Protective Effect of the Aqueous Extract of Deschampsia antarctica (EDAFENCE®) on Skin Cells against Blue Light Emitted from Digital Devices

Lorrio, Silvia; Rodríguez-Luna, Azahara; Delgado-Wicke, Pablo; Mascaraque, Marta; Gallego, María Jesús Vivancos; Pérez-Davó, Azahara; González, Salvador; Juarranz, Ángeles

doi:10.3390/ijms21030988

Cited by 25 publications

(22 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All primer sequences used in this study were as follows: IL-6 forward: 5 -ATG AAC TCC TTC ACA AGC-3 , reverse: 5 -GTT TTC TGC CAG TGC CTC TTT G-3 (Bio Basic Canada Inc., Ontario, Canada). IL-8 forward, 5 -CTC TGT GTG AAG GTG CAG TTT TG-3 , reverse, 5 -TCT CTT CCA TCA GAA AGC TTT ACA ATA-3 ; COL1A1 forward, 5 -TGA GCC AGC AGA TCG AGA-3 reverse, 5 -ACC AGT CTC CAT GTT GCA GA-3 ; MMP1 forward, 5 -TCT GAC GTT GAT CCC AGA GAG CAG-3 reverse, 5 -CAG GGT GAC ACC AGT GAC TGC AC-3 and GAPDH forward, 5 -TCA ACA GCG ACA CCC AC-3 reverse, 5 -TCA ACA GCG ACA CCC AC-3 (Humanizing Genomics Macrogen, Geumcheon-gu, Seoul, South Korea) [56][57][58].…”

Section: Expression Of Il-6 Il-8 Col1a1 and Mmp1 Genes By Rt-qpcr Ana...mentioning

confidence: 99%

Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway

Mapoung

Umsumarng

Semmarath

et al. 2021

Plants

View full text Add to dashboard Cite

Ultraviolet-B (UVB) irradiation causes skin damage via deleterious effects including oxidative stress, inflammation, and collagen degradation. The photoprotective effects of a hyperoside-enriched fraction obtained from Houttuynia cordata Thunb. (H. cordata) on the attenuation of UVB-induced skin aging in human fibroblasts were investigated. The solvent-partition technique was used to establish the hyperoside-enriched fraction of H. cordata (HcEA). The active compounds identified in the H. cordata extracts were hyperoside, quercitrin, chlorogenic acid, and rutin. With regard to the photoprotective effects of H. cordata on UVB-irradiated dermal fibroblasts, HcEA and hyperoside inhibited intracellular ROS production and inflammatory cytokine secretions (IL-6 and IL-8), while increasing collagen type I synthesis along with downregulating MMP-1 gene and protein expressions. Mechanistically, the hyperoside-enriched fraction obtained from H. cordata inhibited UVB-irradiated skin aging through regulation of the MAPK signaling pathway by attenuating the activation of JNK/ERK/c-Jun in human dermal fibroblasts. The hyperoside-enriched fraction of H. cordata exerted potent anti-skin aging properties against UVB exposure. The findings of this study can be applied in the cosmetics industry, as H. cordata extract can potentially be used in pharmaceutical or cosmetic formulations as a photoprotective or anti-skin aging agent.

show abstract

Section: Expression Of Il-6 Il-8 Col1a1 and Mmp1 Genes By Rt-qpcr Ana...mentioning

confidence: 99%

Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway

Mapoung

Umsumarng

Semmarath

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…The spontaneously immortalized human cell line HaCaT exhibits normal morphogenesis and expresses all the major surface markers and functional activities of isolated keratinocytes; for this reason, HaCaT will be chosen as a model for the study of keratinocytes functions and for investigating the effects of the compounds of interest on an epidermal model. Lorrio et al demonstrated that a natural aqueous extract of Deschampsia antarctica protects skin against artificial ad natural light by reducing the production of ROS and hyperpigmentation in fibroblasts and melanocytes [11]. In this study, the chemical composition of the natural aqueous extract of Deschampsia antarctica was not described, while in our work, we obtained a phytocomplex highly strandardized in polyphenol content using the cell culture technology.…”

