Femtosecond Laser-Based Integration of Nano-Membranes into Organ-on-a-Chip Systems

Bakhchova, Liubov; Jonušauskas, Linas; Andrijec, Dovilė; Kurachkina, Marharyta; Baravykas, Tomas; Eremin, Alexey; Steinmann, Ulrike

doi:10.3390/ma13143076

Cited by 11 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thereby, FS micromachining technology is adopted to solve this problem. The information provided in the literature is analyzed [ 25 ]. The optical power splitter is prepared by FS technology, and the physical properties of the photoresist are analyzed.…”

Section: Methodsmentioning

confidence: 99%

The use of remote Femto Second technology in the preparation of black silicon material and optical devices

Chen²

2023

PLoS ONE

View full text Add to dashboard Cite

The research aims to study the application of remote Femto Second (FS) technology in black silicon material preparation and optical devices. Based on the principle and characteristic research of FS technology, the interaction between FS and silicon is adopted to propose a scheme for preparing black silicon material through experiments. Moreover, the experimental parameters are optimized. Then, the scheme of using the FS for etching polymer optical power splitter as a new technical means is proposed. In addition, while ensuring processing accuracy, the appropriate process parameters of laser etching photoresist are obtained. The results show that the performance of black silicon prepared with SF6 as the background gas is greatly improved in the 400-2200nm range. However, the performance of black silicon samples with the two-layer structure etched at different laser energy densities has little difference. Black silicon with a Se+Si two-layer film structure has the best optical absorption performance in the infrared range of 1100nm-2200nm. Besides, the optical absorption rate is the highest when the laser scanning rate is 0.5mm/s. In the band of >1100nm, when the maximum laser energy density is 6.5kJ/m2, the overall absorption of the etched sample is the worst. The absorption rate is the best when the laser energy density is 3.9kJ/m2. It suggests that the proper parameter selection greatly impacts the quality of the final laser-etched sample.

show abstract

Section: Methodsmentioning

confidence: 99%

The use of remote Femto Second technology in the preparation of black silicon material and optical devices

Chen²

2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Nevertheless, a wide range of materials allows finding the optimal one for the chosen application. Using this method, it is possible to structure the 3D objects even inside of the fabricated microfluidic channel [ 95 ]. A schematic view of the 3DLL technology is shown in Figure 2 .…”

Section: Methods For Manufacturing Microfluidic Structures For Biosen...mentioning

confidence: 99%

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

et al. 2022

Self Cite

View full text Add to dashboard Cite

Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of biosensors with minimal requirements for sample preparation by omitting expensive labelling reagents. The aim of the present work is to review the variety of physical label-free techniques of protein detection and characterization which are suitable for application in micro-fluidic structures and analyze the technological and material aspects of label-free biosensors that implement these methods. The most widely used optical and impedance spectroscopy techniques: absorption, fluorescence, surface plasmon resonance, Raman scattering, and interferometry, as well as new trends in photonics are reviewed. The challenges of materials selection, surfaces tailoring in microfluidic structures, and enhancement of the sensitivity and miniaturization of biosensor systems are discussed. The review provides an overview for current advances and future trends in microfluidics integrated technologies for label-free protein biomarkers detection and discusses existing challenges and a way towards novel solutions.

show abstract

“…[202] Due to the high resolution of multiphoton lithography, it has become possible to create nanochannels approaching the sizes of ion channels in biological membranes. [204,205] Organ-on-a-chip platforms are provided with sensing systems based on various physical principles for analyzing the state of cellular structures and controlling the parameters of their environment. Inkjet printing is actively used to form electrodes designed to control the electrophysical and electrochemical parameters of cells and their microenvironment.…”

Section: D-printed Microfluidic Systems and Microenvironmental Contro...mentioning

confidence: 99%

“…[ 202 ] Due to the high resolution of multiphoton lithography, it has become possible to create nanochannels approaching the sizes of ion channels in biological membranes. [ 204,205 ]…”

Section: D Printing Of Microphysiological Biohybrid Systemsmentioning

confidence: 99%

3D Printed Biohybrid Microsystems

Prinz

Fritzler

2022

Adv Materials Technologies

View full text Add to dashboard Cite

are not able to fully meet the challenges related to the creation of such systems. A number of methods are known that make it possible to form 3D structures, for example, Rolling-Up technology and imprint lithography. [1][2][3][4] However, a rather short list of materials that can be used in such technologies and a too narrow range of 3D shapes that can be fabricated using these methods seriously limit the application fields of the techniques. It seems that additive manufacturing (AM) technology, or 3D printing, presents a much more universal and promising technological approach in this field. AM technology is the process of forming structures and devices by layer-by-layer (or pointby-point) application of materials in accordance with a 3D digital computer aided design (CAD) model. [5] The results of recent years convincingly show that the rapidly progressing AM technology, which uses the widest range of materials, including biological ones, has become the technological basis and the driving force of new breakthrough fields, including biology and medicine. [6,7] The purpose of our review is to analyze the role and achievements of 3D micro-and nanoprinting in the development of one of the most advanced fields, biohybrid systems (BHS), formed by the integration of at least one biological component with at least one artificial element. In the creation of such systems, the desire was manifested to combine the unique capabilities of living biosystems, having been perfected during the millions of years of evolution, with the functionality of artificially made structures. This integration leads to a synergistic effect and significantly expands the capabilities of the devices being created, which are in demand in various fields, primarily in biology and medicine. This review by no means aims to provide an exhaustive picture of the entire field of biohybrid materials and structures; instead, it is devoted to the consideration of smart biohybrid microsystems. These are complex multifunctional devices that allow recording the biophysical and biochemical parameters of biological objects and exerting active control on those parameters for treatment or research. [8][9][10][11][12][13] The functionality of such systems is provided by micro-and nanotools, for the production of which high-resolution additive methods are used. These are various optical, electronic, mechanical microand nanostructures that are used as activators, capsules for transporting cells or active substances, elements of microfluidic systems, sensors, microelectrode arrays, etc. The review addresses the formation and integration of such structures into smart biohybrid microsystems. The review outlines the most This review is devoted to the role of 3D printing in the development of a new high-tech field, smart biohybrid microsystems. The motivation behind the development of this field is the intention to integrate the capabilities of biological systems optimized in the course of evolution with the achievements of modern methods of forming micro-and nanostructu...

show abstract

Femtosecond Laser-Based Integration of Nano-Membranes into Organ-on-a-Chip Systems

Cited by 11 publications

References 43 publications

The use of remote Femto Second technology in the preparation of black silicon material and optical devices

The use of remote Femto Second technology in the preparation of black silicon material and optical devices

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

3D Printed Biohybrid Microsystems

Contact Info

Product

Resources

About