Femtosecond laser micro-nano structured Ag SERS substrates with unique sensitivity, uniformity and stability for food safety evaluation

Luo, Xianwu; Liu, Weijian; Chen, Changhao; Jiang, Guochen; Hu, Xinyu; Zhang, Hongjun; Zhong, Minlin

doi:10.1016/j.optlastec.2021.106969

Cited by 50 publications

(13 citation statements)

References 51 publications

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“…In contrast, femtosecond (fs) laser ablation offers a scalable, tunable, single step, and reproducible approach to SERS substrate fabrication. [34][35][36][37][38] Many efforts have been focused on exploiting fs-laser machining to tune surface wettability, creating combinations of superhydrophobic/philic areas that enhance detection performance by concentrating analyte molecules into hotspot areas, leading to the detection of concentrations down to 10 −13 M using SERS. [39][40][41][42] Additionally, fs-laser induced plasma assisted ablation has been used to create active SERS substrates based on Ag nanoparticles, demonstrating promising results regarding food safety detection.…”

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confidence: 99%

Classification of Preeclamptic Placental Extracellular Vesicles Using Femtosecond Laser-fabricated Nanoplasmonic Sensors and Machine Learning

Kazemzadeh

Martínez-Calderón

Paek

et al. 2021

Preprint

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Placental extracellular vesicles (EVs) play an essential role in pregnancy by protecting and transporting diverse biomolecules that aid in fetomaternal communication. However, in preeclampsia, they have also been implicated in contributing to disease progression. Despite their potential clinical value, most current technologies cannot provide a rapid and effective means of differentiating between healthy and diseased placental EVs. To address this, we developed a fabrication process called laser-induced nanostructuring of SERS-active thin films (LINST), which produces nanoplasmonic substrates that provide exceptional Raman signal enhancement and allow the biochemical fingerprinting of EVs. After validating LINST performance with chemical standards, we used placental EVs from tissue explant cultures and demonstrated that preeclamptic and normotensive placental EVs have classifiably distinct Raman spectra following the application of both conventional and advanced machine learning algorithms. Given the abundance of placental EVs in maternal circulation, these findings will encourage immediate exploration of surface-enhanced Raman spectroscopy (SERS) as a promising method for preeclampsia liquid biopsies, while our novel fabrication process can provide a versatile and scalable substrate for many other SERS applications.

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confidence: 99%

Classification of Preeclamptic Placental Extracellular Vesicles Using Femtosecond Laser-fabricated Nanoplasmonic Sensors and Machine Learning

Kazemzadeh

Martínez-Calderón

Paek

et al. 2021

Preprint

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“… 39 Such a low limit of detection enables the as-fabricated silicon nanograss arrays SERS substrates could be utilized toward the goal of trace analysis of illegal additive residues. 40 The increasing trend of SERS intensity with Sudan I concentration is further summarized in Fig. 8b for quantitative Sudan I sensing.…”

Section: Resultsmentioning

confidence: 84%

AgNPs decorated 3D bionic silicon nanograss arrays pattern with high-density hot-spots for SERS sensing via green galvanic displacement without additives

Wang

Huang

et al. 2021

RSC Adv.

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“…All of this makes it a versatile process to be exploited in the creation of antimicrobial surfaces, representing a convenient alternative to other methodologies that require several steps for sample preparation and the use of complex apparatuses which often involve limitations in terms of the material, size and shape of the sample to be processed. Furthermore, the USL processing to produce rough surfaces capable of exploiting the SERS effect due to the presence of plasmonic materials has aroused growing interest in recent years [70,71]. This opens the possibility, for our process, to find an application in the realization of SERS-based biosensors.…”

Section: Resultsmentioning

confidence: 99%

Single-Step Process for Titanium Surface Micro- and Nano-Structuring and In Situ Silver Nanoparticles Formation by Ultra-Short Laser Patterning

et al. 2022

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Ultra-short laser (USL)-induced surface structuring combined with nanoparticles synthesis by multiphoton photoreduction represents a novel single-step approach for commercially pure titanium (cp-Ti) surface enhancement. Such a combination leads to the formation of distinct topographical features covered by nanoparticles. The USL processing of cp-Ti in an aqueous solution of silver nitrate (AgNO3) induces the formation of micron-sized spikes surmounted by silver nanoparticles (AgNPs). The proposed approach combines the structuring and oxidation of the Ti surface and the synthesis of AgNPs in a one-step process, without the use of additional chemicals or a complex apparatus. Such a process is easy to implement, versatile and sustainable compared to alternative methodologies capable of obtaining comparable results. Antimicrobial surfaces on medical devices (e.g., surgical tools or implants), for which titanium is widely used, can be realized due to the simultaneous presence of AgNPs and micro/nano-structured surface topography. The processed surfaces were examined by means of a scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM) and Raman spectroscopy. The surface morphology and the oxidation, quality and quantity of AgNPs were analyzed in relation to process parameters (laser scanning speed and AgNO3 concentration), as well as the effect of AgNPs on the Raman signal of Titanium oxide.

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Femtosecond laser micro-nano structured Ag SERS substrates with unique sensitivity, uniformity and stability for food safety evaluation

Cited by 50 publications

References 51 publications

Classification of Preeclamptic Placental Extracellular Vesicles Using Femtosecond Laser-fabricated Nanoplasmonic Sensors and Machine Learning

Classification of Preeclamptic Placental Extracellular Vesicles Using Femtosecond Laser-fabricated Nanoplasmonic Sensors and Machine Learning

AgNPs decorated 3D bionic silicon nanograss arrays pattern with high-density hot-spots for SERS sensing via green galvanic displacement without additives

Single-Step Process for Titanium Surface Micro- and Nano-Structuring and In Situ Silver Nanoparticles Formation by Ultra-Short Laser Patterning

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