Deschampsia antarctica extract (Edafence®) as a powerful skin protection tool against the aging exposome

Abstract

The impact of the interaction of all combined environmental agents to which an individual is exposed during his/her lifetime, as well as how his/her organism responds to these influences, defines health, aging, and disease. The systematic, integrative characterization of the different elements making up the “exposome” is thus necessary to identify and exploit the potential of compounds capable of conferring protection with minimal side effects. Extracts from the natural world, containing synergistic combinations of compounds with antioxidant and protective properties, have long been used in traditional medicine. Modern science has the opportunity to leverage these substances honed by evolution and use them safely and reliably, with a profound mechanistic knowledge and guaranteeing standardization and absence of toxicity. Here, we discuss our current knowledge regarding the potential of a soluble extract of the hair grass Deschampsia antarctica (as its standardized commercial preparation Edafence®) to counteract the skin exposome and its impact on skin aging and disease.

Aryl Hydrocarbon Receptor as a Therapeutical Target of Environmentally Induced Skin Conditions

“…Together, these results suggest the potential of the extract in skin protection against environmental stressors, both for its antioxidant activity and AhR modulation ability (Mataix et al, 2020).…”

“…This is partly due to photostabilizing compounds, dehydrins, and phenolics, such as luteolin and apigenin. (Mataix et al, 2020). The protective effect of the commercial extract (Edafence ® Cantabria Labs, Madrid, Spain) was investigated on keratinocytes and fibroblasts exposed to UVA, UVB, and TCDD.…”

The deleterious effects induced by an acute exposure of human skin to common air pollutants are prevented by extracts of Deschampsia antarctica

“…Working concentrations for toxic compounds were previously established in human skin primary cells, fibroblasts and keratinocytes as described 76 , 77 . For the preparation of working solutions of the different toxic compunds, 9 mM of NaAsO 2 (As(III), arsenic), 0,3 mM of CdCl 2 (Cd(II), Cadmium), 0.5 mM of CrO 3 and CrCl 3 , at equal concentrations, (Cr(III/VI), Chromium), 10 nM of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or dilutions of Tobacco Smoke (TS) extract infusions, were dissolved in supplemented DMEM culture medium and filtered through a 0.2 µm pore membranes.…”

B1 repetitive sequence methylation enhances wound healing of second‑degree burns in rats

“…Burns and heat stress can cause DNA damage in various cells and animals (11,(25)(26)(27)(28)(29)(30) and result in DNA damage responses (31). For example, in heated germline cells, an increase in 8-hydroxy-2'-deoxyguanosine (8-OHdG) level was observed in response to DNA damage (32).…”