Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation

Abstract

Sun overexposure leads to higher risk of photoaging and skin cancer. The contribution of infrared (IR) and visible light (VIS) radiation is currently being taken into account in their pathogenesis. Erythema, hyperpigmentation, genotoxicity or the increase of matrix metalloproteinases (MMPs) expression are some of the effects induced by these types of radiation. Extracts of various botanicals endowed with antioxidant activity are emerging as new photoprotective compounds. A natural extract from Polypodium leucotomos (Fernblock®, FB) has antioxidant and photoprotective properties and exhibits a strong anti-aging effect. In this study, we evaluated the protective capacity of FB against the detrimental effects of infrared A (IRA) and VIS radiation in human dermal fibroblasts. We analyzed the effects of FB on the morphology, viability, cell cycle and expression of extracellular matrix components of fibroblasts subjected to VIS and IRA. Our results indicate that FB prevents cell damage caused by VIS and IRA. Moreover, it reduces the increase in MMP-1 and cathepsin K expression induced by both VIS and IRA radiation, and curbs alterations in fibrillin 1, fibrillin 2 and elastin expression. All these findings support FB as a feasible approach to prevent or treat skin damage caused by IRA or VIS exposure.

Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress

“…Statistical significance was determined using a t-test and analysis of variance (ANOVA), and p < 0:05 was considered statistically significant. [15][16][17][18][19]. Thus, we first corroborated that Fern-block® treatment had no toxic effect against cell viability (Figure 1(a)), as well as its protective effect attenuating UVB-induced decrease in cell proliferation/viability, as assessed by normalized cell count (Figure 1(b)).…”

“…The use of decoctions of this fern was widespread in traditional medicine amongst local indigenous populations in Central America against numerous ailments, and modern medicine has confirmed its notable potential as an active conferring skinspecific antioxidant activity and protection against sun radiation damage (including aging, hyperpigmentation, and DNA damage) [15]. However, while evidence supporting a boosting of endogenous antioxidant and xenobiotic stress systems in cells is highly relevant for the therapeutic potential of Fernblock® [16][17][18], our understanding of the molecular mechanisms by which this occurs is limited.…”

Protective Effect of the Aqueous Extract of Deschampsia antarctica (EDAFENCE®) on Skin Cells against Blue Light Emitted from Digital Devices

“…The VIS spectrum represents approximately 50% of the solar spectrum arriving on the earth's surface, but it was considered to have little impact on skin due to its low energy [4] and hence received little attention. However, recent observations of skin photodamage following VIS exposure and prevention strategies have sparked increased interest [5,6].…”

Sunscreen Boosting Effect by Solid Lipid Nanoparticles-Loaded Fucoxanthin Formulation

“…Cosmetics 2020, 7, 14 2 of 8 successful drug delivery agent for several reasons: (1) SLN has a high drug loading capacity and can increase the possibility of drug targeting so that we have better control over release kinetics. (2) toxicity is so acute and chronic SLN has outstanding physical and chemical storage stability [7][8][9]. NLC is also used for the storage of bioactive compounds due to possessing a high loading capacity and a lower water content of the particle suspension [10].…”

“…Oxidative stress is the primary cause of extrinsic aging or photoaging, caused mainly by UV radiation. The principal effects of UV radiation in the skin are DNA damage, oxidative stress, deleterious impact on the extracellular matrix, inflammation, and immunosuppression [2]. Therefore, to prevent UV-induced damage, the treatment of the skin with products containing functional antioxidant ingredients may be one of the useful strategies.…”