Section: Discussionmentioning

confidence: 58%

“…Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices. This, together with recent observations reporting that blue light can exert cytotoxic effects associated with oxidative stress and promote hyperpigmentation, has sparked interest in blue light and its potential harmful effects on skin [11]. Several studies report that blue light contributes to skin aging and carcinogenesis, mostly during direct sunlight exposure, similar to UVA [12].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Cultured Melissa officinalis Cells as Effective Ingredient to Protect Skin against Oxidative Stress, Blue Light, and Infrared Irradiations Damages

et al. 2021

View full text Add to dashboard Cite

Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices, which can induce cell oxidative stress, causing signs of early photo aging. The Melissa officinalis phytocomplex is a new standardized cosmetic ingredient obtained by an in vitro plant cell culture with a high content of rosmarinic acid. In this study, we examine the activity of the Melissa officinalis phytocomplex to protect skin against blue light and infrared damages, evaluating the ROS (Radical Oxygen Species) level in keratinocyte cell line from human skin (HaCaT) and Nrf2 (Nuclear factor erythroid 2-related factor 2), elastin, and MMP1 (Matrix Metalloproteinase 1) immunostaining in living human skin explants ex vivo. This phytocomplex demonstrates antioxidant activity by reducing ROS production and thus the oxidant damage of the skin caused by UV and blue light exposure. In addition, it inhibits blue light-induced Nrf2 transcriptional activity, IR-induced elastin alteration, and IR-induced MMP-1 release. This Melissa officinalis phytocomplex is a new innovative active ingredient for cosmetic products that is able to protect skin against light and screen exposure damages and oxidative stress.

show abstract

“…As aforementioned, an increasingly studied agent challenging skin homeostasis in modern life is highenergy blue light, a radiation wavelength emitted by digital devices and therefore reaching our body for extensive periods of time. Recent studies [85] mimicking artificial blue light exposure on in vitro cell cultures revealed that these wavelengths reduce cell viability (an effect more pronounced in melanocytes than in dermal fibroblasts), promote hyperpigmentation and morphological alterations, and induce mitochondrial dysfunction and oxidative stress. Of note, addition of Edafence® counteracted these effects and reduced oxidative stress and ROS accumulation, mitochondrial homeostasis, and stress markers in fibroblasts, as well as melanization of keratinocytes [85] .…”

Section: Light Radiationsmentioning

confidence: 99%

“…Scale bar: 50 µm. Adapted from [81,84,85] . UVB: ultraviolet B radiation; VIS: visible light spectrum; wIRA: infrared spectrum…”

Section: Light Radiationsmentioning

confidence: 99%

Deschampsia antarctica extract (Edafence®) as a powerful skin protection tool against the aging exposome

Mataix¹,

Rodríguez-Luna²,

Gutiérrez-Pérez³

et al. 2020

Plast Aesthet Res

Self Cite

View full text Add to dashboard Cite

The impact of the interaction of all combined environmental agents to which an individual is exposed during his/her lifetime, as well as how his/her organism responds to these influences, defines health, aging, and disease. The systematic, integrative characterization of the different elements making up the “exposome” is thus necessary to identify and exploit the potential of compounds capable of conferring protection with minimal side effects. Extracts from the natural world, containing synergistic combinations of compounds with antioxidant and protective properties, have long been used in traditional medicine. Modern science has the opportunity to leverage these substances honed by evolution and use them safely and reliably, with a profound mechanistic knowledge and guaranteeing standardization and absence of toxicity. Here, we discuss our current knowledge regarding the potential of a soluble extract of the hair grass Deschampsia antarctica (as its standardized commercial preparation Edafence®) to counteract the skin exposome and its impact on skin aging and disease.

show abstract

Protective Effect of the Aqueous Extract of Deschampsia antarctica (EDAFENCE®) on Skin Cells against Blue Light Emitted from Digital Devices

Cited by 25 publications

References 35 publications

Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway

Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway

In Vitro Cultured Melissa officinalis Cells as Effective Ingredient to Protect Skin against Oxidative Stress, Blue Light, and Infrared Irradiations Damages

Deschampsia antarctica extract (Edafence®) as a powerful skin protection tool against the aging exposome

Contact Info

Product

Resources

About