FRGs‐related risk score can predict prognosis and immunotherapy in glioma patients.

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Section: Discussionsupporting

confidence: 93%

Ferroptosis‐related gene signature predicts prognosis and immunotherapy in glioma

et al. 2021

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“…Mesenchymal stem cells (MSCs) are a type of non-hematopoietic stem cells originated from the stroma, which can alleviate hepatocyte damage and accelerate liver regeneration, participate in anti-inflammatory effects, and regulate immunity [ 16 – 21 ]. In this study, we aimed to explore the protective effects of bone marrow MSCs (BMMSCs) combined with NMP on DCD donor livers, from a new perspective on ferroptosis of hepatocytes, in order to provide new basic medical evidence for this type of preservation scheme for DCD donor livers.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

et al. 2021

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Background To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. Material/Methods Twenty-four male rat DCD donor livers were randomly and averagely divided into normal, static cold storage (SCS), NMP, and NMP combined with BMMSCs groups. Liver function, bile secretion, and pathological features of DCD donor livers were detected to evaluate the protective effects of NMP and BMMSCs on DCD donor livers. Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. Results Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe 2+ levels. BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. Conclusions BMMSCs combined with NMP could reduce the level of ROS and free Fe 2+ in oxidative stress damaged rat DCD donor livers, potentially reduce the ferroptosis in hepatocytes, and repair both morphology and function of DCD donor livers.

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“…Genetic inhibition of CISD1 increased iron-mediated intramitochondrial lipid peroxidation, which contributes to erastin-induced ferroptosis [ 28 ]. Previous studies have shown that CISD1 was related to survival of glioma [ 30 ], and high CISD1 expression is a marker of better outcome in glioma [ 31 ]. Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport.…”

Section: Discussionmentioning

confidence: 99%

Expression and Prognostic Characteristics of Ferroptosis-Related Genes in Colon Cancer

Zhu

Xie

2021

IJMS

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Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. Previous studies have showed that ferroptosis plays an important regulatory role in the occurrence and development of tumors. Colon cancer is one of the major morbidities and causes of mortality in the world. This study used RNA-seq and colon cancer clinical data to explore the relationship between ferroptosis-related genes and colon cancer. Based on the fifteen prognostic ferroptosis-related genes, two molecular subgroups of colon cancer were identified. Surprisingly, we also found cluster2 was characterized by lower mutation burden and expression of checkpoint genes, better survival, and higher expression of NOX1. Moreover, cluster2 has fewer BRAF mutations. We also found the expression of NOX1 is related to the status of BRAF. Finally, using 15 ferroptosis-related genes from The Cancer Genome Atlas cohort, we constructed a prognosis model, and this model may be used to predict the prognosis of patients in clinics.

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Ferroptosis in Low-Grade Glioma: A New Marker for Diagnosis and Prognosis

Cited by 29 publications

References 28 publications

Ferroptosis‐related gene signature predicts prognosis and immunotherapy in glioma

Ferroptosis‐related gene signature predicts prognosis and immunotherapy in glioma

Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

Expression and Prognostic Characteristics of Ferroptosis-Related Genes in Colon Cancer

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