Fenilpropanóides e outros constituintes bioativos de Nectandra megapotamica

Garcez, Fernanda Rodrigues; Garcez, Walmir Silva; Hamerski, Lidilhone; Miguita, Carlos Henrique

doi:10.1590/s0100-40422009000200026

Cited by 37 publications

(35 citation statements)

References 8 publications

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“…The occurrence of phenylpropanoids in N. megapotamica was reported previously, 14 in which elemicin and isoelemicin were detected from stem bark. However, in the present work, only a reduced relative amount (1.3-1.6%) of one C 6 C 3 derivative, safrole, was found in the volatile oil from leaves in February, being lower in August samples (0.4%).…”

Section: Resultssupporting

confidence: 67%

“…12,13 Furthermore, recent chemical studies reported the isolation of four phenylpropanoids, one gallic acid derivative, one flavan and one sesquiterpene. 14 The antitumoral, anti-inflammatory and antimicrobial activities of the volatile oil obtained from N. megapotamica also had been previously evaluated, but, the compounds presented in these samples were not reported. 15 Thus, in continuation of our studies about volatile oils from São Paulo city species, 16 in this work we report, at first time, the chemical composition of the volatile oils from N. megapotamica leaves collected in two distinct months at different hours of a day.…”

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confidence: 99%

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Chemical composition of volatile oils from leaves of Nectandra megapotamica Spreng. (Lauraceae)

Romoff¹,

Ferreira²,

Padilla³

et al. 2010

Quím. Nova

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Recebido em 2/9/09; aceito em 14/1/10; publicado na web em 23/4/10The volatile oils from Nectandra megapotamica Spreng. leaves, collected in February and August of 2007 and at 7:00 and 12:00 h (samples A -D), were extracted by hydrodistillation and the chemical composition was analyzed by GC-FID and GC/MS. A total of nineteen compounds were identified with predominance of oxygenated sesquiterpenes, among them, a-bisabolol, was the main constituent (62.3-69.4 %). After chromatographic separation procedures, this compound was purified from crude oil and its structure was confirmed by analysis of NMR data. This paper describes for the first time the composition of the leaves volatile oil from N. megapotamica.

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Section: Resultssupporting

confidence: 67%

mentioning

confidence: 99%

Chemical composition of volatile oils from leaves of Nectandra megapotamica Spreng. (Lauraceae)

Romoff¹,

Ferreira²,

Padilla³

et al. 2010

Quím. Nova

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“…Previous pharmacological investigation using mice and rats have showed analgesic and anti-inflammatory activities for the bark hydroalcoholic extract of this species (da Silva et al, 2004). Additionally, studies have showed that the ethanolic extract from the trunk bark presents antioxidant and antimicrobial activities (Garcez et al, 2009), while for the leaf essential oil, literature describes anti-inflammatory and antitumor activities (Apel et al, 2006). Snooks (Centropomus spp.)…”

Section: Introductionmentioning

confidence: 99%

Anesthesia and transport of fat snook Centropomus parallelus with the essential oil of Nectandra megapotamica(Spreng.) Mez

