Fenugreek seed extract and its phytocompounds- trigonelline and diosgenin arbitrate their hepatoprotective effects through attenuation of endoplasmic reticulum stress and oxidative stress in type 2 diabetic rats

Mayakrishnan, Tharaheswari; Nakkala, Jayachandra Reddy; Jeepipalli, Syam Praveen Kumar; Raja, Kumar; Chandra, Vikash; Mohan, V.; Rani, Sapna

doi:10.1007/s00217-014-2322-9

Cited by 22 publications

(10 citation statements)

References 34 publications

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“…Diosgenin protects pancreatic islet β‐cells and upregulates hepatic glucose kinase (Fuller & Stephen, 2015). Trigonelline improves insulin signaling pathway (Aldakinah, Al‐Shorbagy, Abdallah, & El‐Abhar, 2017), attenuates the endoplasmic reticulum stress and oxidative stress in type 2 diabetic rats (Mayakrishnan et al., 2015), and affects the regeneration of pancreatic islet β‐cells, the secretion of insulin, and glucose metabolizing enzymes (Zhou, Chan, & Zhou, 2012). Flavone C ‐glycosides can inhibit digestive enzymes, activate insulin signaling, and reduce the formation of advanced glycation end products (Xiao, Capanoglu, Jassbi, & Miron, 2016).…”

Section: Natural Products Based Antidiabetic Drug Discoverymentioning

confidence: 99%

Dietary polyphenols as antidiabetic agents: Advances and opportunities

et al. 2020

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Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on "polyphenols and diabetes" significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents.Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulindependent approaches, for instance, protection of pancreatic islet -cell, reduction of -cell apoptosis, promotion of -cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as the This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. c ○ 2020 The Authors. Food Frontiers published

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Section: Natural Products Based Antidiabetic Drug Discoverymentioning

confidence: 99%

Dietary polyphenols as antidiabetic agents: Advances and opportunities

et al. 2020

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“…Interestingly, it was evidenced that fenugreek seed extracts have hepatoprotective effects which could be associated with diosgenin acting through attenuation of endoplasmic reticulum stress and oxidative stress in type 2 diabetic rats [69]. …”

Section: Pharmacology: Recent Datamentioning

confidence: 99%

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Jesus

Martins

Gallardo

et al. 2016

Journal of Analytical Methods in Chemistry

197

125

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Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. However, other alternative methods were also published. Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well.

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“…Additionally, TSCF dose-dependently recovered SOD levels of the T2DM mice. It has been reported that hepatic inflammation and oxidative stress are closely connected with diabetes [ 32 ]. Thus, all these data suggested that TSCF potently attenuated inflammation and oxidative stress in T2DM mice.…”

Section: Resultsmentioning

confidence: 99%

Total Saponins Isolated from Corni Fructus via Ultrasonic Microwave-Assisted Extraction Attenuate Diabetes in Mice

Niu

Wang

et al. 2021

Foods

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Saponins have been extensively used in the food and pharmaceutical industries because of their potent bioactive and pharmacological functions including hypolipidemic, anti-inflammatory, expectorant, antiulcer and androgenic properties. A lot of saponins-containing foods are recommended as nutritional supplements for diabetic patients. As a medicine and food homologous material, Corni Fructus (CF) contains various active ingredients and has the effect of treating diabetes. However, whether and how CF saponins attenuate diabetes is still largely unknown. Here, we isolated total saponins from CF (TSCF) using ultrasonic microwave-assisted extraction combined with response surface methodology. The extract was further purified by a nonpolar copolymer styrene type macroporous resin (HPD-300), with the yield of TSCF elevated to 13.96 mg/g compared to 10.87 mg/g obtained via unassisted extraction. When used to treat high-fat diet and streptozotocin-induced diabetic mice, TSCF significantly improved the glucose and lipid metabolisms of T2DM mice. Additionally, TSCF clearly ameliorated inflammation and oxidative stress as well as pancreas and liver damages in the diabetic mice. Mechanistically, TSCF potently regulated insulin receptor (INSR)-, glucose transporter 4 (GLUT4)-, phosphatidylinositol 3-kinase (PI3K)-, and protein kinase B (PKB/AKT)-associated signaling pathways. Thus, our data collectively demonstrated that TSCF could be a promising functional food ingredient for diabetes improvement.

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Fenugreek seed extract and its phytocompounds- trigonelline and diosgenin arbitrate their hepatoprotective effects through attenuation of endoplasmic reticulum stress and oxidative stress in type 2 diabetic rats

Cited by 22 publications

References 34 publications

Dietary polyphenols as antidiabetic agents: Advances and opportunities

Dietary polyphenols as antidiabetic agents: Advances and opportunities

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Total Saponins Isolated from Corni Fructus via Ultrasonic Microwave-Assisted Extraction Attenuate Diabetes in Mice

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