Sunscreen Boosting Effect by Solid Lipid Nanoparticles-Loaded Fucoxanthin Formulation

Abstract

Fucoxanthin is a bioactive compound that is a kind of natural carotenoid. Fucoxanthin is known to protect against UV-B-induced cell damage in hairless mice, even though it is physiochemically unstable to heat and acid due to its polyunsaturated structure, indicating that fucoxanthin possesses a low bioavailability, and this disadvantage limits its application in the cosmetic industry. Solid lipid nanoparticle (SLN) systems are known to be suitable as carriers for sunscreen agents. In this research work, the sunscreen-boosting effect of SLN, as a deliverer of functional ingredient, especially fucoxanthin, has been developed and evaluated by comparing the sunburn protection factors (SPF) of macroemulsion (cream and lotion type) and an SLN formula containing various kinds of sunscreen agents, respectively. Several results such as stability test, particle size, DSC analysis, and X-ray analysis show that the SLN formula loading fucoxanthin has the possibility of being a stable and high-functioning ingredient delivery system. Moreover, the SLN formula has shown a higher SPF value than others, meaning that the SLN formula exhibits a good sunscreen-boosting effect. This study indicates that the use of SLN as a carrier enhanced the bioavailability of fucoxanthin and shows that SLN could be a promising carrier for the production of sunscreen products by allowing the scaling-up of production.

The Critical Studies of Fucoxanthin Research Trends from 1928 to June 2021: A Bibliometric Review

“…For instance, a topical formulation containing fucoxanthin has been developed that could prevent exacerbations related to skin inflammatory pathologies and protect skin against UV radiation [159]. In addition, solid lipid nanoparticle formulation loaded with fucoxanthin demonstrated the UV-blocking potential [160]. Furthermore, Kang et al (2020) reported that fucoxanthin concentrate extracted from P. tricornutum could be utilized as an active ingredient in wrinkle care cosmetics [161].…”

Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements

“…They show improved biocompatibility and safety and act as a successful transporter delivery system in cosmeceutical applications [ 12 ]. Since 2005, SLNs have been used in several dermal cosmetic products to achieve good outcomes [ 83 , 84 ]. SLNs are widely used in formulating sunscreens, where they act as active carriers for molecular sunscreen agents.…”

“…A recent experimental study carried out on an SLN formulation integrating fucoxanthin (protects against UVB light) concluded that the presence of the SLN carrier improved the bioavailability of fucoxanthin and can be a promising carrier for sunscreen cosmetics, showing greater stability and good sunscreen-boosting action [ 84 , 87 ]. Another study combined the capability of the flavonoid as a natural antioxidant with NLCs to form an effective system for delivery into the cells.…”

Scientific Approaches on Extraction, Purification and Stability for the Commercialization of Fucoxanthin Recovered from Brown Algae

“…These results seem to indicate that the oral or topical administration of fucoxanthin can prevent or even reduce the negative effects induced by UV radiation exposure, such as the appearance of melanomas. In fact, due to its antioxidant capacity, fucoxanthin has been tested in several anti-aging and anti-sun cosmetic formulations [101,102]. In the cosmetics and pharmaceutical industries, this carotenoid is also relevant, due to its skin protective effects against burns and filaggrin (filament aggregating protein) disorder induced by radiation.…”

“…These results seem to indicate that the oral or topical administration of fucoxanthin can prevent or even reduce the negative effects induced by UV radiation exposure, such as the appearance of melanomas. In fact, due to its antioxidant capacity, fucoxanthin has been tested in several anti-aging and anti-sun cosmetic formulations [ 101 , 102 ].…”