et al. 2013

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This study analyzed the chemical composition and anesthetic potential of essential oil (EO) of Nectandra megapotamica in fat snook (Centropomus parallelus). For the extraction of EO by hydrodistillation, leaves were separated in young (EO-Y) or old (EO-O), and the chemical composition of the EOs was determined by CG-MS. The anesthetic potential was assessed by the evaluation of induction and recovery time of anesthesia and stress response from anesthesia and transport. Three experiments were carried out: i) four different concentrations of each EO were tested to evaluate anesthesia induction and recovery time; ii) two concentrations of EO-O were tested for the evaluation of its effects on stress parameters (glucose, lactate, and Na + and K + plasma levels) caused by anesthesia; and iii) fish were transported in plastic bags, supplied with two concentrations of EO-O for the evaluation of water quality and mortality. All experiments were performed on fish acclimated to 0 and 33 ppt salinity. The main constituents of the Y and O-EOs were bicyclogermacrene (46.5/34.6%), α-pinene (26.8/26.2%), β-pinene (7.9/12.3%), and germacrene D (9.6/9.1%). Mild sedation was achieved at 30 µL L -1 (1.3-3.2 min) and deep anesthesia at 150 µL L -1 (5.6-8.0 min) with both EOs. The recovery time ranged from 1-10 min. The EO-O was not able to avoid the stress of anesthesia evidenced by elevated glucose and lactate plasma levels observed in all groups. Plasma levels of Na + and K + were not significantly affected by treatments. During transport, the use of EO-O did not prevent deterioration in water quality and the post-transport mortality. In conclusion, the EO of N. megapotamica has anesthetic activity in fat snook, but it was not able to prevent the stress of anesthesia and transport.Este estudo analisou a composição química e o potencial anestésico do óleo essencial (OE) de Nectandra megapotamica em robalos-peva (Centropomus parallelus). Para a extração do OE por hidrodestilação, as folhas foram separadas em jovens (OE-J) ou velhas (OE-V) e a composição química foi determinada por CG-EM. O potencial anestésico foi acessado através da avaliação do tempo de indução e recuperação da anestesia e resposta ao estresse do procedimento anestésico e transporte. Foram realizados três experimentos: em primeiro lugar, quatro concentrações diferentes de cada OE foram testadas para avaliar o tempo de indução à anestesia e de recuperação; em segundo lugar, duas concentrações do OE-V foram testadas para avaliar os efeitos sobre os parâmetros de estresse (níveis plasmáticos de glicose, lactato, Na + e K + ) causados pelo procedimento anestésico; em terceiro lugar, os peixes foram transportados em sacos plásticos com duas concentrações do OE-V para avaliação da qualidade da água e mortalidade. Todos os experimentos foram realizados em peixes aclimatados à salinidade zero e 33. Os constituintes majoritários do OE-J e OE-V foram: biciclogermacreno (46,5/34,6%), α-pineno (26,8/26,2%), β-pineno (7,9/12,3%) e germacreno D (9,6/9,1%). Sedação leve foi alca...

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“…4 Its popular use as a disinfectant for wounds and respiratory diseases has not been documented in the literature, being obtained by popular information. Previous phytochemical studies of the extract of the trunk of this species revealed the presence of sesquiterpenes and phenylpropanoids, 15 alkaloids 8 as well as lignans with leishmanicidal, trypanocidal, 16 analgesic and anti-inflammatory activities. 9,17 From the leaves, neolignans with in vitro trypanocidal activity were obtained.…”

Section: Introductionmentioning

confidence: 90%

“…9,17 From the leaves, neolignans with in vitro trypanocidal activity were obtained. 15 Studies with the essential oil content of this species collected in the state of São Paulo showed that the essential oil has anti-inflammatory, antitumor and antimicrobial activity against E. aureus. 17 As in previous studies, 17,18 most of them carried out in the state of São Paulo, different individuals of the same species and region have shown variability in their chemical constitution.…”

Section: Introductionmentioning

confidence: 99%

Sesquiterpenoids fromNectandra megapotamica(Lauraceae)

Oliveira¹,

Morandini²,

Pedroso³

et al. 2016

Journal of the Brazilian Chemical Society

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Five sesquiterpenoid oxides, named nectandrene A, B, C, D, and E, were isolated from the essential oil of the leaves of Nectandra megapotamica. Their structures were elucidated by spectroscopic analysis, and the relative configurations were proposed by their nuclear Overhauser effect (NOESY) spectrum. Three of these isolated compounds displayed significant antimicrobial activity; the compound most active had minimal inhibitory concentration (MIC) values between 3.12 and 25.0 μg mL -1 against some tested bacteria, and antifungal activity with MIC values between 12.5 and 25.0 μg mL -1 .

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Fenilpropanóides e outros constituintes bioativos de Nectandra megapotamica

Cited by 37 publications

References 8 publications

Chemical composition of volatile oils from leaves of Nectandra megapotamica Spreng. (Lauraceae)

Chemical composition of volatile oils from leaves of Nectandra megapotamica Spreng. (Lauraceae)

Anesthesia and transport of fat snook Centropomus parallelus with the essential oil of Nectandra megapotamica(Spreng.) Mez

Sesquiterpenoids fromNectandra megapotamica(Lauraceae)

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